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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei593For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PF0157
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354302 – 598Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST597

Proteomic databases

PRIDEiQ8U4D1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0157.

Structurei

3D structure databases

ProteinModelPortaliQ8U4D1.
SMRiQ8U4D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini280 – 420SIS 1UniRule annotationAdd BLAST141
Domaini449 – 588SIS 2UniRule annotationAdd BLAST140

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiarCOG00057. Archaea.
COG0449. LUCA.
HOGENOMiHOG000258898.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG093Z014P.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8U4D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIIGYIGP RRASPILVEG LKRLEYRGYD SAGIAVLNEG RIEIRKGAGK
60 70 80 90 100
IDELVGKLKF QEIPGNIGIG HTRWATHGVP NDINAHPHTD CTGKIVVVHN
110 120 130 140 150
GIVENFHELK EELLKKGHVF RSDTDTELIA HLIEENLRII KNFEDAFRMA
160 170 180 190 200
LLRLKGSYAL VVLFADDPER LYIARKDSPL IIGIGNGEMF VASDIPAFLA
210 220 230 240 250
YTNKAVFLDD GEYGIVSRYE FIVKDIVTGF PKIKDVVTIS WTLEMAEKGG
260 270 280 290 300
FDHFMLKEIY EQPRAIKDAI YGNIEAIKEV AEVVSNYDKI IMIGMGTSYH
310 320 330 340 350
AALVGKYLFQ RFTKTPVIVE EASEFRYEYE DIIDKDTLVV AITQSGETAD
360 370 380 390 400
TVAGIKLAKN KGAKVLGIVN VVGSLATRIA DITLYTHAGP EIGVAATKTY
410 420 430 440 450
TTQLMVLTLL AMELGKKIGT DVSEIENILP RLPEIIDSAL GLNEKIKGIA
460 470 480 490 500
KNILPKHDLF YIGRGINVPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA
510 520 530 540 550
LIEEGVPVIS IAPSGKTFEK MLSNIEEAKA RGGYIISLGD DIRLSEISDE
560 570 580 590
WIRLPKLPEE ITPIVYIVPL QLLAYHLAVL RGNNPDRPRN LAKSVTVE
Length:598
Mass (Da):65,884
Last modified:January 23, 2007 - v3
Checksum:i7896717DB2143121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80281.1.
RefSeqiWP_011011270.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80281; AAL80281; PF0157.
GeneIDi1467989.
KEGGipfu:PF0157.
PATRICifig|186497.12.peg.163.

Similar proteinsi

Entry informationi

Entry nameiGLMS_PYRFU
AccessioniPrimary (citable) accession number: Q8U4D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome