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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:PF1555
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Probable tRNA pseudouridine synthase DPRO_0000152551Add
BLAST

Proteomic databases

PRIDEiQ8U0N1.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1555.

Structurei

3D structure databases

ProteinModelPortaliQ8U0N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 372222TRUDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252. Archaea.
COG0585. LUCA.
HOGENOMiHOG000224849.
KOiK06176.
OMAiLRYERAM.

Family and domain databases

HAMAPiMF_01082. TruD. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U0N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPVGGLKY LTTSPGIGGK IKVYPEDFIV KEVIPKSIFK AGKCKIYILK
60 70 80 90 100
KKNWETMAAI KEIAKRVGVH YSEIGFAGTK DRHAVTYQYI SICRDVNLEE
110 120 130 140 150
VKIRDIELKF VGYGRPLKLG FLLGNFFKIR VRESNPSLLP SVIEEAKEKG
160 170 180 190 200
GFPNYFGIQR FGEKRSVNHV VGKLLLLGKY EEAAEVFLGF PGKGMEGDEA
210 220 230 240 250
RRKFLETKDV DLALREFPNF LRYERAMLYR YKETGSWKKA FLVLPRPILR
260 270 280 290 300
IFIHSFQSYL FNLYLSRRIE EGLPLNKALP GDIVIQVKKG IPLRKRTYRV
310 320 330 340 350
TENNVDFVNR KIKEGEAMVS GPIFGYMYRK GKGIPGRLEE EILEEAGVKL
360 370 380 390 400
EYFKKLPKPM REPGGRRELL IRPMKFAYKV EDRDVIFRFF LPKGVYATSV

LREIMKN
Length:407
Mass (Da):46,976
Last modified:June 1, 2002 - v1
Checksum:i5997BB0BD11780EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81679.1.
RefSeqiWP_011012702.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81679; AAL81679; PF1555.
GeneIDi1469431.
KEGGipfu:PF1555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81679.1.
RefSeqiWP_011012702.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U0N1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1555.

Proteomic databases

PRIDEiQ8U0N1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81679; AAL81679; PF1555.
GeneIDi1469431.
KEGGipfu:PF1555.

Phylogenomic databases

eggNOGiarCOG04252. Archaea.
COG0585. LUCA.
HOGENOMiHOG000224849.
KOiK06176.
OMAiLRYERAM.

Family and domain databases

HAMAPiMF_01082. TruD. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_PYRFU
AccessioniPrimary (citable) accession number: Q8U0N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.