Q8U3J1 (EI2BL_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative translation initiation factor eIF-2B subunit 2-like

Alternative name(s):
eIF-2B GDP-GTP exchange factor

Gene names

Ordered Locus Names:

PF0475

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus furiosus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the exchange of initiation factor 2-bound GDP for GTP By similarity.
Subunit structure	Complex of two different subunits Potential.
Sequence similarities	Belongs to the eIF-2B alpha/beta/delta subunits family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Putative translation initiation factor eIF-2B subunit 2-like		PRO_0000156108

Sequences

	Sequence		Length	Mass (Da)
	Q8U3J1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B57A8C3D27A8A294	FASTA	276	31,097
	10 20 30 40 50 60 MLPEKVVKIL EEMKNEKIRG ASWMAKKGAE AFILLSEELD ETSLEEGIIE LKREILEINP 70 80 90 100 110 120 SMASLYNLAM FIPITNDREV VKLRAEEFIK RAEEAKKEIA SIGAQLIDSG DVIITHSYSS 130 140 150 160 170 180 AVFEILKTAK RRGKQFKVIL TESAPDYEGL YLAKALQDES IEVEIITDAQ LGLFAKDATL 190 200 210 220 230 240 AIVGADTVTK DGYVVNKAGT YLLAISCYES EVPFYVAAET YKFHQKITSK EVELVERPLY 250 260 270 REGSRVRNVL FDITPWKFIR GIITELGIIL PPRDMI

References

[1]

"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL80599.1.
RefSeq	NP_578204.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U3J1.
SMR	Q8U3J1. Positions 2-275.
ModBase	Search...
Protein-protein interaction databases
STRING	186497.PF0475.
Proteomic databases
PRIDE	Q8U3J1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL80599; AAL80599; PF0475.
GeneID	1468316.
KEGG	pfu:PF0475.
Phylogenomic databases
eggNOG	COG1184.
HOGENOM	HOG000224731.
KO	K03680.
OMA	VFENEFR.
ProtClustDB	PRK08335.
Family and domain databases
InterPro	IPR000649. IF-2B-related. [Graphical view]
PANTHER	PTHR10233. PTHR10233. 1 hit.
Pfam	PF01008. IF-2B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EI2BL_PYRFU

Accession

Primary (citable) accession number: Q8U3J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program