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Protein

Protein-export membrane protein SecD

Gene

secD

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in protein export.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Protein family/group databases

TCDBi3.A.5.7.2. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-export membrane protein SecDUniRule annotation
Gene namesi
Name:secDUniRule annotation
Ordered Locus Names:PF0174
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei346 – 36621HelicalUniRule annotationAdd
BLAST
Transmembranei373 – 39321HelicalUniRule annotationAdd
BLAST
Transmembranei399 – 41921HelicalUniRule annotationAdd
BLAST
Transmembranei446 – 46621HelicalUniRule annotationAdd
BLAST
Transmembranei468 – 48821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Protein-export membrane protein SecDPRO_0000412688Add
BLAST

Proteomic databases

PRIDEiQ8U4B4.

Interactioni

Subunit structurei

Part of the protein translocation apparatus. Forms a complex with SecF.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0174.

Structurei

3D structure databases

ProteinModelPortaliQ8U4B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG03055. Archaea.
COG0342. LUCA.
HOGENOMiHOG000227492.
KOiK03072.
OMAiRMGRAFF.

Family and domain databases

HAMAPiMF_01463_A. SecD_A.
InterProiIPR022813. SecD/SecF_arch_bac.
IPR022646. SecD/SecF_CS.
IPR024912. SecD_arc.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U4B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWRRILLNF RVIVLIFFLL ISITALATRG LTFGLDISGG ISITVKLEKP
60 70 80 90 100
VDSQTMEQVK IALEQRLNTL GVKNIVVEPW GDQFVIVKVA NVTEEEADQL
110 120 130 140 150
IKTIERQGVF YAEFQGIIFA TGKDILNVGS VSYDPQHSAW VVPFRLSKEA
160 170 180 190 200
AEKFAQLALG KAGYPVDMFL DPPVNSTLVV SNRVYEAMLS KTFMLEGDMT
210 220 230 240 250
LVERIEKAFG IKVVPYANVT PEEIAEIAKG SERIILLDVD GNLSKALKEM
260 270 280 290 300
GFEVETRSMR SDEDVYDFIK RSLGLYGPYR VSEGLATGNP STEVMISITA
310 320 330 340 350
PKTDIQARQD AQVVSVVLRS GSLPVKLSIE RIDYISPKLG ENFKRQVLVA
360 370 380 390 400
GIAALLVVGL IVFLHYRKIK IAIPVMFTSF SEVLIILGIA ALIRWNLDLP
410 420 430 440 450
SIAGIIAAIG TGVDQQIVIT DELLGEEESR RRVKRSGVLR RMGRAFFIIL
460 470 480 490 500
ASATTTIVAM SFLFKFFVGG LRGFAFTTIL GVLVGIFITR PAYGEIAKVL

IGERR
Length:505
Mass (Da):55,814
Last modified:June 1, 2002 - v1
Checksum:iA06E2ED0B4A6B86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80298.1.
RefSeqiWP_011011287.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80298; AAL80298; PF0174.
GeneIDi1468006.
KEGGipfu:PF0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80298.1.
RefSeqiWP_011011287.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U4B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0174.

Protein family/group databases

TCDBi3.A.5.7.2. the general secretory pathway (sec) family.

Proteomic databases

PRIDEiQ8U4B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80298; AAL80298; PF0174.
GeneIDi1468006.
KEGGipfu:PF0174.

Phylogenomic databases

eggNOGiarCOG03055. Archaea.
COG0342. LUCA.
HOGENOMiHOG000227492.
KOiK03072.
OMAiRMGRAFF.

Family and domain databases

HAMAPiMF_01463_A. SecD_A.
InterProiIPR022813. SecD/SecF_arch_bac.
IPR022646. SecD/SecF_CS.
IPR024912. SecD_arc.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiSECD_PYRFU
AccessioniPrimary (citable) accession number: Q8U4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.