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Q8U380 (MPGS_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannosyl-3-phosphoglycerate synthase
Short name=MPG synthase
Short name=MPGS
EC=2.4.1.217
Gene names
Name:mngA
Ordered Locus Names:PF0591
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG) By similarity.

Catalytic activity

GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate.

Pathway

Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 1/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glycosyltransferase 2 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmannosylglycerate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmannosyl-3-phosphoglycerate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Mannosyl-3-phosphoglycerate synthase
PRO_0000059286

Sequences

Sequence LengthMass (Da)Tools
Q8U380 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 259598FEE665ED25

FASTA39445,426
        10         20         30         40         50         60 
MLLEAPVYKE IFGAVKIYEL QKVIKLDTET EDVPVYTITN IPREKIYDTL GKMAVIVPMK 

        70         80         90        100        110        120 
NEKLHLVDGV LKAIPHKCPI IIVSNSKREG PNRYRLEVDL VRHFYNLTNS KIIMVHQRDP 

       130        140        150        160        170        180 
GLAKAFQKVG YTDILDEKGN IRSGKGEGML IGILLAKAIG AEYVGFVDAD NYIPGAVNEY 

       190        200        210        220        230        240 
VKDYAAGFLM SESDYTMVRL HWRHKPKVTK GTLYFKKWGR VSEITNHYLN MLISEQTSFE 

       250        260        270        280        290        300 
TTIMVTGNAG EHAMTMKLAE IMPFSTNYSI EPYEIVYLLE RFGKWENVEE FKDVFDQGIE 

       310        320        330        340        350        360 
IFQIETLNPH FHEDKGQEHV REMILLSLAT IYHSKMASKN LKRRILNDLI EHGILKEGEE 

       370        380        390 
PPKLRIMRPI NEIDIEEWMK VVENNSETLL RFGL

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009950 Genomic DNA. Translation: AAL80715.1.
RefSeqNP_578320.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8U380.
ModBaseSearch...

Protein family/group databases

CAZyGT55. Glycosyltransferase Family 55.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000005050; EBPYRP00000004911; EBPYRG00000005049.
GeneID1468434.
GenomeReviewsGene locus PF0591 in contig AE009950_GR.
KEGGpfu:PF0591.
NMPDRfig|186497.1.peg.605.

Phylogenomic databases

GeneTreeEBGT00050000022714.
HOGENOMHBG297698.
OMARVSEITN.
ProtClustDBPRK14503.

Family and domain databases

InterProIPR012812. Osmo_MPG_synth.
[Graphical view]
KOK05947.
PfamPF09488. Osmo_MPGsynth. 1 hit.
[Graphical view]
TIGRFAMsTIGR02460. Osmo_MPGsynth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPGS_PYRFU
AccessionPrimary (citable) accession number: Q8U380
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2002
Last modified: November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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