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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtc

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the GTP-dependent conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.1 Publication

Miscellaneous

Generally, RNA 3'-terminal phosphate cyclases are ATP dependent, but P.furiosus enzyme preferentially uses GTP rather than ATP.1 Publication

Catalytic activityi

GTP + (RNA)-3'-(3'-phospho-ribonucleoside) = GMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.1 Publication

Enzyme regulationi

Inhibited by GMP.1 Publication

Temperature dependencei

Optimum temperature is 95 degrees Celsius.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, RNA-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.5.1.5 5243

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclaseUniRule annotation (EC:6.5.1.51 Publication)
Short name:
RNA cyclaseUniRule annotation
Short name:
RNA-3'-phosphate cyclaseUniRule annotation
Alternative name(s):
GTP-dependent RNA 3'-terminal-phosphate cyclaseCurated
Gene namesi
Name:rtc1 Publication
Synonyms:rtcAUniRule annotation
Ordered Locus Names:PF1549
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564321 – 342RNA 3'-terminal phosphate cyclaseAdd BLAST342

Proteomic databases

PRIDEiQ8U0N7

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1549

Structurei

3D structure databases

ProteinModelPortaliQ8U0N7
SMRiQ8U0N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04125 Archaea
COG0430 LUCA
HOGENOMiHOG000015264
KOiK18105
OMAiANRPKPG
OrthoDBiPOG093Z05RD

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF52913 SSF52913, 1 hit
SSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U0N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIIDGSYGE GGGQILRTSI ALSAITGEPV KIINIRANRP NPGLRPQHLN
60 70 80 90 100
AILALKKLAN AKVEGAEVGS REVTFIPGEL KGGEIRVDIG TAGSITLVLQ
110 120 130 140 150
ALLPAMVFAK DTVEFKITGG TDVSWSPPVD YLINVTMFAL RKIGIEGEIK
160 170 180 190 200
LLRRGHYPKG GGIVAGYVKP WIERKELIAE EFENIYKVSG ISHATNLPAH
210 220 230 240 250
VAERQAKAAM EELKVLGVPI EIKKEVSHSL GPGSGIVVWA ETECLRLGGD
260 270 280 290 300
ALGKKGKPAE EVGREAAQEL LSQVKTKACV DKFLGDQIIP FLAISGGKIK
310 320 330 340
VAEITKHLIT NVWVVEQFFG KVFEVKGGVG EKGEVRVVRK AW
Length:342
Mass (Da):36,804
Last modified:June 1, 2002 - v1
Checksum:iD4D2E5898CB3B4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81673.1
RefSeqiWP_011012696.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81673; AAL81673; PF1549
GeneIDi1469425
KEGGipfu:PF1549
PATRICifig|186497.12.peg.1615

Similar proteinsi

Entry informationi

Entry nameiRTCA_PYRFU
AccessioniPrimary (citable) accession number: Q8U0N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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