ID   EI2BL_PYRFU             Reviewed;         276 AA.
AC   Q8U3J1;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=Putative translation initiation factor eIF-2B subunit 2-like;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor;
GN   OrderedLocusNames=PF0475;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Catalyzes the exchange of initiation factor 2-bound GDP for
CC       GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of two different subunits. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AE009950; AAL80599.1; -; Genomic_DNA.
DR   RefSeq; WP_011011592.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U3J1; -.
DR   SMR; Q8U3J1; -.
DR   STRING; 186497.PF0475; -.
DR   PaxDb; 186497-PF0475; -.
DR   GeneID; 41712276; -.
DR   KEGG; pfu:PF0475; -.
DR   PATRIC; fig|186497.12.peg.499; -.
DR   eggNOG; arCOG01125; Archaea.
DR   HOGENOM; CLU_016218_2_1_2; -.
DR   OrthoDB; 45195at2157; -.
DR   PhylomeDB; Q8U3J1; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.420; translation initiation factor eif-2b, domain 1; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR027363; M1Pi_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR45860; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR45860:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Putative translation initiation factor eIF-2B
FT                   subunit 2-like"
FT                   /id="PRO_0000156108"
SQ   SEQUENCE   276 AA;  31097 MW;  B57A8C3D27A8A294 CRC64;
     MLPEKVVKIL EEMKNEKIRG ASWMAKKGAE AFILLSEELD ETSLEEGIIE LKREILEINP
     SMASLYNLAM FIPITNDREV VKLRAEEFIK RAEEAKKEIA SIGAQLIDSG DVIITHSYSS
     AVFEILKTAK RRGKQFKVIL TESAPDYEGL YLAKALQDES IEVEIITDAQ LGLFAKDATL
     AIVGADTVTK DGYVVNKAGT YLLAISCYES EVPFYVAAET YKFHQKITSK EVELVERPLY
     REGSRVRNVL FDITPWKFIR GIITELGIIL PPRDMI
//