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Q8U2E6

- SYL_PYRFU

UniProt

Q8U2E6 - SYL_PYRFU

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Protein
Leucine--tRNA ligase
Gene
leuS, PF0890
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PF0890
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Leucine--tRNA ligaseUniRule annotation
PRO_0000152139Add
BLAST

Proteomic databases

PRIDEiQ8U2E6.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0890.

Structurei

3D structure databases

ProteinModelPortaliQ8U2E6.
SMRiQ8U2E6. Positions 4-967.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi650 – 6545"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U2E6-1 [UniParc]FASTAAdd to Basket

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MPELNFKAIE EKWQKRWLEA KIFEPNIKDK PKEKKFYITV AFPYLSGHLH    50
VGHARTYTIP DVIARFKRMQ GYNVLFPMAW HITGSPIVGI AERIKNRDPQ 100
TIWIYRDVYK VPEDILWTFE DPVNIVKYFM KAAKETFIRA GFSVDWSREF 150
YTTSLFPPFS KFIEWQFWKL KEKGYIVKGT HRVRWDPVVG TPLGDHDLMD 200
GEDVPILEYI LIKFELKEGE ETVYLPAATL RPETVYGVTN MWLNPEATYV 250
KAKVKKGDKV ETWIISKEAA YKLSFQDREI EVVEEFKGEK LIGKFVRNPV 300
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK KQTDILLKYD 350
IDPRIVENIT YISLIKLEGY GEFPAVEEVQ KLGVKSQKDK DKLEQATKTI 400
YRAEYHKGIF KIPPYEGKPV SEVKELIAKD LMEKGIGEIM YEFAEKNVIS 450
RFGNRAVIKI IHDQWFIDYG NPEWKEKARE ALKRMKILPE SRRAQFEAII 500
EWLDKKACAR KVGLGTPLPW DPDWVIESLS DSTIYMAYYT ISRHINKLRE 550
EGKLDPEKLT PEFFDYIFLE EFDEKKEKEL EEKTGISAEI IHEMKEEFEY 600
WYPLDWRCSA KDLIPNHLTF FIFNHVAIFP EKHWPKGIAV NGFGTLEGQK 650
MSKSKGNVLN FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGRLRKQ 700
IERFYELISQ FAEYEARENV ELKDIDKWML HRLNKAIKGT TDALEEFRTR 750
TAVQWAFYTI MNDLRWYLRR TEGRDDEAKR YVLRTLADIW VRLMAPFTPH 800
ICEELWEKLG GEGFVSLAKW PDPVEEWWNE TIEAEEEYVK SVMEDIKEII 850
EVAKIENARR AYIYTAEDWK WKVVEVVAEK RDFKAAMSEL MKDQELRKRG 900
KEIAKIVERL IKDRAFEVKR IDEEKVLREA KDFIEKELGI EIIINPSEDK 950
GGKKKQAMPL KPAIFIE 967
Length:967
Mass (Da):113,720
Last modified:June 1, 2002 - v1
Checksum:iADABF8E6A4FAD7E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL81014.1.
RefSeqiNP_578619.1. NC_003413.1.
WP_011012025.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81014; AAL81014; PF0890.
GeneIDi1468752.
KEGGipfu:PF0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL81014.1 .
RefSeqi NP_578619.1. NC_003413.1.
WP_011012025.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8U2E6.
SMRi Q8U2E6. Positions 4-967.
ModBasei Search...

Protein-protein interaction databases

STRINGi 186497.PF0890.

Proteomic databases

PRIDEi Q8U2E6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL81014 ; AAL81014 ; PF0890 .
GeneIDi 1468752.
KEGGi pfu:PF0890.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiSYL_PYRFU
AccessioniPrimary (citable) accession number: Q8U2E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi