Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8U2E6

- SYL_PYRFU

UniProt

Q8U2E6 - SYL_PYRFU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei653 – 6531ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PF0890
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 967967Leucine--tRNA ligasePRO_0000152139Add
    BLAST

    Proteomic databases

    PRIDEiQ8U2E6.

    Interactioni

    Protein-protein interaction databases

    STRINGi186497.PF0890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8U2E6.
    SMRiQ8U2E6. Positions 4-967.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi650 – 6545"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8U2E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPELNFKAIE EKWQKRWLEA KIFEPNIKDK PKEKKFYITV AFPYLSGHLH    50
    VGHARTYTIP DVIARFKRMQ GYNVLFPMAW HITGSPIVGI AERIKNRDPQ 100
    TIWIYRDVYK VPEDILWTFE DPVNIVKYFM KAAKETFIRA GFSVDWSREF 150
    YTTSLFPPFS KFIEWQFWKL KEKGYIVKGT HRVRWDPVVG TPLGDHDLMD 200
    GEDVPILEYI LIKFELKEGE ETVYLPAATL RPETVYGVTN MWLNPEATYV 250
    KAKVKKGDKV ETWIISKEAA YKLSFQDREI EVVEEFKGEK LIGKFVRNPV 300
    TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK KQTDILLKYD 350
    IDPRIVENIT YISLIKLEGY GEFPAVEEVQ KLGVKSQKDK DKLEQATKTI 400
    YRAEYHKGIF KIPPYEGKPV SEVKELIAKD LMEKGIGEIM YEFAEKNVIS 450
    RFGNRAVIKI IHDQWFIDYG NPEWKEKARE ALKRMKILPE SRRAQFEAII 500
    EWLDKKACAR KVGLGTPLPW DPDWVIESLS DSTIYMAYYT ISRHINKLRE 550
    EGKLDPEKLT PEFFDYIFLE EFDEKKEKEL EEKTGISAEI IHEMKEEFEY 600
    WYPLDWRCSA KDLIPNHLTF FIFNHVAIFP EKHWPKGIAV NGFGTLEGQK 650
    MSKSKGNVLN FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGRLRKQ 700
    IERFYELISQ FAEYEARENV ELKDIDKWML HRLNKAIKGT TDALEEFRTR 750
    TAVQWAFYTI MNDLRWYLRR TEGRDDEAKR YVLRTLADIW VRLMAPFTPH 800
    ICEELWEKLG GEGFVSLAKW PDPVEEWWNE TIEAEEEYVK SVMEDIKEII 850
    EVAKIENARR AYIYTAEDWK WKVVEVVAEK RDFKAAMSEL MKDQELRKRG 900
    KEIAKIVERL IKDRAFEVKR IDEEKVLREA KDFIEKELGI EIIINPSEDK 950
    GGKKKQAMPL KPAIFIE 967
    Length:967
    Mass (Da):113,720
    Last modified:June 1, 2002 - v1
    Checksum:iADABF8E6A4FAD7E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81014.1.
    RefSeqiNP_578619.1. NC_003413.1.
    WP_011012025.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81014; AAL81014; PF0890.
    GeneIDi1468752.
    KEGGipfu:PF0890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81014.1 .
    RefSeqi NP_578619.1. NC_003413.1.
    WP_011012025.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali Q8U2E6.
    SMRi Q8U2E6. Positions 4-967.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF0890.

    Proteomic databases

    PRIDEi Q8U2E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81014 ; AAL81014 ; PF0890 .
    GeneIDi 1468752.
    KEGGi pfu:PF0890.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiSYL_PYRFU
    AccessioniPrimary (citable) accession number: Q8U2E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3