Reviewed,
UniProtKB/Swiss-Prot Q8U262 (RIFK_PYRFU)
Last modified
February 9, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Riboflavin kinase Short name=RFK EC=2.7.1.161 Alternative name(s): CTP:riboflavin 5'-phosphotransferase CTP-dependent riboflavin kinase Flavokinase | ||||
| Gene names |
| ||||
| Organism | Pyrococcus furiosus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2261 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 212 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) By similarity. HAMAP MF_01285 |
| Catalytic activity | CTP + riboflavin = CDP + FMN. HAMAP MF_01285 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01285 |
| Pathway | Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1. HAMAP MF_01285 |
| Sequence similarities | Belongs to the archaeal riboflavin kinase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | FMN biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependentInferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | magnesium ion binding Inferred from electronic annotation. Source: HAMAP nucleotide bindingInferred from electronic annotation. Source: HAMAP riboflavin kinase activityInferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 212 | 212 | Riboflavin kinase HAMAP MF_01285 | PRO_0000322102 | |||||
Regions | |||||||||
| Nucleotide binding | 97 – 102 | 6 | CDP By similarity | ||||||
| Nucleotide binding | 193 – 196 | 4 | CDP By similarity | ||||||
| Region | 1 – 87 | 87 | H-T-H motif-like HAMAP MF_01285 | ||||||
| Region | 88 – 212 | 125 | Riboflavin kinase HAMAP MF_01285 | ||||||
Sites | |||||||||
| Metal binding | 124 | 1 | Magnesium By similarity | ||||||
| Metal binding | 126 | 1 | Magnesium By similarity | ||||||
| Binding site | 180 | 1 | FMN By similarity | ||||||
| Binding site | 188 | 1 | FMN By similarity | ||||||
Sequences
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References
| [1] | "The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE009950 Genomic DNA. Translation: AAL81112.1. |
| RefSeq | NP_578717.1. |
3D structure databases | |
| SMR | Q8U262. Positions 11-199. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1468853. |
| GenomeReviews | Gene locus PF0988 in contig AE009950_GR. |
| KEGG | pfu:PF0988. |
| NMPDR | fig|186497.1.peg.1024. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG553349. |
| OMA | GAYYVRQ. |
Family and domain databases | |
| HAMAP | MF_01285. Riboflavin_kinase. Fused. [Tree] |
| InterPro | IPR000835. HTH_MarR. IPR002834. Riboflavin_kinase_arc. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF01982. CTP-dep_RFKase. 1 hit. PF01047. MarR. 1 hit. [Graphical view] |
| PROSITE | PS50995. HTH_MARR_2. 1 hit. Uncertain. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIFK_PYRFU | ||||||||
| Accession | Primary (citable) accession number: Q8U262 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


