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Protein

Iron-sulfur cluster carrier protein

Gene

PF1145

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPUniRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster carrier proteinUniRule annotation
Gene namesi
Ordered Locus Names:PF1145
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001849551 – 295Iron-sulfur cluster carrier proteinAdd BLAST295

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1145.

Structurei

3D structure databases

ProteinModelPortaliQ8U1R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mrp/NBP35 ATP-binding proteins family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00585. Archaea.
COG0489. LUCA.
HOGENOMiHOG000079916.
OMAiATDCKLI.

Family and domain databases

CDDicd02037. MRP-like. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
IPR033756. YlxH/NBP35.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U1R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKAPTLNV PGLGVDPLTQ RIKEKEKKWK YKIAVLSGKG GVGKSTVAVN
60 70 80 90 100
LTAALAKMGY FVGILDADIH GPNVAKMFGI GNTDIYAEKF EDGHFEMIPP
110 120 130 140 150
TVDFMGQVTP IKVMSMGMMV PEDQPIIWRG SLVTKAIKQL LGDVMWGELD
160 170 180 190 200
FMIIDFPPGT GDEILTVVQS IQLDAAIVVT TPQEVALLDT GKAVNMMKKM
210 220 230 240 250
EVPYIAVIEN MSYLICPHCG NKIDIFGEGG GEKLAEKEGV DFLGKVPIDL
260 270 280 290
KAREASDLGI PIVLYGDTPA AKAFMEIAEK LVNKLKEIKG DGREK
Length:295
Mass (Da):32,010
Last modified:June 1, 2002 - v1
Checksum:i10F73C4A7B24937C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81269.1.
RefSeqiWP_011012285.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81269; AAL81269; PF1145.
GeneIDi1469014.
KEGGipfu:PF1145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81269.1.
RefSeqiWP_011012285.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U1R0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81269; AAL81269; PF1145.
GeneIDi1469014.
KEGGipfu:PF1145.

Phylogenomic databases

eggNOGiarCOG00585. Archaea.
COG0489. LUCA.
HOGENOMiHOG000079916.
OMAiATDCKLI.

Family and domain databases

CDDicd02037. MRP-like. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
IPR033756. YlxH/NBP35.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPBC_PYRFU
AccessioniPrimary (citable) accession number: Q8U1R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.