Q8U1P6 (MFNA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25

Gene names

Name:	mfnA
Ordered Locus Names:	PF1159

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus furiosus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610
Catalytic activity	L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tyrosine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP tyrosine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	L-tyrosine decarboxylase HAMAP-Rule MF_01610		PRO_0000147029
Amino acid modifications
	Modified residue	232	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8U1P6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 35570E479E145AE5	FASTA	371	40,996
	10 20 30 40 50 60 MKFPRKGIPQ EEVMRELEKY TSKDLSFSSG KILGSMCTLP HELAKEVFCM YMDRNLGDPG 70 80 90 100 110 120 LHPGTKKIEE EVIEMLSDLL HLERGYGHIV SGGTEANILA VRAFRNLADV ENPELILPKS 130 140 150 160 170 180 AHFSFIKAGE MLGVKLIWAD LNPDYTVDVK DVEAKISENT IGIVGIAGTT GLGVVDDIPA 190 200 210 220 230 240 LSDLARDYGI PLHVDAAFGG FVIPFAKELG YDLPDFDFKL KGVQSITIDP HKMGMAPIPA 250 260 270 280 290 300 GGIVFRHKKY LRAISVLAPY LAGGKIWQAT ITGTRPGASV LAVWALIKHL GFEGYMEIVD 310 320 330 340 350 360 RAMKLSRWFA EEIKKTPGAW LVREPMLNIV SFKTKNLRRV ERELKSRGWG ISAHRGYIRI 370 VSHASCDGGH D

References

[1]

"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81283.1.
RefSeq	NP_578888.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U1P6.
ModBase	Search...
Protein-protein interaction databases
STRING	186497.PF1159.
Proteomic databases
PRIDE	Q8U1P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL81283; AAL81283; PF1159.
GeneID	1469028.
KEGG	pfu:PF1159.
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HOG000246269.
KO	K01592.
OMA	DLTFDSG.
ProtClustDB	PRK13520.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAP	MF_01610. Tyr_decarbox.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. IPR020931. Tyr_deCO2ase. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MFNA_PYRFU

Accession

Primary (citable) accession number: Q8U1P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program