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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:PF0241
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367291 – 385Tryptophan--tRNA ligaseAdd BLAST385

Proteomic databases

PRIDEiQ8U453

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0241

Structurei

3D structure databases

ProteinModelPortaliQ8U453
SMRiQ8U453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 90"HIGH" region9
Motifi253 – 257"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEFKVTPW EVEGIIDYNK LIEQFGTSPL TDDLLERTAR LTKSELPIFF
60 70 80 90 100
RRKFFFSHRD YDKVLDDYEQ GKGFFLYTGR GPSGPMHIGH IIPFFATKWL
110 120 130 140 150
QEKFDVNLYI QITDDEKFLF KENLTFEDTK YWAYQNILDI IAVGFDPDKT
160 170 180 190 200
FIFQNSEFTK IYEMAIPIAK KINFSMAKAV FGFTEQSKIG MIFFPAIQAA
210 220 230 240 250
PTFFEKKRCL IPAAIDQDPY WRLQRDFAES LGYYKTAALH SKFFPPLTGL
260 270 280 290 300
EGKMSASKPE TAIYLTDNPE EAGKKIWKFA LTGGQPTLKE QREKGGNPEK
310 320 330 340 350
CVVFKWLEIF FEPDDKKLME RYYACKNGEL LCGECKRYLI QRVQEFLKEH
360 370 380
QEKRKKAEKL VEKFKYTGKL AQEQWNKAIP DPLKK
Length:385
Mass (Da):45,178
Last modified:June 1, 2002 - v1
Checksum:i3A7A628958200CCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL80365.1
RefSeqiWP_011011356.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL80365; AAL80365; PF0241
GeneIDi1468075
KEGGipfu:PF0241
PATRICifig|186497.12.peg.251

Similar proteinsi

Entry informationi

Entry nameiSYW_PYRFU
AccessioniPrimary (citable) accession number: Q8U453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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