Reviewed, UniProtKB/Swiss-Prot Q8U7Y1 (XYLD_AGRT5)

Names and origin

Protein names

Recommended name:
    Putative D-xylulose reductase
    EC=1.1.1.9
Alternative name(s):
    Xylitol dehydrogenase
      Short name=XDH

Gene names

Ordered Locus Names:	Atu4318
ORF Names:	AGR_L_1091

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Xylitol + NAD+ = D-xylulose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylulose reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Putative D-xylulose reductase		PRO_0000160884
Sites
	Metal binding	43	1	Zinc; catalytic By similarity
	Metal binding	68	1	Zinc; catalytic By similarity
	Metal binding	154	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8U7Y1-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 9C6FB260277F137E	FASTA	350	36,776
	10 20 30 40 50 60 MKALVLEEKG KLSLRDFDIP GGAGSGELGP KDVRIRTHTV GICGSDVHYY THGKIGHFVV 70 80 90 100 110 120 NAPMVLGHEA SGTVIETGSD VTHLKIGDRV CMEPGIPDPT SRASKLGIYN VDPAVRFWAT 130 140 150 160 170 180 PPIHGCLTPE VIHPAAFTYK LPDNVSFAEG AMVEPFAIGM QAALRARIQP GDIAVVTGAG 190 200 210 220 230 240 PIGMMVALAA LAGGCAKVIV ADLAQPKLDI IAAYDGIETI NIRERNLAEA VSAATDGWGC 250 260 270 280 290 300 DIVFECSGAA PAILGMAKLA RPGGAIVLVG MPVDPVPVDI VGLQAKELRV ETVFRYANVY 310 320 330 340 350 DRAVALIASG KVDLKPLISA TIPFEDSIAG FDRAVEARET DVKLQIVMPQ

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE007870 Genomic DNA. Translation: AAK89121.1.
PIR	AB3087. G98199.
RefSeq	NP_356336.1.
3D structure databases
HSSP	HSSP built from PDB template 1E3J based on UniProtKB O96496.
ModBase	Search...
Genome annotation databases
GeneID	1136192.
GenomeReviews	Gene locus Atu4318 in contig AE007870_GR.
KEGG	atc:AGR_L_1091. atu:Atu4318.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8U7Y1.
OMA	Q8U7Y1. GMPVDPV.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLD_AGRT5

Accession

Primary (citable) accession number: Q8U7Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)