Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8U1M0 (CDR_PYRFU)

Last modified November 3, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Coenzyme A disulfide reductase
      Short name=CoA-disulfide reductase
      Short name=CoADR
    EC=1.8.1.14
Gene names
Ordered Locus Names: PF1186
OrganismPyrococcus furiosus [Complete proteome] [HAMAP]
Taxonomic identifier2261 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Hide | Top

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

2 CoA + NAD(P)+ = CoA-disulfide + NAD(P)H.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Coenzyme A disulfide reductase
PRO_0000184698

Regions

Nucleotide binding10 – 3526FAD By similarity
Nucleotide binding151 – 16616NADP By similarity
Nucleotide binding270 – 28011FAD By similarity

Sites

Active site451Nucleophile By similarity
Active site451Redox-active By similarity
Binding site171Substrate By similarity
Binding site211Substrate By similarity
Binding site241Substrate By similarity
Binding site411Substrate By similarity
Binding site721Substrate By similarity
Binding site4221FAD; via carbonyl oxygen By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8U1M0-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2329E5F596F1CA6A

FASTA44248,720
        10         20         30         40         50         60 
MEKKKVVIIG GGAAGMSAAS RVKRLRPEWD VKVFEATEWV SHAPCGIPYV VEGIAPKEKL 

        70         80         90        100        110        120 
MHYPPEVFIK KRGIDLHLKA EVIEVETGYV RVRENGEEKS YEWDYLVFAN GASPQIPEIE 

       130        140        150        160        170        180 
GVDLPGVFTA DLPPDAVAIT EYMEKNKVED VVIIGTGYIA LEMAEAFVTR GKNVTLIGRS 

       190        200        210        220        230        240 
ERVLRKTFDK EITDIVEEKL RQHLNLRLHE KTLSIEGRER VEKVITDGGE YKADLVIIAT 

       250        260        270        280        290        300 
GIKPNVELAK QLGVKIGETG AIWTNEKMQT SVENVYAAGD VAETKHVITG KRVWIPLAPA 

       310        320        330        340        350        360 
GNKMGYVAGS NIAGKEIEFP GVLGTSITKF MDLEIGKTGL TENEAVKEGY DVRTAFIKAN 

       370        380        390        400        410        420 
TKPHYYPGGR EIWLKGVVDN ETNRLLGVQA VGAEILPRID SAAAMITAGF TTKDVFFTDL 

       430        440 
AYAPPFAPVW DPLIVLARVL KF

« Hide

Hide | Top

References

[1]"The complete sequence of the Pyrococcus furiosus genome."
Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Hide | Top

Cross-references

Sequence databases

AE009950 Genomic DNA. Translation: AAL81310.1.
RefSeqNP_578915.1.

3D structure databases

HSSPHSSP built from PDB template 1NHP based on UniProtKB P37062.
ModBaseSearch...

Genome annotation databases

GeneID1469056.
GenomeReviewsGene locus PF1186 in contig AE009950_GR.
KEGGpfu:PF1186.
NMPDRfig|186497.1.peg.1227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8U1M0.
OMADVAETKH.

Enzyme and pathway databases

BRENDA1.8.1.14. 321.

Family and domain databases

InterProIPR017758. CoA_disulphide_reductase.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR001327. Pyr_OxRdtase_NAD_bd.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
PfamPF00070. Pyr_redox. 2 hits.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
ProDomPD000139. FAD_pyr_redox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03385. CoA_CoA_reduc. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry nameCDR_PYRFU
AccessionPrimary (citable) accession number: Q8U1M0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents