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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheTUniRule annotation
Ordered Locus Names:PF0990
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Phenylalanine--tRNA ligase beta subunitPRO_0000127008Add
BLAST

Proteomic databases

PRIDEiQ8U260.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ8U260. 1 interaction.
STRINGi186497.PF0990.

Structurei

3D structure databases

ProteinModelPortaliQ8U260.
SMRiQ8U260. Positions 2-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 35477B5UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.UniRule annotation
Contains 1 B5 domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0072.
HOGENOMiHOG000105094.
KOiK01890.
OMAiFPMMGVE.

Family and domain databases

Gene3Di3.30.56.20. 1 hit.
HAMAPiMF_00284. Phe_tRNA_synth_beta2.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR004531. Phe-tRNA-synth_IIc_bsu_arc.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR022918. Phe_tRNA_ligase_beta2_bac/arc.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 2 hits.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00471. pheT_arch. 1 hit.
PROSITEiPS51483. B5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFDVAKSD LERLVGREFS VEEWEDLVLY AKCELDDVWE EDGKIYFKLD
60 70 80 90 100
SKDTNRPDLW SAEGVARQIR WALGLAKGLP KYEVEESDVV VYVDKKLRNI
110 120 130 140 150
RPYGVYAVVE GLKLDEEALS QLIQLQEKVA LTYGRRRREV AIGIFDFDKV
160 170 180 190 200
KPPIYYRAAE KTEKFVPLGY SEEMTLEEIL EKHEKGREYG HLIRDKPYYP
210 220 230 240 250
LLVDSEGNVL SMPPIINSEL TGRVTTETKN VFVDVTGWDL RKVMLALNVI
260 270 280 290 300
VTALAERGGK IKRVKVIYPD FEITTPDLTP KEFEVSFEYI RKLSGLELSN
310 320 330 340 350
EEIKELLERM MYEVEILSEN KAKVKYPAFR DDIMHTRDVL EDVLIAYGYN
360 370 380 390 400
NIDPEEPKLA VQGRGDPFKD FEDAIRDLMV GFGLQEVMTF NLTSKEVQFD
410 420 430 440 450
KMNIPEEEIV EIANPISSRW SALRKWLLPS LMEFLSNNTH EEYPQRIFEV
460 470 480 490 500
GLATLIDESR ETKTVSEPKL AVALAGSGYT FTNAKEILDS LMRHLGIEYD
510 520 530 540 550
IEETVHGSFI PGRVGKILVD GKEIGIIGEI HPQVLENWNI QVPVVAFEIF

LKPLYR
Length:556
Mass (Da):63,963
Last modified:June 1, 2002 - v1
Checksum:iCFFB32F60D001432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81114.1.
RefSeqiNP_578719.1. NC_003413.1.
WP_011012127.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81114; AAL81114; PF0990.
GeneIDi1468855.
KEGGipfu:PF0990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81114.1.
RefSeqiNP_578719.1. NC_003413.1.
WP_011012127.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U260.
SMRiQ8U260. Positions 2-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8U260. 1 interaction.
STRINGi186497.PF0990.

Proteomic databases

PRIDEiQ8U260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81114; AAL81114; PF0990.
GeneIDi1468855.
KEGGipfu:PF0990.

Phylogenomic databases

eggNOGiCOG0072.
HOGENOMiHOG000105094.
KOiK01890.
OMAiFPMMGVE.

Family and domain databases

Gene3Di3.30.56.20. 1 hit.
HAMAPiMF_00284. Phe_tRNA_synth_beta2.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR004531. Phe-tRNA-synth_IIc_bsu_arc.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR022918. Phe_tRNA_ligase_beta2_bac/arc.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 2 hits.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00471. pheT_arch. 1 hit.
PROSITEiPS51483. B5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiSYFB_PYRFU
AccessioniPrimary (citable) accession number: Q8U260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.