Reviewed, UniProtKB/Swiss-Prot Q8U151 (RNP2_PYRFU)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 2
      Short name=RNase P component 2
    EC=3.1.26.5

Gene names

Name:	rnp2
Ordered Locus Names:	PF1378

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00755
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 120

120

Ribonuclease P protein component 2 HAMAP MF_00755

PRO_0000140026

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

120

Helix Strand Turn

Details...

Beta strand

16 – 27

12

Helix

31 – 54

24

Beta strand

57 – 62

6

Turn

63 – 66

4

Beta strand

67 – 73

7

Helix

74 – 76

3

Helix

77 – 85

9

Beta strand

93 – 105

13

Helix

106 – 112

7

Turn

113 – 118

6

Sequences

	Sequence		Length	Mass (Da)
	Q8U151-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B690DF4C26299915	FASTA	120	13,839
	10 20 30 40 50 60 MSERPKTLPP TLRDKKRYIA FKVISENQFN KDEIKEAIWN ACLRTLGELG TAKAKPWLIK 70 80 90 100 110 120 FDETTQTGII RCDRNHVYDV IFSLTLVSDI NGNKAIIKVL GVSGTIKRLK RKFLSQFGWR

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE009950 Genomic DNA. Translation: AAL81502.1.

RefSeq

NP_579107.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AV5	X-ray	3.15	A/B/C/D/E	1-120	[»]

ModBase

Search...

Genome annotation databases

GeneID

1469254.

GenomeReviews

Gene locus PF1378 in contig AE009950_GR.

KEGG

pfu:PF1378.

NMPDR

fig|186497.1.peg.1425.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

Q8U151.

OMA

LKTLPPT.

Enzyme and pathway databases

BRENDA

3.1.26.5. 321.

Family and domain databases

HAMAP

MF_00755.
[Tree]

InterPro

IPR016434. RNase_P_comp-2.
IPR002759. RNase_P_related.
[Graphical view]

Pfam

PF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]

PIRSF

PIRSF004952. RNase_P_2. 1 hit.

ProtoNet

Search...

Entry information

Entry name

RNP2_PYRFU

Accession

Primary (citable) accession number: Q8U151

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)