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Q8U260

- SYFB_PYRFU

UniProt

Q8U260 - SYFB_PYRFU

Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
    Short name:
    PheRSUniRule annotation
    Gene namesi
    Name:pheTUniRule annotation
    Ordered Locus Names:PF0990
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Phenylalanine--tRNA ligase beta subunitPRO_0000127008Add
    BLAST

    Proteomic databases

    PRIDEiQ8U260.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotation

    Protein-protein interaction databases

    IntActiQ8U260. 1 interaction.
    STRINGi186497.PF0990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8U260.
    SMRiQ8U260. Positions 2-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini278 – 35477B5UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.UniRule annotation
    Contains 1 B5 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0072.
    HOGENOMiHOG000105094.
    KOiK01890.
    OMAiNTHRSYP.

    Family and domain databases

    Gene3Di3.30.56.20. 1 hit.
    HAMAPiMF_00284. Phe_tRNA_synth_beta2.
    InterProiIPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR004531. Phe-tRNA-synth_IIc_bsu_arc.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR022918. Phe_tRNA_ligase_beta2_bac/arc.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view]
    PfamiPF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SMARTiSM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 2 hits.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsiTIGR00471. pheT_arch. 1 hit.
    PROSITEiPS51483. B5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8U260-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKFDVAKSD LERLVGREFS VEEWEDLVLY AKCELDDVWE EDGKIYFKLD    50
    SKDTNRPDLW SAEGVARQIR WALGLAKGLP KYEVEESDVV VYVDKKLRNI 100
    RPYGVYAVVE GLKLDEEALS QLIQLQEKVA LTYGRRRREV AIGIFDFDKV 150
    KPPIYYRAAE KTEKFVPLGY SEEMTLEEIL EKHEKGREYG HLIRDKPYYP 200
    LLVDSEGNVL SMPPIINSEL TGRVTTETKN VFVDVTGWDL RKVMLALNVI 250
    VTALAERGGK IKRVKVIYPD FEITTPDLTP KEFEVSFEYI RKLSGLELSN 300
    EEIKELLERM MYEVEILSEN KAKVKYPAFR DDIMHTRDVL EDVLIAYGYN 350
    NIDPEEPKLA VQGRGDPFKD FEDAIRDLMV GFGLQEVMTF NLTSKEVQFD 400
    KMNIPEEEIV EIANPISSRW SALRKWLLPS LMEFLSNNTH EEYPQRIFEV 450
    GLATLIDESR ETKTVSEPKL AVALAGSGYT FTNAKEILDS LMRHLGIEYD 500
    IEETVHGSFI PGRVGKILVD GKEIGIIGEI HPQVLENWNI QVPVVAFEIF 550
    LKPLYR 556
    Length:556
    Mass (Da):63,963
    Last modified:June 1, 2002 - v1
    Checksum:iCFFB32F60D001432
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81114.1.
    RefSeqiNP_578719.1. NC_003413.1.
    WP_011012127.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81114; AAL81114; PF0990.
    GeneIDi1468855.
    KEGGipfu:PF0990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81114.1 .
    RefSeqi NP_578719.1. NC_003413.1.
    WP_011012127.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali Q8U260.
    SMRi Q8U260. Positions 2-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8U260. 1 interaction.
    STRINGi 186497.PF0990.

    Proteomic databases

    PRIDEi Q8U260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81114 ; AAL81114 ; PF0990 .
    GeneIDi 1468855.
    KEGGi pfu:PF0990.

    Phylogenomic databases

    eggNOGi COG0072.
    HOGENOMi HOG000105094.
    KOi K01890.
    OMAi NTHRSYP.

    Family and domain databases

    Gene3Di 3.30.56.20. 1 hit.
    HAMAPi MF_00284. Phe_tRNA_synth_beta2.
    InterProi IPR005146. B3/B4_tRNA-bd.
    IPR009061. DNA-bd_dom_put.
    IPR004531. Phe-tRNA-synth_IIc_bsu_arc.
    IPR020825. Phe-tRNA_synthase_B3/B4.
    IPR022918. Phe_tRNA_ligase_beta2_bac/arc.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR005147. tRNA_synthase_B5-dom.
    [Graphical view ]
    Pfami PF03483. B3_4. 1 hit.
    PF03484. B5. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SMARTi SM00873. B3_4. 1 hit.
    SM00874. B5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 2 hits.
    SSF56037. SSF56037. 1 hit.
    TIGRFAMsi TIGR00471. pheT_arch. 1 hit.
    PROSITEi PS51483. B5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiSYFB_PYRFU
    AccessioniPrimary (citable) accession number: Q8U260
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3