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Q8U4D1

- GLMS_PYRFU

UniProt

Q8U4D1 - GLMS_PYRFU

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, PF0157
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei593 – 5931For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PF0157
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135430Add
BLAST

Proteomic databases

PRIDEiQ8U4D1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0157.

Structurei

3D structure databases

ProteinModelPortaliQ8U4D1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2Add
BLAST
Domaini280 – 420141SIS 1Add
BLAST
Domaini449 – 588140SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiHAESYPA.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8U4D1-1 [UniParc]FASTAAdd to Basket

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MCGIIGYIGP RRASPILVEG LKRLEYRGYD SAGIAVLNEG RIEIRKGAGK    50
IDELVGKLKF QEIPGNIGIG HTRWATHGVP NDINAHPHTD CTGKIVVVHN 100
GIVENFHELK EELLKKGHVF RSDTDTELIA HLIEENLRII KNFEDAFRMA 150
LLRLKGSYAL VVLFADDPER LYIARKDSPL IIGIGNGEMF VASDIPAFLA 200
YTNKAVFLDD GEYGIVSRYE FIVKDIVTGF PKIKDVVTIS WTLEMAEKGG 250
FDHFMLKEIY EQPRAIKDAI YGNIEAIKEV AEVVSNYDKI IMIGMGTSYH 300
AALVGKYLFQ RFTKTPVIVE EASEFRYEYE DIIDKDTLVV AITQSGETAD 350
TVAGIKLAKN KGAKVLGIVN VVGSLATRIA DITLYTHAGP EIGVAATKTY 400
TTQLMVLTLL AMELGKKIGT DVSEIENILP RLPEIIDSAL GLNEKIKGIA 450
KNILPKHDLF YIGRGINVPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA 500
LIEEGVPVIS IAPSGKTFEK MLSNIEEAKA RGGYIISLGD DIRLSEISDE 550
WIRLPKLPEE ITPIVYIVPL QLLAYHLAVL RGNNPDRPRN LAKSVTVE 598
Length:598
Mass (Da):65,884
Last modified:January 23, 2007 - v3
Checksum:i7896717DB2143121
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL80281.1.
RefSeqiNP_577886.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80281; AAL80281; PF0157.
GeneIDi1467989.
KEGGipfu:PF0157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL80281.1 .
RefSeqi NP_577886.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8U4D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF0157.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PRIDEi Q8U4D1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL80281 ; AAL80281 ; PF0157 .
GeneIDi 1467989.
KEGGi pfu:PF0157.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi HAESYPA.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiGLMS_PYRFU
AccessioniPrimary (citable) accession number: Q8U4D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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