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Protein

Prefoldin subunit alpha

Gene

pfdA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit alphaUniRule annotation
Alternative name(s):
GimC subunit alphaUniRule annotation
Gene namesi
Name:pfdAUniRule annotation
Ordered Locus Names:PF0375
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536831 – 146Prefoldin subunit alphaAdd BLAST146

Proteomic databases

PRIDEiQ8U3T0.

Interactioni

Subunit structurei

Heterohexamer of two alpha and four beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF0375.

Structurei

3D structure databases

ProteinModelPortaliQ8U3T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiarCOG01341. Archaea.
COG1730. LUCA.
HOGENOMiHOG000055160.
KOiK04797.
OMAiRNEFQAV.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
HAMAPiMF_00308. PfdA. 1 hit.
InterProiIPR011599. PFD_alpha_archaea.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U3T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNKELEKV AYEYQVVQAQ AQLLAQNLEL LSLAQAEVQT VKETLENLMK
60 70 80 90 100
IEDENPEILV PIGAGSFLKG KIVDKNNAII SVGSGYAVEK TLEDAIKYLD
110 120 130 140
ERIKEYDEAI RKTQEALNEL QKRAAELAKK AQEIQQKQAM SFKLKK
Length:146
Mass (Da):16,509
Last modified:June 1, 2002 - v1
Checksum:iB736A8AFD482DD96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80499.1.
RefSeqiWP_011011489.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80499; AAL80499; PF0375.
GeneIDi1468211.
KEGGipfu:PF0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80499.1.
RefSeqiWP_011011489.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U3T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0375.

Proteomic databases

PRIDEiQ8U3T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80499; AAL80499; PF0375.
GeneIDi1468211.
KEGGipfu:PF0375.

Phylogenomic databases

eggNOGiarCOG01341. Archaea.
COG1730. LUCA.
HOGENOMiHOG000055160.
KOiK04797.
OMAiRNEFQAV.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
HAMAPiMF_00308. PfdA. 1 hit.
InterProiIPR011599. PFD_alpha_archaea.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFDA_PYRFU
AccessioniPrimary (citable) accession number: Q8U3T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.