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Q8U1U1 (PYRF_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:PF1114
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134615

Regions

Region57 – 6610Substrate binding By similarity
Region162 – 17211Substrate binding By similarity

Sites

Active site591Proton donor By similarity
Binding site71Substrate By similarity
Binding site291Substrate By similarity
Binding site1091Substrate By similarity
Binding site1851Substrate; via amide nitrogen By similarity
Binding site1861Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8U1U1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 478328C3009352E2

FASTA21123,356
        10         20         30         40         50         60 
MIVLALDVYE REKALSIAED VKDYISMIKV NWPLIIGSGL GVISELKKKT GLPIIADLKL 

        70         80         90        100        110        120 
ADIPNTNRLI AKKVYDAGAD YIILHSFVGR DSVKAVKELG EIIMIVEMSH PGALEFINPL 

       130        140        150        160        170        180 
TDKFIDMANE IKPFGVIAPG TRPERIRYIR ERLSKDIKVL TPGIGAQGGS PVEALKAGAD 

       190        200        210 
YIIIGRAIYN AERPREAAKK IFEEVKEWSS R 

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL81238.1.
RefSeqNP_578843.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8U1U1.
SMRQ8U1U1. Positions 1-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1114.

Proteomic databases

PRIDEQ8U1U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL81238; AAL81238; PF1114.
GeneID1468983.
KEGGpfu:PF1114.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226069.
KOK01591.
OMATEMSHPG.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PYRFU
AccessionPrimary (citable) accession number: Q8U1U1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways