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Q8U3J1 (EI2BL_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative translation initiation factor eIF-2B subunit 2-like
Alternative name(s):
eIF-2B GDP-GTP exchange factor
Gene names
Ordered Locus Names:PF0475
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the exchange of initiation factor 2-bound GDP for GTP By similarity.

Subunit structure

Complex of two different subunits Potential.

Sequence similarities

Belongs to the eIF-2B alpha/beta/delta subunits family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Putative translation initiation factor eIF-2B subunit 2-like
PRO_0000156108

Sequences

Sequence LengthMass (Da)Tools
Q8U3J1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B57A8C3D27A8A294

FASTA27631,097
        10         20         30         40         50         60 
MLPEKVVKIL EEMKNEKIRG ASWMAKKGAE AFILLSEELD ETSLEEGIIE LKREILEINP 

        70         80         90        100        110        120 
SMASLYNLAM FIPITNDREV VKLRAEEFIK RAEEAKKEIA SIGAQLIDSG DVIITHSYSS 

       130        140        150        160        170        180 
AVFEILKTAK RRGKQFKVIL TESAPDYEGL YLAKALQDES IEVEIITDAQ LGLFAKDATL 

       190        200        210        220        230        240 
AIVGADTVTK DGYVVNKAGT YLLAISCYES EVPFYVAAET YKFHQKITSK EVELVERPLY 

       250        260        270 
REGSRVRNVL FDITPWKFIR GIITELGIIL PPRDMI 

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL80599.1.
RefSeqNP_578204.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8U3J1.
SMRQ8U3J1. Positions 2-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF0475.

Proteomic databases

PRIDEQ8U3J1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL80599; AAL80599; PF0475.
GeneID1468316.
KEGGpfu:PF0475.

Phylogenomic databases

eggNOGCOG1184.
HOGENOMHOG000224731.
KOK03680.
OMANPTMASL.

Family and domain databases

Gene3D1.20.120.420. 1 hit.
InterProIPR000649. IF-2B-related.
IPR027363. M1Pi_N.
[Graphical view]
PfamPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEI2BL_PYRFU
AccessionPrimary (citable) accession number: Q8U3J1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries