Q8U1F0 (RPIA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	PF1258

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: InterPro
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Ribose-5-phosphate isomerase A HAMAP MF_00170		PRO_0000158516

Sequences

	Sequence		Length	Mass (Da)
	Q8U1F0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E6DDE60481159023	FASTA	229	25,194
	10 20 30 40 50 60 MNVEEMKKAV ARAALEFIED DMVVGLGTGS TTAYFIRYLG EMIEKGKVED IYGVPPPIKQ 70 80 90 100 110 120 KFLRMESGVP VLSLDQVDAI DIAVDGADEV DPNLNLIKGR GAALTMEKII EYRAGTFIVL 130 140 150 160 170 180 VDESKLVDYL CQKMPVPIEV IPAAWKAILE ELSIFNAKAE LRMGVKKDGP VVTENGNFII 190 200 210 220 DAKFPRIDDP LDMEIELNTI PGVVENGIFA DIADIVLVGT KEGVKRLER

References

[1]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81382.1.
RefSeq	NP_578987.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U1F0.
SMR	Q8U1F0. Positions 1-229.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000004431; EBPYRP00000004292; EBPYRG00000004431.
GeneID	1469131.
GenomeReviews	Gene locus PF1258 in contig AE009950_GR.
KEGG	pfu:PF1258.
NMPDR	fig|186497.1.peg.1302.
Phylogenomic databases
GeneTree	EBGT00050000022434.
HOGENOM	HBG515603.
OMA	IPMAITP.
PhylomeDB	Q8U1F0.
ProtClustDB	PRK00702.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A. [Tree]
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. IPR014036. Tscrpt_reg_HTH_DeoR. [Graphical view]
KO	K01807.
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF00455. DeoR. 1 hit. PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. RpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_PYRFU

Accession

Primary (citable) accession number: Q8U1F0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program