Q8U111 (PGP_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycolate phosphatase
Short name=PGP
Short name=PGPase
EC=3.1.3.18

Gene names

Ordered Locus Names:

PF1419

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of 2-phosphoglycolate By similarity. HAMAP MF_01419
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_01419
Cofactor	Magnesium By similarity. HAMAP MF_01419
Sequence similarities	Belongs to the archaeal SPP-like hydrolase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Phosphoglycolate phosphatase HAMAP MF_01419		PRO_0000146724
Sites
	Active site	9	1	Nucleophile By similarity
	Metal binding	9	1	Magnesium By similarity
	Metal binding	11	1	Magnesium By similarity
	Metal binding	177	1	Magnesium By similarity
	Metal binding	181	1	Magnesium By similarity
	Binding site	154	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8U111 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: CA251F366C743441	FASTA	231	25,506
	10 20 30 40 50 60 MKIKAISLDI DGTITYPNRM IHEEALQAIR KAESLGVPIM LVTGNTVQFA EAASILIGTS 70 80 90 100 110 120 GPVVAEDGGA ISYKKKRIFL TSMDEEWILW GELKKRFPNV KTSHTMPDRR AGLVIMRETI 130 140 150 160 170 180 DVETVRKLIK ELNLNLVAVD SGFAIHVKKP WINKGSGIEK ACELLGLNPK EVAHVGDGEN 190 200 210 220 230 DLDAFKVVGY RIAVAQAPKI LKENADYITQ NEYGKGGAEA IYHILEKFGY I

References

[1]

"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81543.1.
RefSeq	NP_579148.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U111.
SMR	Q8U111. Positions 1-231.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000004177; EBPYRP00000004038; EBPYRG00000004177.
GeneID	1469295.
GenomeReviews	Gene locus PF1419 in contig AE009950_GR.
KEGG	pfu:PF1419.
NMPDR	fig|186497.1.peg.1466.
Phylogenomic databases
GeneTree	EBGT00050000023028.
HOGENOM	HBG551920.
OMA	VTGNTVQ.
PhylomeDB	Q8U111.
ProtClustDB	PRK01158.
Family and domain databases
HAMAP	MF_01419. GPH_hydrolase_arch. [Tree]
InterPro	IPR023214. HAD-like_dom. IPR013200. HAD-SF_hydro-like_3. IPR006382. SPPlik_hydro_arc. IPR006378. Suc_phosP. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K07024.
Pfam	PF08282. Hydrolase_3. 2 hits. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01487. SPP-like. 1 hit. TIGR01482. SPP-subfamily. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGP_PYRFU

Accession

Primary (citable) accession number: Q8U111

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program