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Q8U4M1

- Q8U4M1_PYRFU

UniProt

Q8U4M1 - Q8U4M1_PYRFU

Protein
Submitted name:

NOP5/NOP56 related protein

Gene

PF0060

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi348 – 3481Iron-sulfur(4Fe-4S-S-AdoMet)Imported
    Metal bindingi349 – 3491Iron-sulfur(4Fe-4S-S-AdoMet); via amide nitrogenImported

    Keywords - Ligandi

    Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NOP5/NOP56 related proteinImported
    Gene namesi
    Ordered Locus Names:PF0060Imported
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8U4M1.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60605N.
    STRINGi186497.PF0060.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NNWX-ray2.70A/C1-366[»]
    3NMUX-ray2.73A/B1-369[»]
    3NVIX-ray2.71A/C1-369[»]
    3NVKX-ray3.21A/F1-363[»]
    3NVMX-ray3.41A1-369[»]
    4BY9NMR-C/F/I/L4-369[»]
    ProteinModelPortaliQ8U4M1.
    SMRiQ8U4M1. Positions 4-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8U4M1.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1498.
    HOGENOMiHOG000227188.
    KOiK14564.
    OMAiWMDETDI.

    Family and domain databases

    InterProiIPR002687. Nop_dom.
    IPR012976. NOSIC.
    [Graphical view]
    PfamiPF01798. Nop. 1 hit.
    PF08060. NOSIC. 1 hit.
    [Graphical view]
    SMARTiSM00931. NOSIC. 1 hit.
    [Graphical view]
    PROSITEiPS51358. NOP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8U4M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAFISENVR GIYAFDENGN LIEKRYFTDK PEKVLDQLLK GEITKDLEEL    50
    LNSLKEKGYD EFVFEHPELS RRAKELGFSA TTEFPNIAGE RLRSNPEEFL 100
    GENWFEEYYK VGVALTRMRI QEQSGARDKM VIQAIEALDD VDKVINLLVA 150
    RLREWYSLHF PELDELLPKH PQYVAFVKTV GHRDNINEEV LRELGLSEEK 200
    IKKILEAKEK TMGAWMDQTD IEVVRQLAEE IDRLYQLRKK LEDYIDRAMD 250
    DVAPNLKALV GAKLAARLIS LAGGLRELAM MPSSTIQVLG AEKALFRHLR 300
    TGAKPPKHGV IYQYPAINRS PWWQRGKIAR ALAGKLAIAA RVDYFSGEYI 350
    AEELKKELEA RIREIKEKYP KPPKRKREER KGKKPWKKDK KKKKKKEKPR 400
    RR 402
    Length:402
    Mass (Da):46,788
    Last modified:June 1, 2002 - v1
    Checksum:i898FA9AA195CD911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL80184.1.
    RefSeqiNP_577789.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL80184; AAL80184; PF0060.
    GeneIDi1467889.
    KEGGipfu:PF0060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL80184.1 .
    RefSeqi NP_577789.1. NC_003413.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NNW X-ray 2.70 A/C 1-366 [» ]
    3NMU X-ray 2.73 A/B 1-369 [» ]
    3NVI X-ray 2.71 A/C 1-369 [» ]
    3NVK X-ray 3.21 A/F 1-363 [» ]
    3NVM X-ray 3.41 A 1-369 [» ]
    4BY9 NMR - C/F/I/L 4-369 [» ]
    ProteinModelPortali Q8U4M1.
    SMRi Q8U4M1. Positions 4-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60605N.
    STRINGi 186497.PF0060.

    Proteomic databases

    PRIDEi Q8U4M1.

    Protocols and materials databases

    DNASUi 1467889.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL80184 ; AAL80184 ; PF0060 .
    GeneIDi 1467889.
    KEGGi pfu:PF0060.

    Phylogenomic databases

    eggNOGi COG1498.
    HOGENOMi HOG000227188.
    KOi K14564.
    OMAi WMDETDI.

    Miscellaneous databases

    EvolutionaryTracei Q8U4M1.

    Family and domain databases

    InterProi IPR002687. Nop_dom.
    IPR012976. NOSIC.
    [Graphical view ]
    Pfami PF01798. Nop. 1 hit.
    PF08060. NOSIC. 1 hit.
    [Graphical view ]
    SMARTi SM00931. NOSIC. 1 hit.
    [Graphical view ]
    PROSITEi PS51358. NOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1Imported.
    2. "Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs."
      Oruganti S., Zhang Y., Li H., Robinson H., Terns M.P., Terns R.M., Yang W., Li H.
      J. Mol. Biol. 371:1141-1150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 1-366.
    3. "Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle."
      Xue S., Wang R., Yang F., Terns R.M., Terns M.P., Zhang X., Maxwell E.S., Li H.
      Mol. Cell 39:939-949(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 1-369 IN COMPLEX WITH IRON-SULFUR(4FE-4S-S-ADOMET).
    4. "The structure of the box C/D enzyme reveals regulation of RNA methylation."
      Lapinaite A., Simon B., Skjaerven L., Rakwalska-Bange M., Gabel F., Carlomagno T.
      Nature 502:519-523(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 4-369.

    Entry informationi

    Entry nameiQ8U4M1_PYRFU
    AccessioniPrimary (citable) accession number: Q8U4M1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3