Q8U705 (ARLY2_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase 2
Short name=ASAL 2
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH2
Ordered Locus Names:	Atu4651
ORF Names:	AGR_L_463

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Sequence caution	The sequence AAK88796.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Argininosuccinate lyase 2 HAMAP MF_00006		PRO_0000137731

Sequences

	Sequence		Length	Mass (Da)
	Q8U705 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 2BBD2A090791CFB8	FASTA	504	55,699
	10 20 30 40 50 60 MADINPRQSD TSKFPDPVYK ETVLRPLFDG AKNHHVDGFR RIDRAHLVML RETGILDAET 70 80 90 100 110 120 AAKIAGALED IDRTIEPSEL VYTGEVEDFF FLIEKELKAR IGVDVAGRLH TARSRNDIDH 130 140 150 160 170 180 TLFKIGLKDK IDTLTAKARV LLKALIDAAE RNQSTLIVAY THGQPAQPTT FGHYLSAAIE 190 200 210 220 230 240 VLIRDIERFT EARHIVDLSP MGAAAITTSG FPIDRARVAE LLGFAAPLRN SYSCIAAVDY 250 260 270 280 290 300 TTATYGAIEL MFLHLGRLIQ DFQFWTSFEV GQIYVPNSLV QISSIMPQKR NPVPIEHLRH 310 320 330 340 350 360 LASQTFGRAR TMLDVMHNTP FTDMNDSEGE TQSMGYEAFA SAGRVLDLLA SLVGQISIDP 370 380 390 400 410 420 ERVDQNIRRS CITITELADS LVRIEDLSFR QAHEIAATVA KSVVALKGDL PNDGYQPFLG 430 440 450 460 470 480 AFSGLTGRET GIDEEKFRQI VSPEHFVAVR SRFGGPAPEP MREAFAAYRG KLGAFEAEAQ 490 500 RSTNHEAAKA AELAEKFTAL TGAR

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007870 Genomic DNA. Translation: AAK88796.2. Different initiation.
PIR	AG3128. B98159.
RefSeq	NP_356011.2. NC_003063.2.
3D structure databases
ProteinModelPortal	Q8U705.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8U705.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1136525.
GenomeReviews	Gene locus Atu4651 in contig AE007870_GR.
KEGG	atu:Atu4651.
PATRIC	20818722. VBIAgrTum91616_4456.
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	KELHELC.
PhylomeDB	Q8U705.
ProtClustDB	CLSK950150.
Enzyme and pathway databases
BioCyc	ATUM176299-1:ATU4651-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY2_AGRT5

Accession

Primary (citable) accession number: Q8U705

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program