Reviewed, UniProtKB/Swiss-Prot Q8U380 (MPGS_PYRFU)

Names and origin

Protein names

Recommended name:
    Mannosyl-3-phosphoglycerate synthase
      Short name=MPG synthase
      Short name=MPGS
    EC=2.4.1.217

Gene names

Name:	mngA
Ordered Locus Names:	PF0591

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG) By similarity.
Catalytic activity	GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate.
Pathway	Carbohydrate biosynthesis; mannosylglycerate biosynthesis; 2(alpha-D-mannosyl)-D-glycerate from GDP-D-mannose (MPG route): step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyltransferase 2 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mannosylglycerate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannosyl-3-phosphoglycerate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannosyl-3-phosphoglycerate synthase		PRO_0000059286

Sequences

	Sequence		Length	Mass (Da)
	Q8U380-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 259598FEE665ED25	FASTA	394	45,426
	10 20 30 40 50 60 MLLEAPVYKE IFGAVKIYEL QKVIKLDTET EDVPVYTITN IPREKIYDTL GKMAVIVPMK 70 80 90 100 110 120 NEKLHLVDGV LKAIPHKCPI IIVSNSKREG PNRYRLEVDL VRHFYNLTNS KIIMVHQRDP 130 140 150 160 170 180 GLAKAFQKVG YTDILDEKGN IRSGKGEGML IGILLAKAIG AEYVGFVDAD NYIPGAVNEY 190 200 210 220 230 240 VKDYAAGFLM SESDYTMVRL HWRHKPKVTK GTLYFKKWGR VSEITNHYLN MLISEQTSFE 250 260 270 280 290 300 TTIMVTGNAG EHAMTMKLAE IMPFSTNYSI EPYEIVYLLE RFGKWENVEE FKDVFDQGIE 310 320 330 340 350 360 IFQIETLNPH FHEDKGQEHV REMILLSLAT IYHSKMASKN LKRRILNDLI EHGILKEGEE 370 380 390 PPKLRIMRPI NEIDIEEWMK VVENNSETLL RFGL

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010181 Genomic DNA. Translation: AAL80715.1.
RefSeq	NP_578320.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT55. Glycosyltransferase Family 55.
Genome annotation databases
GeneID	1468434.
GenomeReviews	Gene locus PF0591 in contig AE009950_GR.
KEGG	pfu:PF0591.
NMPDR	fig|186497.1.peg.605.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8U380.
OMA	Q8U380. EIFQIET.
Enzyme and pathway databases
BRENDA	2.4.1.217. 321.
Family and domain databases
InterPro	IPR012812. Osmo_MPG_synth. [Graphical view]
Pfam	PF09488. Osmo_MPGsynth. 1 hit. [Graphical view]
TIGRFAMs	TIGR02460. osmo_MPGsynth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPGS_PYRFU

Accession

Primary (citable) accession number: Q8U380

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)