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Protein

Molybdate/tungstate-binding protein WtpA

Gene

wtpA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Molybdate or tungstate; via amide nitrogen1 Publication1
Metal bindingi42Molybdate or tungstate1 Publication1
Metal bindingi75Molybdate or tungstate1 Publication1
Metal bindingi160Molybdate or tungstate1 Publication1
Metal bindingi162Molybdate or tungstate; via amide nitrogen1 Publication1
Metal bindingi218Molybdate or tungstate1 Publication1
Metal bindingi236Molybdate or tungstate1 Publication1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandMetal-binding, Molybdenum, Tungsten

Enzyme and pathway databases

BRENDAi3.6.3.55 5243

Protein family/group databases

TCDBi3.A.1.6.5 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate-binding protein WtpACurated
Gene namesi
Name:wtpA1 Publication
Ordered Locus Names:PF0080
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000015972328 – 345Molybdate/tungstate-binding protein WtpAAdd BLAST318

Proteomic databases

PRIDEiQ8U4K5

Interactioni

Subunit structurei

Monomer (PubMed:16952940). The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA) (Probable).Curated1 Publication

Protein-protein interaction databases

STRINGi186497.PF0080

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 40Combined sources8
Helixi41 – 43Combined sources3
Helixi44 – 62Combined sources19
Beta strandi66 – 73Combined sources8
Helixi75 – 83Combined sources9
Beta strandi90 – 96Combined sources7
Helixi99 – 103Combined sources5
Turni104 – 108Combined sources5
Beta strandi113 – 117Combined sources5
Beta strandi120 – 124Combined sources5
Helixi131 – 136Combined sources6
Helixi138 – 140Combined sources3
Helixi141 – 145Combined sources5
Beta strandi152 – 155Combined sources4
Turni157 – 159Combined sources3
Helixi161 – 177Combined sources17
Helixi181 – 185Combined sources5
Turni186 – 189Combined sources4
Beta strandi193 – 195Combined sources3
Beta strandi198 – 201Combined sources4
Turni209 – 211Combined sources3
Beta strandi212 – 217Combined sources6
Helixi218 – 221Combined sources4
Helixi222 – 226Combined sources5
Beta strandi229 – 236Combined sources8
Helixi237 – 242Combined sources6
Beta strandi246 – 249Combined sources4
Turni252 – 254Combined sources3
Helixi259 – 261Combined sources3
Helixi262 – 265Combined sources4
Beta strandi269 – 272Combined sources4
Turni273 – 275Combined sources3
Beta strandi278 – 280Combined sources3
Beta strandi285 – 290Combined sources6
Helixi297 – 308Combined sources12
Helixi310 – 318Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CG1X-ray1.60A/B32-324[»]
ProteinModelPortaliQ8U4K5
SMRiQ8U4K5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U4K5

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiarCOG00219 Archaea
COG0725 LUCA
HOGENOMiHOG000237153
KOiK15495
OMAiKDAPNRE
OrthoDBiPOG093Z05YM

Family and domain databases

InterProiView protein in InterPro
IPR022498 ABC_trnspt_W-bd_WtpA
TIGRFAMsiTIGR03730 tungstate_WtpA, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8U4K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREGGVMKKR LLALIVAFAV LTAGCLGSES KEVTLIVFHA GSLSVPFQEV
60 70 80 90 100
EKEFSEYAER NLGIKVSFQD EASGSVMAVR KVTDLGRKAD VIGVADYTLI
110 120 130 140 150
PQLLIPNYTD FYVLFATNEI VIAFTDKSRY VEEMKSNPDK WYEILAREDV
160 170 180 190 200
RFGFSDPNQD PCGYRSLMVI KLADLYYGKE IFKELIEENT NIYSNGTQIY
210 220 230 240 250
APKEITVNPG KIVIRPKETD LLGLVESGSI DYIFIYKSVA KQHNLSYITL
260 270 280 290 300
PSEINLGDFS KEKFYGQISI TLGSTGKTIK AKPIVYGVTV LKDAPNREVA
310 320 330 340
IEFLRYLLSE NGKRIFEKNH QDFLEPPIAF GNVPEELKPL VSIEK
Length:345
Mass (Da):38,801
Last modified:June 1, 2002 - v1
Checksum:iFC52F08CFA995DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL80204.1

Genome annotation databases

EnsemblBacteriaiAAL80204; AAL80204; PF0080
KEGGipfu:PF0080
PATRICifig|186497.12.peg.84

Similar proteinsi

Entry informationi

Entry nameiWTPA_PYRFU
AccessioniPrimary (citable) accession number: Q8U4K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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