Q8U544 (URED_AGRT5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreD

Gene names

Name:	ureD
Ordered Locus Names:	Atu2408
ORF Names:	AGR_C_4369

Organism

Agrobacterium tumefaciens (strain C58 / ATCC 33970)

Taxonomic identifier

176299 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. HAMAP MF_01384
Subunit structure	UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01384.
Sequence similarities	Belongs to the UreD family.
Sequence caution	The sequence AAK88144.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Urease accessory protein UreD HAMAP MF_01384		PRO_0000340403

Sequences

	Sequence		Length	Mass (Da)
	Q8U544 [UniParc]. Last modified June 10, 2008. Version 3. Checksum: 6B7BE2339CBB1571	FASTA	284	30,448
	10 20 30 40 50 60 MQSEQQAIGA SGCEDAQQPV RQQRARGRGR IVTKAVEGRS RLDELFQEGC AKIRLPDTFS 70 80 90 100 110 120 NEAEAILINS SGGLTGGDDI EWQATAGAGT SLVVTTQACE KVYKASSGTA TVTARISAGP 130 140 150 160 170 180 GAKLHWLPQE TILFDRASLN RRLEADLDQS SEFIAVEAVL LGRQAMGEAM THGLFRDRWR 190 200 210 220 230 240 IRHGGRLVHA EELLLEGEVA ELTAKPAVLA GQVAFATLLY IGPLSEALLP KIRAIAGESG 250 260 270 280 GASEWQGKLV VRVSAADGFS LRKLLFPIIS LLRNGAPVPK VWNL

References

[1]

"The genome of the natural genetic engineer Agrobacterium tumefaciens C58." Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W. Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

[2]

"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58." Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S. Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C58 / ATCC 33970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007869 Genomic DNA. Translation: AAK88144.2. Different initiation.
RefSeq	NP_355359.2. NC_003062.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8U544.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1134446.
GenomeReviews	Gene locus Atu2408 in contig AE007869_GR.
KEGG	atu:Atu2408.
PATRIC	20814597. VBIAgrTum91616_2417.
Phylogenomic databases
eggNOG	COG0829.
HOGENOM	HBG711156.
OMA	QETILFD.
Family and domain databases
HAMAP	MF_01384. UreD. [Tree]
InterPro	IPR002669. UreD. [Graphical view]
KO	K03190.
Pfam	PF01774. UreD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URED_AGRT5

Accession

Primary (citable) accession number: Q8U544

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program