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Q8U381 (MPGP_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannosyl-3-phosphoglycerate phosphatase
Short name=MPGP
EC=3.1.3.70
Gene names
Name:mngB
Ordered Locus Names:PF0590
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) By similarity. HAMAP MF_00617

Catalytic activity

2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. HAMAP MF_00617

Pathway

Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2. HAMAP MF_00617

Subcellular location

Cytoplasm By similarity HAMAP MF_00617.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. MPGP family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmannosylglycerate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmannosyl-3-phosphoglycerate phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Mannosyl-3-phosphoglycerate phosphatase HAMAP MF_00617
PRO_0000184972

Sequences

Sequence LengthMass (Da)Tools
Q8U381 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 133DE5E84FB0AC02

FASTA24228,022
        10         20         30         40         50         60 
MIRVIFLDLD KTLLPEYDPE PAIPIVEELK KKGFEIVFNS SKTRAEQEYY REKLNVKGPF 

        70         80         90        100        110        120 
IVENGSAIYI PSNYFPFEVP GVKRGEYMVL ELGVKVEEIR KALKELEAEY GLKYYGNSTD 

       130        140        150        160        170        180 
EEIEKFTKLP KHLIPLAKDR EYSETIFLWK REGWEKDLIR KGFKVTMGSR FYAVHGNSDK 

       190        200        210        220        230        240 
GKAAKLLLDL YKRVDEVESY AVGDGENDFP MFDVVDFAFL IGDLRHENAE NVTSIKDVLK 


KI

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009950 Genomic DNA. Translation: AAL80714.1.
RefSeqNP_578319.2. NC_003413.1.

3D structure databases

ProteinModelPortalQ8U381.
SMRQ8U381. Positions 1-242.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000004212; EBPYRP00000004073; EBPYRG00000004212.
GeneID1468433.
GenomeReviewsGene locus PF0590 in contig AE009950_GR.
KEGGpfu:PF0590.
NMPDRfig|186497.1.peg.604.

Phylogenomic databases

GeneTreeEBGT00050000023295.
HOGENOMHBG635303.
OMAEYSETIF.
PhylomeDBQ8U381.
ProtClustDBPRK00192.

Family and domain databases

HAMAPMF_00617. MPGP_rel.
[Tree]
InterProIPR023214. HAD-like_dom.
IPR013200. HAD-SF_hydro-like_3.
IPR006379. HAD-SF_hydro_IIB.
IPR006381. HAD-SF_hydro_IIB_YedP.
IPR012815. MPG_Pase.
IPR012813. Osmo_MPG_phos.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK07026.
PfamPF08282. Hydrolase_3. 2 hits.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
TIGR01486. HAD-SF-IIB-MPGP. 1 hit.
TIGR02461. Osmo_MPG_phos. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPGP_PYRFU
AccessionPrimary (citable) accession number: Q8U381
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2002
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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