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Protein

Putative translation initiation factor eIF-2B subunit 2-like

Gene

PF0475

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the exchange of initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Putative translation initiation factor eIF-2B subunit 2-like
Alternative name(s):
eIF-2B GDP-GTP exchange factor
Gene namesi
Ordered Locus Names:PF0475
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Putative translation initiation factor eIF-2B subunit 2-likePRO_0000156108Add
BLAST

Proteomic databases

PRIDEiQ8U3J1.

Interactioni

Subunit structurei

Complex of two different subunits.Curated

Protein-protein interaction databases

STRINGi186497.PF0475.

Structurei

3D structure databases

ProteinModelPortaliQ8U3J1.
SMRiQ8U3J1. Positions 2-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1184.
HOGENOMiHOG000224731.
KOiK03680.
OMAiVFENEFR.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U3J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPEKVVKIL EEMKNEKIRG ASWMAKKGAE AFILLSEELD ETSLEEGIIE
60 70 80 90 100
LKREILEINP SMASLYNLAM FIPITNDREV VKLRAEEFIK RAEEAKKEIA
110 120 130 140 150
SIGAQLIDSG DVIITHSYSS AVFEILKTAK RRGKQFKVIL TESAPDYEGL
160 170 180 190 200
YLAKALQDES IEVEIITDAQ LGLFAKDATL AIVGADTVTK DGYVVNKAGT
210 220 230 240 250
YLLAISCYES EVPFYVAAET YKFHQKITSK EVELVERPLY REGSRVRNVL
260 270
FDITPWKFIR GIITELGIIL PPRDMI
Length:276
Mass (Da):31,097
Last modified:June 1, 2002 - v1
Checksum:iB57A8C3D27A8A294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80599.1.
RefSeqiNP_578204.1. NC_003413.1.
WP_011011592.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80599; AAL80599; PF0475.
GeneIDi1468316.
KEGGipfu:PF0475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80599.1.
RefSeqiNP_578204.1. NC_003413.1.
WP_011011592.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U3J1.
SMRiQ8U3J1. Positions 2-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0475.

Proteomic databases

PRIDEiQ8U3J1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80599; AAL80599; PF0475.
GeneIDi1468316.
KEGGipfu:PF0475.

Phylogenomic databases

eggNOGiCOG1184.
HOGENOMiHOG000224731.
KOiK03680.
OMAiVFENEFR.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiEI2BL_PYRFU
AccessioniPrimary (citable) accession number: Q8U3J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2002
Last modified: May 27, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.