Reviewed, UniProtKB/Swiss-Prot Q8U151 (RNP2_PYRFU)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 2
      Short name=RNase P component 2
    EC=3.1.26.5

Gene names

Name:	rnp2
Ordered Locus Names:	PF1378

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP MF_00755
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00755
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential. HAMAP MF_00755
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 120

120

Ribonuclease P protein component 2 HAMAP MF_00755

PRO_0000140026

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

120

Helix Strand Turn

Details...

Beta strand

16 – 27

12

Helix

31 – 54

24

Beta strand

57 – 62

6

Turn

63 – 66

4

Beta strand

67 – 73

7

Helix

74 – 76

3

Helix

77 – 85

9

Beta strand

93 – 105

13

Helix

106 – 112

7

Turn

113 – 118

6

Sequences

	Sequence		Length	Mass (Da)
	Q8U151-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B690DF4C26299915	FASTA	120	13,839
	10 20 30 40 50 60 MSERPKTLPP TLRDKKRYIA FKVISENQFN KDEIKEAIWN ACLRTLGELG TAKAKPWLIK 70 80 90 100 110 120 FDETTQTGII RCDRNHVYDV IFSLTLVSDI NGNKAIIKVL GVSGTIKRLK RKFLSQFGWR

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE009950 Genomic DNA. Translation: AAL81502.1.

RefSeq

NP_579107.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AV5	X-ray	3.15	A/B/C/D/E	1-120	[»]

ModBase

Search...

Genome annotation databases

GeneID

1469254.

GenomeReviews

Gene locus PF1378 in contig AE009950_GR.

KEGG

pfu:PF1378.

NMPDR

fig|186497.1.peg.1425.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG551631.

OMA

LKTLPPT.

Enzyme and pathway databases

BRENDA

3.1.26.5. 321.

Family and domain databases

HAMAP

MF_00755. RNase_P_2.
[Tree]

InterPro

IPR016434. RNase_P_comp-2.
IPR002759. RNase_P_related.
[Graphical view]

Pfam

PF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]

PIRSF

PIRSF004952. RNase_P_2. 1 hit.

ProtoNet

Search...

Entry information

Entry name

RNP2_PYRFU

Accession

Primary (citable) accession number: Q8U151

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)