ID   Q8U4M1_PYRFU            Unreviewed;       402 AA.
AC   Q8U4M1;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=NOP5/NOP56 related protein {ECO:0000313|EMBL:AAL80184.1};
GN   OrderedLocusNames=PF0060 {ECO:0000313|EMBL:AAL80184.1};
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL80184.1, ECO:0000313|Proteomes:UP000001013};
RN   [1] {ECO:0000313|EMBL:AAL80184.1, ECO:0000313|Proteomes:UP000001013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC   {ECO:0000313|Proteomes:UP000001013};
RX   PubMed=10430560;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2] {ECO:0007829|PDB:2NNW}
RP   X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 1-366.
RX   PubMed=17617422; DOI=10.1016/j.jmb.2007.06.029;
RA   Oruganti S., Zhang Y., Li H., Robinson H., Terns M.P., Terns R.M., Yang W.,
RA   Li H.;
RT   "Alternative conformations of the archaeal Nop56/58-fibrillarin complex
RT   imply flexibility in box C/D RNPs.";
RL   J. Mol. Biol. 371:1141-1150(2007).
RN   [3] {ECO:0007829|PDB:3NMU, ECO:0007829|PDB:3NVI}
RP   X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 1-369 IN COMPLEX WITH IRON-SULFUR
RP   (4FE-4S-S-ADOMET).
RX   PubMed=20864039; DOI=10.1016/j.molcel.2010.08.022;
RA   Xue S., Wang R., Yang F., Terns R.M., Terns M.P., Zhang X., Maxwell E.S.,
RA   Li H.;
RT   "Structural basis for substrate placement by an archaeal box C/D
RT   ribonucleoprotein particle.";
RL   Mol. Cell 39:939-949(2010).
RN   [4] {ECO:0007829|PDB:4BY9}
RP   STRUCTURE BY NMR OF 4-369.
RX   PubMed=24121435; DOI=10.1038/NATURE12581;
RA   Lapinaite A., Simon B., Skjaerven L., Rakwalska-Bange M., Gabel F.,
RA   Carlomagno T.;
RT   "The structure of the box C/D enzyme reveals regulation of RNA
RT   methylation.";
RL   Nature 502:519-523(2013).
CC   -!- INTERACTION:
CC       Q8U4M1; Q8U4M2; NbExp=7; IntAct=EBI-16078570, EBI-16078587;
CC   -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC       {ECO:0000256|ARBA:ARBA00009211}.
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DR   EMBL; AE009950; AAL80184.1; -; Genomic_DNA.
DR   RefSeq; WP_011011172.1; NZ_CP023154.1.
DR   PDB; 2NNW; X-ray; 2.70 A; A/C=1-366.
DR   PDB; 3NMU; X-ray; 2.73 A; A/B=1-369.
DR   PDB; 3NVI; X-ray; 2.71 A; A/C=1-369.
DR   PDB; 3NVK; X-ray; 3.21 A; A/F=1-363.
DR   PDB; 3NVM; X-ray; 3.41 A; A=1-369.
DR   PDB; 4BY9; NMR; -; C/F/I/L=4-369.
DR   PDBsum; 2NNW; -.
DR   PDBsum; 3NMU; -.
DR   PDBsum; 3NVI; -.
DR   PDBsum; 3NVK; -.
DR   PDBsum; 3NVM; -.
DR   PDBsum; 4BY9; -.
DR   AlphaFoldDB; Q8U4M1; -.
DR   SASBDB; Q8U4M1; -.
DR   SMR; Q8U4M1; -.
DR   DIP; DIP-60605N; -.
DR   IntAct; Q8U4M1; 1.
DR   STRING; 186497.PF0060; -.
DR   PaxDb; 186497-PF0060; -.
DR   DNASU; 1467889; -.
DR   GeneID; 41711847; -.
DR   KEGG; pfu:PF0060; -.
DR   PATRIC; fig|186497.12.peg.64; -.
DR   eggNOG; arCOG01923; Archaea.
DR   HOGENOM; CLU_015495_1_0_2; -.
DR   OrthoDB; 11877at2157; -.
DR   PhylomeDB; Q8U4M1; -.
DR   EvolutionaryTrace; Q8U4M1; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR   Gene3D; 1.10.150.460; -; 1.
DR   Gene3D; 3.30.420.220; -; 1.
DR   Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR   Gene3D; 1.10.246.90; Nop domain; 1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR045056; Nop56/Nop58.
DR   InterPro; IPR048896; Nop5_56-rel_N.
DR   InterPro; IPR047099; Nop5_N_sf.
DR   InterPro; IPR042239; Nop_C.
DR   InterPro; IPR002687; Nop_dom.
DR   InterPro; IPR036070; Nop_dom_sf.
DR   InterPro; IPR012976; NOSIC.
DR   PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR   PANTHER; PTHR10894:SF0; NUCLEOLAR PROTEIN 56; 1.
DR   Pfam; PF01798; Nop; 1.
DR   Pfam; PF21572; Nop5_56-rel_N_Arc; 1.
DR   SMART; SM00931; NOSIC; 1.
DR   SUPFAM; SSF89124; Nop domain; 1.
DR   PROSITE; PS51358; NOP; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2NNW, ECO:0007829|PDB:3NMU};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001013}.
FT   DOMAIN          252..367
FT                   /note="Nop"
FT                   /evidence="ECO:0000259|PROSITE:PS51358"
FT   REGION          365..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..402
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  46788 MW;  898FA9AA195CD911 CRC64;
     MKAFISENVR GIYAFDENGN LIEKRYFTDK PEKVLDQLLK GEITKDLEEL LNSLKEKGYD
     EFVFEHPELS RRAKELGFSA TTEFPNIAGE RLRSNPEEFL GENWFEEYYK VGVALTRMRI
     QEQSGARDKM VIQAIEALDD VDKVINLLVA RLREWYSLHF PELDELLPKH PQYVAFVKTV
     GHRDNINEEV LRELGLSEEK IKKILEAKEK TMGAWMDQTD IEVVRQLAEE IDRLYQLRKK
     LEDYIDRAMD DVAPNLKALV GAKLAARLIS LAGGLRELAM MPSSTIQVLG AEKALFRHLR
     TGAKPPKHGV IYQYPAINRS PWWQRGKIAR ALAGKLAIAA RVDYFSGEYI AEELKKELEA
     RIREIKEKYP KPPKRKREER KGKKPWKKDK KKKKKKEKPR RR
//