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Q8U484

- ASSY_PYRFU

UniProt

Q8U484 - ASSY_PYRFU

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Protein

Argininosuccinate synthase

Gene
argG, PF0207
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Citrulline By similarity
Binding sitei114 – 1141ATP; via amide nitrogen By similarity
Binding sitei116 – 1161Aspartate By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei120 – 1201Citrulline By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei169 – 1691Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei254 – 2541Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:PF0207
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Argininosuccinate synthaseUniRule annotationPRO_0000148684Add
BLAST

Proteomic databases

PRIDEiQ8U484.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0207.

Structurei

3D structure databases

ProteinModelPortaliQ8U484.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiRFESTIR.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U484-1 [UniParc]FASTAAdd to Basket

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MRIVLAYSGG LDTSVILKLM QEKLGAEVIT VTVDVGQKDD FEKIEEKAYK    50
FGAVKHYYID AKEEFAENYV CKAIKANALY ENAYPLSTAL ARPLIVEKLV 100
EVAKKEGAGI IAHGCTGKGN DQVRFNLGIK ALMPEAEILQ PVAEWNLTRD 150
WEMEYAKKHG IPVSDKIYSI DENIWGRSIE GGVLEDPSIE PPEEVFEWTV 200
SIEKAPDKPE YVTIGFENGV PVSLNGEKMK LLELILKLNE IAGKHGVGRI 250
DHIEDRSVGI KSREVYEAPA AVTLIKAHQD LEKLTLTKWV IEFKSIVDSK 300
WSWLVYNGLW YEPLRLALEG FIDEAEKAVN GEVTVKLWKG NAIVVGRKSD 350
NALYDVKMAT YEKFSTFDQK LAKGFIELFG MQSVLAYNML HGVHSTSNIS 400
EIKEAIKTLE 410
Length:410
Mass (Da):45,973
Last modified:June 1, 2002 - v1
Checksum:iBEF1CD6792295047
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL80331.1.
RefSeqiNP_577936.1. NC_003413.1.
WP_011011320.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80331; AAL80331; PF0207.
GeneIDi1468039.
KEGGipfu:PF0207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL80331.1 .
RefSeqi NP_577936.1. NC_003413.1.
WP_011011320.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8U484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF0207.

Proteomic databases

PRIDEi Q8U484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL80331 ; AAL80331 ; PF0207 .
GeneIDi 1468039.
KEGGi pfu:PF0207.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi RFESTIR.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiASSY_PYRFU
AccessioniPrimary (citable) accession number: Q8U484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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