Reviewed, UniProtKB/Swiss-Prot Q8U381 (MPGP_PYRFU)

Names and origin

Protein names

Recommended name:
    Mannosyl-3-phosphoglycerate phosphatase
      Short name=MPGP
    EC=3.1.3.70

Gene names

Name:	mngB
Ordered Locus Names:	PF0590

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) By similarity.
Catalytic activity	2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. HAMAP MF_00617
Pathway	Carbohydrate biosynthesis; mannosylglycerate biosynthesis; 2(alpha-D-mannosyl)-D-glycerate from GDP-D-mannose (MPG route): step 2/2. HAMAP MF_00617
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. MPGP family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mannosylglycerate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannosyl-3-phosphoglycerate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Mannosyl-3-phosphoglycerate phosphatase HAMAP MF_00617		PRO_0000184972

Sequences

	Sequence		Length	Mass (Da)
	Q8U381-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 133DE5E84FB0AC02	FASTA	242	28,022
	10 20 30 40 50 60 MIRVIFLDLD KTLLPEYDPE PAIPIVEELK KKGFEIVFNS SKTRAEQEYY REKLNVKGPF 70 80 90 100 110 120 IVENGSAIYI PSNYFPFEVP GVKRGEYMVL ELGVKVEEIR KALKELEAEY GLKYYGNSTD 130 140 150 160 170 180 EEIEKFTKLP KHLIPLAKDR EYSETIFLWK REGWEKDLIR KGFKVTMGSR FYAVHGNSDK 190 200 210 220 230 240 GKAAKLLLDL YKRVDEVESY AVGDGENDFP MFDVVDFAFL IGDLRHENAE NVTSIKDVLK KI

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010181 Genomic DNA. Translation: AAL80714.1.
RefSeq	NP_578319.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1468433.
GenomeReviews	Gene locus PF0590 in contig AE009950_GR.
KEGG	pfu:PF0590.
NMPDR	fig|186497.1.peg.604.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8U381.
OMA	Q8U381. EYSETIF.
Enzyme and pathway databases
BRENDA	3.1.3.70. 321.
Family and domain databases
HAMAP	MF_00617. [Tree]
InterPro	IPR013200. HAD-SF_hydro-like_3. IPR006379. HAD-SF_hydro_IIB. IPR006381. HAD-SF_hydro_IIB_YedP. IPR012813. Osmo_MPG_phos. [Graphical view]
Pfam	PF08282. Hydrolase_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit. TIGR01486. HAD-SF-IIB-MPGP. 1 hit. TIGR02461. osmo_MPG_phos. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPGP_PYRFU

Accession

Primary (citable) accession number: Q8U381

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)