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Protein
Submitted name:

Uncharacterized protein

Gene

PF0537

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi558 – 5581ManganeseCombined sources
Metal bindingi628 – 6281ManganeseCombined sources
Metal bindingi745 – 7451Manganese; via pros nitrogenCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:PF0537Imported
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ8U3D2.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U04X-ray2.25A1-770[»]
1Z25X-ray2.70A1-770[»]
1Z26X-ray2.50A1-770[»]
ProteinModelPortaliQ8U3D2.
SMRiQ8U3D2. Positions 1-770.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U3D2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini473 – 756284PiwiInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiarCOG03890. Archaea.
COG1431. LUCA.
KOiK07578.
OMAiIEVISIR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
IPR021103. siRNA-bd_Argonaute.
[Graphical view]
PfamiPF12212. PAZ_siRNAbind. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50822. PIWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U3D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKVVINLV KINKKIIPDK IYVYRLFNDP EEELQKEGYS IYRLAYENVG
60 70 80 90 100
IVIDPENLII ATTKELEYEG EFIPEGEISF SELRNDYQSK LVLRLLKENG
110 120 130 140 150
IGEYELSKLL RKFRKPKTFG DYKVIPSVEM SVIKHDEDFY LVIHIIHQIQ
160 170 180 190 200
SMKTLWELVN KDPKELEEFL MTHKENLMLK DIASPLKTVY KPCFEEYTKK
210 220 230 240 250
PKLDHNQEIV KYWYNYHIER YWNTPEAKLE FYRKFGQVDL KQPAILAKFA
260 270 280 290 300
SKIKKNKNYK IYLLPQLVVP TYNAEQLESD VAKEILEYTK LMPEERKELL
310 320 330 340 350
ENILAEVDSD IIDKSLSEIE VEKIAQELEN KIRVRDDKGN SVPISQLNVQ
360 370 380 390 400
KSQLLLWTNY SRKYPVILPY EVPEKFRKIR EIPMFIILDS GLLADIQNFA
410 420 430 440 450
TNEFRELVKS MYYSLAKKYN SLAKKARSTN EIGLPFLDFR GKEKVITEDL
460 470 480 490 500
NSDKGIIEVV EQVSSFMKGK ELGLAFIAAR NKLSSEKFEE IKRRLFNLNV
510 520 530 540 550
ISQVVNEDTL KNKRDKYDRN RLDLFVRHNL LFQVLSKLGV KYYVLDYRFN
560 570 580 590 600
YDYIIGIDVA PMKRSEGYIG GSAVMFDSQG YIRKIVPIKI GEQRGESVDM
610 620 630 640 650
NEFFKEMVDK FKEFNIKLDN KKILLLRDGR ITNNEEEGLK YISEMFDIEV
660 670 680 690 700
VTMDVIKNHP VRAFANMKMY FNLGGAIYLI PHKLKQAKGT PIPIKLAKKR
710 720 730 740 750
IIKNGKVEKQ SITRQDVLDI FILTRLNYGS ISADMRLPAP VHYAHKFANA
760 770
IRNEWKIKEE FLAEGFLYFV
Length:770
Mass (Da):90,390
Last modified:June 1, 2002 - v1
Checksum:iE68D7618C3FC7D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80661.1.
RefSeqiWP_011011654.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80661; AAL80661; PF0537.
GeneIDi1468378.
KEGGipfu:PF0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80661.1.
RefSeqiWP_011011654.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U04X-ray2.25A1-770[»]
1Z25X-ray2.70A1-770[»]
1Z26X-ray2.50A1-770[»]
ProteinModelPortaliQ8U3D2.
SMRiQ8U3D2. Positions 1-770.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8U3D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80661; AAL80661; PF0537.
GeneIDi1468378.
KEGGipfu:PF0537.

Phylogenomic databases

eggNOGiarCOG03890. Archaea.
COG1431. LUCA.
KOiK07578.
OMAiIEVISIR.

Miscellaneous databases

EvolutionaryTraceiQ8U3D2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
IPR021103. siRNA-bd_Argonaute.
[Graphical view]
PfamiPF12212. PAZ_siRNAbind. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50822. PIWI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1Imported.
  2. "Crystal structure of Argonaute and its implications for RISC slicer activity."
    Song J.J., Smith S.K., Hannon G.J., Joshua-Tor L.
    Science 305:1434-1437(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH MANGANESE.

Entry informationi

Entry nameiQ8U3D2_PYRFU
AccessioniPrimary (citable) accession number: Q8U3D2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.