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Q8U484

- ASSY_PYRFU

UniProt

Q8U484 - ASSY_PYRFU

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841CitrullineUniRule annotation
Binding sitei114 – 1141ATP; via amide nitrogenUniRule annotation
Binding sitei116 – 1161AspartateUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei120 – 1201CitrullineUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei169 – 1691CitrullineUniRule annotation
Binding sitei178 – 1781CitrullineUniRule annotation
Binding sitei254 – 2541CitrullineUniRule annotation
Binding sitei266 – 2661CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:PF0207
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Argininosuccinate synthasePRO_0000148684Add
BLAST

Proteomic databases

PRIDEiQ8U484.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0207.

Structurei

3D structure databases

ProteinModelPortaliQ8U484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiRFESTIR.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U484-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIVLAYSGG LDTSVILKLM QEKLGAEVIT VTVDVGQKDD FEKIEEKAYK
60 70 80 90 100
FGAVKHYYID AKEEFAENYV CKAIKANALY ENAYPLSTAL ARPLIVEKLV
110 120 130 140 150
EVAKKEGAGI IAHGCTGKGN DQVRFNLGIK ALMPEAEILQ PVAEWNLTRD
160 170 180 190 200
WEMEYAKKHG IPVSDKIYSI DENIWGRSIE GGVLEDPSIE PPEEVFEWTV
210 220 230 240 250
SIEKAPDKPE YVTIGFENGV PVSLNGEKMK LLELILKLNE IAGKHGVGRI
260 270 280 290 300
DHIEDRSVGI KSREVYEAPA AVTLIKAHQD LEKLTLTKWV IEFKSIVDSK
310 320 330 340 350
WSWLVYNGLW YEPLRLALEG FIDEAEKAVN GEVTVKLWKG NAIVVGRKSD
360 370 380 390 400
NALYDVKMAT YEKFSTFDQK LAKGFIELFG MQSVLAYNML HGVHSTSNIS
410
EIKEAIKTLE
Length:410
Mass (Da):45,973
Last modified:June 1, 2002 - v1
Checksum:iBEF1CD6792295047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80331.1.
RefSeqiNP_577936.1. NC_003413.1.
WP_011011320.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80331; AAL80331; PF0207.
GeneIDi1468039.
KEGGipfu:PF0207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80331.1 .
RefSeqi NP_577936.1. NC_003413.1.
WP_011011320.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8U484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF0207.

Proteomic databases

PRIDEi Q8U484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL80331 ; AAL80331 ; PF0207 .
GeneIDi 1468039.
KEGGi pfu:PF0207.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi RFESTIR.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiASSY_PYRFU
AccessioniPrimary (citable) accession number: Q8U484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3