Reviewed, UniProtKB/Swiss-Prot Q8U111 (PGP_PYRFU)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

PF1419

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of 2-phosphoglycolate By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_01419
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the archaeal SPP-like hydrolase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Phosphoglycolate phosphatase HAMAP MF_01419		PRO_0000146724
Sites
	Active site	9	1	Nucleophile By similarity
	Metal binding	9	1	Magnesium By similarity
	Metal binding	11	1	Magnesium By similarity
	Metal binding	177	1	Magnesium By similarity
	Metal binding	181	1	Magnesium By similarity
	Binding site	154	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8U111-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: CA251F366C743441	FASTA	231	25,506
	10 20 30 40 50 60 MKIKAISLDI DGTITYPNRM IHEEALQAIR KAESLGVPIM LVTGNTVQFA EAASILIGTS 70 80 90 100 110 120 GPVVAEDGGA ISYKKKRIFL TSMDEEWILW GELKKRFPNV KTSHTMPDRR AGLVIMRETI 130 140 150 160 170 180 DVETVRKLIK ELNLNLVAVD SGFAIHVKKP WINKGSGIEK ACELLGLNPK EVAHVGDGEN 190 200 210 220 230 DLDAFKVVGY RIAVAQAPKI LKENADYITQ NEYGKGGAEA IYHILEKFGY I

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010245 Genomic DNA. Translation: AAL81543.1.
RefSeq	NP_579148.1.
3D structure databases
SMR	Q8U111. Positions 1-231.
ModBase	Search...
Genome annotation databases
GeneID	1469295.
GenomeReviews	Gene locus PF1419 in contig AE009950_GR.
KEGG	pfu:PF1419.
NMPDR	fig|186497.1.peg.1466.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8U111.
OMA	Q8U111. DEEWILW.
Enzyme and pathway databases
BRENDA	3.1.3.18. 321.
Family and domain databases
HAMAP	MF_01419. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006379. HAD-SF_hydro_IIB. IPR006382. SPPlik_hydro_arc. IPR006378. Suc_phosP. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit. TIGR01487. SPP-like. 1 hit. TIGR01482. SPP-subfamily. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGP_PYRFU

Accession

Primary (citable) accession number: Q8U111

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)