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Protein

Glyoxylate reductase

Gene

gyaR

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1
Active sitei270UniRule annotation1
Active sitei288Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPUniRule annotation4
Nucleotide bindingi180 – 182NADPUniRule annotation3
Nucleotide bindingi239 – 241NADPUniRule annotation3
Nucleotide bindingi288 – 290NADPUniRule annotation3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17245.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductaseUniRule annotation (EC:1.1.1.26UniRule annotation)
Gene namesi
Name:gyaRUniRule annotation
Ordered Locus Names:PF0319
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759481 – 336Glyoxylate reductaseAdd BLAST336

Proteomic databases

PRIDEiQ8U3Y2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0319.

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi13 – 20Combined sources8
Beta strandi23 – 27Combined sources5
Helixi36 – 42Combined sources7
Helixi43 – 45Combined sources3
Beta strandi47 – 51Combined sources5
Helixi59 – 63Combined sources5
Beta strandi70 – 76Combined sources7
Helixi83 – 88Combined sources6
Beta strandi92 – 94Combined sources3
Helixi101 – 117Combined sources17
Helixi119 – 127Combined sources9
Helixi130 – 134Combined sources5
Turni140 – 143Combined sources4
Beta strandi152 – 157Combined sources6
Helixi160 – 170Combined sources11
Turni171 – 173Combined sources3
Beta strandi175 – 179Combined sources5
Helixi185 – 191Combined sources7
Helixi198 – 204Combined sources7
Beta strandi206 – 210Combined sources5
Turni216 – 220Combined sources5
Helixi224 – 229Combined sources6
Beta strandi235 – 238Combined sources4
Helixi242 – 244Combined sources3
Helixi247 – 255Combined sources9
Beta strandi258 – 265Combined sources8
Beta strandi268 – 271Combined sources4
Helixi275 – 278Combined sources4
Beta strandi283 – 285Combined sources3
Helixi294 – 312Combined sources19
Helixi325 – 328Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AOVX-ray1.40A1-336[»]
ProteinModelPortaliQ8U3Y2.
SMRiQ8U3Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U3Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKVFITRA IPENGINMLE EEFEVEVWEE EREIPREKLL EKVKDVDALV
60 70 80 90 100
TMLSERIDQE VFENAPRLRI VANYAVGYDN IDVEEATRRG IYVTNTPDVL
110 120 130 140 150
TNATADHAFA LLLATARHVV KGDKFVRSGE WKRKGIAWHP KWFLGYELYG
160 170 180 190 200
KTIGIVGFGR IGQAIARRAK GFNMRILYYS RTRKSQAEKE LGAEYRPLEE
210 220 230 240 250
VLKESDFVIL AVPLTKETMY MINEERLKLM KPTAILVNIA RGKVVDTKAL
260 270 280 290 300
IKALKEGWIA GAGLDVFEEE PYYNEELFSL DNVVLTPHIG SATFEAREAM
310 320 330
AELVARNLIA FKRGEIPPTL VNKEVIKIRK PGFNEQ
Length:336
Mass (Da):38,342
Last modified:June 1, 2002 - v1
Checksum:iCFC48402FD2073B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80443.1.
RefSeqiWP_011011434.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80443; AAL80443; PF0319.
GeneIDi1468154.
KEGGipfu:PF0319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80443.1.
RefSeqiWP_011011434.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AOVX-ray1.40A1-336[»]
ProteinModelPortaliQ8U3Y2.
SMRiQ8U3Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0319.

Proteomic databases

PRIDEiQ8U3Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80443; AAL80443; PF0319.
GeneIDi1468154.
KEGGipfu:PF0319.

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17245.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGYAR_PYRFU
AccessioniPrimary (citable) accession number: Q8U3Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.