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Protein

Molybdate/tungstate-binding protein WtpA

Gene

wtpA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Molybdate or tungstate; via amide nitrogen1 Publication
Metal bindingi42 – 421Molybdate or tungstate1 Publication
Metal bindingi75 – 751Molybdate or tungstate1 Publication
Metal bindingi160 – 1601Molybdate or tungstate1 Publication
Metal bindingi162 – 1621Molybdate or tungstate; via amide nitrogen1 Publication
Metal bindingi218 – 2181Molybdate or tungstate1 Publication
Metal bindingi236 – 2361Molybdate or tungstate1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Molybdenum, Tungsten

Enzyme and pathway databases

BRENDAi3.6.3.55. 5243.

Protein family/group databases

TCDBi3.A.1.6.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate-binding protein WtpACurated
Gene namesi
Name:wtpA1 Publication
Ordered Locus Names:PF0080
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 345318Molybdate/tungstate-binding protein WtpAPRO_0000159723Add
BLAST

Proteomic databases

PRIDEiQ8U4K5.

Interactioni

Subunit structurei

Monomer (PubMed:16952940). The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA) (Probable).Curated1 Publication

Protein-protein interaction databases

STRINGi186497.PF0080.

Structurei

Secondary structure

1
345
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 408Combined sources
Helixi41 – 433Combined sources
Helixi44 – 6219Combined sources
Beta strandi66 – 738Combined sources
Helixi75 – 839Combined sources
Beta strandi90 – 967Combined sources
Helixi99 – 1035Combined sources
Turni104 – 1085Combined sources
Beta strandi113 – 1175Combined sources
Beta strandi120 – 1245Combined sources
Helixi131 – 1366Combined sources
Helixi138 – 1403Combined sources
Helixi141 – 1455Combined sources
Beta strandi152 – 1554Combined sources
Turni157 – 1593Combined sources
Helixi161 – 17717Combined sources
Helixi181 – 1855Combined sources
Turni186 – 1894Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi198 – 2014Combined sources
Turni209 – 2113Combined sources
Beta strandi212 – 2176Combined sources
Helixi218 – 2214Combined sources
Helixi222 – 2265Combined sources
Beta strandi229 – 2368Combined sources
Helixi237 – 2426Combined sources
Beta strandi246 – 2494Combined sources
Turni252 – 2543Combined sources
Helixi259 – 2613Combined sources
Helixi262 – 2654Combined sources
Beta strandi269 – 2724Combined sources
Turni273 – 2753Combined sources
Beta strandi278 – 2803Combined sources
Beta strandi285 – 2906Combined sources
Helixi297 – 30812Combined sources
Helixi310 – 3189Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CG1X-ray1.60A/B32-324[»]
ProteinModelPortaliQ8U4K5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U4K5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
HOGENOMiHOG000237153.
KOiK15495.
OMAiVADYTLI.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8U4K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREGGVMKKR LLALIVAFAV LTAGCLGSES KEVTLIVFHA GSLSVPFQEV
60 70 80 90 100
EKEFSEYAER NLGIKVSFQD EASGSVMAVR KVTDLGRKAD VIGVADYTLI
110 120 130 140 150
PQLLIPNYTD FYVLFATNEI VIAFTDKSRY VEEMKSNPDK WYEILAREDV
160 170 180 190 200
RFGFSDPNQD PCGYRSLMVI KLADLYYGKE IFKELIEENT NIYSNGTQIY
210 220 230 240 250
APKEITVNPG KIVIRPKETD LLGLVESGSI DYIFIYKSVA KQHNLSYITL
260 270 280 290 300
PSEINLGDFS KEKFYGQISI TLGSTGKTIK AKPIVYGVTV LKDAPNREVA
310 320 330 340
IEFLRYLLSE NGKRIFEKNH QDFLEPPIAF GNVPEELKPL VSIEK
Length:345
Mass (Da):38,801
Last modified:June 1, 2002 - v1
Checksum:iFC52F08CFA995DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80204.1.

Genome annotation databases

EnsemblBacteriaiAAL80204; AAL80204; PF0080.
KEGGipfu:PF0080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80204.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CG1X-ray1.60A/B32-324[»]
ProteinModelPortaliQ8U4K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0080.

Protein family/group databases

TCDBi3.A.1.6.5. the atp-binding cassette (abc) superfamily.

Proteomic databases

PRIDEiQ8U4K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80204; AAL80204; PF0080.
KEGGipfu:PF0080.

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
HOGENOMiHOG000237153.
KOiK15495.
OMAiVADYTLI.

Enzyme and pathway databases

BRENDAi3.6.3.55. 5243.

Miscellaneous databases

EvolutionaryTraceiQ8U4K5.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWTPA_PYRFU
AccessioniPrimary (citable) accession number: Q8U4K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: February 17, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.