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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi195 – 1951ZincUniRule annotation
Metal bindingi210 – 2101ZincUniRule annotation
Metal bindingi213 – 2131ZincUniRule annotation
Metal bindingi216 – 2161ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 1911ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
Archaeosine biosynthesis protein QueCUniRule annotation
PreQ(0) synthaseUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:PF0048
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2402407-cyano-7-deazaguanine synthasePRO_0000246986Add
BLAST

Proteomic databases

PRIDEiQ8U4N3.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0048.

Structurei

3D structure databases

ProteinModelPortaliQ8U4N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiVFIKSMN.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U4N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRAVVLFS GGLDSTACLY WAKKQYDEVI MLTVNYGSNE ERVTNKVAEY
60 70 80 90 100
FSKELDVRLK IVKLDFLKEF SEIRGSSLVG GEVPRVTAEE LEDIEKASET
110 120 130 140 150
ARSVWIPARN LVLISVAASL LDALGGGDII VGFNAEEATT FPDNSREFVE
160 170 180 190 200
KLNEALRFAT LNPVKVVAPL IDLDKRGIAK LLKELNAKYE YSNSCYNPKG
210 220 230 240
FTEDGRPIHC GECESCVRRH KGLIEGIGED KTVYAITPRI
Length:240
Mass (Da):26,726
Last modified:June 1, 2002 - v1
Checksum:i85AC6C9613D90AAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80172.1.
RefSeqiWP_011011160.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80172; AAL80172; PF0048.
GeneIDi1467877.
KEGGipfu:PF0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80172.1.
RefSeqiWP_011011160.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U4N3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0048.

Proteomic databases

PRIDEiQ8U4N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80172; AAL80172; PF0048.
GeneIDi1467877.
KEGGipfu:PF0048.

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiVFIKSMN.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC_PYRFU
AccessioniPrimary (citable) accession number: Q8U4N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.