Q8U9V0 (AROB_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Atu3625
ORF Names:	AGR_L_2401

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. HAMAP MF_00110 Divalent metal cations By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140705

Sequences

	Sequence		Length	Mass (Da)
	Q8U9V0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 5B75B42CE204EA17	FASTA	377	40,050
	10 20 30 40 50 60 MTPSEIHADE RLVHVPLGER AYDILIGPGL IGRAGGEISA RLKGRRAAII TDEHVAPLYL 70 80 90 100 110 120 EGLMDGLQTD GIEAVSLTLP AGEKTKSFEH LVTVCDAVLS ARVERNDAVI ALGGGVIGDL 130 140 150 160 170 180 AGFAAGIVRR GVRFVQIPTS LLSQVDSSVG GKTGINTRHG KNLVGVFHQP DLVLADTAVL 190 200 210 220 230 240 DTLSPREFRA GYAEVVKYGL IDKPDFFFWL EKNWDDIRTG GPARIEAIAT SCQAKADVVV 250 260 270 280 290 300 ADEKENGVRA LLNLGHTFGH ALEAATNYDS KRLVHGEGVA IGMVLAHQFS ARLNLASPDD 310 320 330 340 350 360 AARVEAHLKA VGLPTTMKDI PGELPPVETL MAAIAQDKKV KGGKLTFILT HGIGQSFVAD 370 DVASSEVQSF LSEKHPG

References

[1]	"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
[2]	"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007870 Genomic DNA. Translation: AAK89771.1.
PIR	A99281. AG3002.
RefSeq	NP_356986.1. NC_003063.2.
3D structure databases
ProteinModelPortal	Q8U9V0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8U9V0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1135499.
GenomeReviews	Gene locus Atu3625 in contig AE007870_GR.
KEGG	atu:Atu3625.
PATRIC	20816722. VBIAgrTum91616_3472.
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	GTFTQPD.
PhylomeDB	Q8U9V0.
ProtClustDB	PRK00002.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU3625-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_AGRT5

Accession

Primary (citable) accession number: Q8U9V0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program