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Q8U3J1

- EI2BL_PYRFU

UniProt

Q8U3J1 - EI2BL_PYRFU

Protein

Putative translation initiation factor eIF-2B subunit 2-like

Gene

PF0475

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of initiation factor 2-bound GDP for GTP.By similarity

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative translation initiation factor eIF-2B subunit 2-like
    Alternative name(s):
    eIF-2B GDP-GTP exchange factor
    Gene namesi
    Ordered Locus Names:PF0475
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Putative translation initiation factor eIF-2B subunit 2-likePRO_0000156108Add
    BLAST

    Proteomic databases

    PRIDEiQ8U3J1.

    Interactioni

    Subunit structurei

    Complex of two different subunits.Curated

    Protein-protein interaction databases

    STRINGi186497.PF0475.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8U3J1.
    SMRiQ8U3J1. Positions 2-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1184.
    HOGENOMiHOG000224731.
    KOiK03680.
    OMAiNPTMASL.

    Family and domain databases

    Gene3Di1.20.120.420. 1 hit.
    InterProiIPR000649. IF-2B-related.
    IPR027363. M1Pi_N.
    [Graphical view]
    PfamiPF01008. IF-2B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8U3J1-1 [UniParc]FASTAAdd to Basket

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    MLPEKVVKIL EEMKNEKIRG ASWMAKKGAE AFILLSEELD ETSLEEGIIE    50
    LKREILEINP SMASLYNLAM FIPITNDREV VKLRAEEFIK RAEEAKKEIA 100
    SIGAQLIDSG DVIITHSYSS AVFEILKTAK RRGKQFKVIL TESAPDYEGL 150
    YLAKALQDES IEVEIITDAQ LGLFAKDATL AIVGADTVTK DGYVVNKAGT 200
    YLLAISCYES EVPFYVAAET YKFHQKITSK EVELVERPLY REGSRVRNVL 250
    FDITPWKFIR GIITELGIIL PPRDMI 276
    Length:276
    Mass (Da):31,097
    Last modified:June 1, 2002 - v1
    Checksum:iB57A8C3D27A8A294
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL80599.1.
    RefSeqiNP_578204.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL80599; AAL80599; PF0475.
    GeneIDi1468316.
    KEGGipfu:PF0475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL80599.1 .
    RefSeqi NP_578204.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali Q8U3J1.
    SMRi Q8U3J1. Positions 2-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF0475.

    Proteomic databases

    PRIDEi Q8U3J1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL80599 ; AAL80599 ; PF0475 .
    GeneIDi 1468316.
    KEGGi pfu:PF0475.

    Phylogenomic databases

    eggNOGi COG1184.
    HOGENOMi HOG000224731.
    KOi K03680.
    OMAi NPTMASL.

    Family and domain databases

    Gene3Di 1.20.120.420. 1 hit.
    InterProi IPR000649. IF-2B-related.
    IPR027363. M1Pi_N.
    [Graphical view ]
    Pfami PF01008. IF-2B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiEI2BL_PYRFU
    AccessioniPrimary (citable) accession number: Q8U3J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3