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Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A''UniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:rpoA2UniRule annotation
Ordered Locus Names:PF1562
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740221 – 397DNA-directed RNA polymerase subunit A''Add BLAST397

Proteomic databases

PRIDEiQ8U0M5.

Interactioni

Protein-protein interaction databases

IntActiQ8U0M5. 1 interactor.
MINTiMINT-8173461.
STRINGi186497.PF1562.

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi345 – 35410
Beta strandi357 – 3593

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QQCX-ray3.30A334-371[»]
ProteinModelPortaliQ8U0M5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U0M5.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

CDDicd06528. RNAP_A''. 1 hit.
HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U0M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLSTIKSL IEKKGANLPE NVKSELYEKL KKYNEKYKLT KAEIEAIIDD
60 70 80 90 100
VVKEYERALV EPGEPVGTVA AQSIGEPSTQ MTLNTFHYAG VAEINVTLGL
110 120 130 140 150
PRIIEIVDAR KNPSTPMMTV YLDEEHRYDR AKAEEVARRI EGTTLENLAR
160 170 180 190 200
STTLDLINFE FIVEIDPERL ERSGLTMEKV VKKLESSFKS AEFEVDGYTL
210 220 230 240 250
IVRPKKADKI SDLRRFAEKI KKHRLKGLSG VGKTIVRKEG DEYVIYTEGS
260 270 280 290 300
NFKQVLKVPG VDPTRTRTNN IHEIAEVLGI EAARNAIIDE IVSTMQEQGL
310 320 330 340 350
EVDIRHIMLV ADMMTLDGIV RPIGRHGVVG EKSSVLARAA FEITVQHLFE
360 370 380 390
AAEKGEVDNL NGVIENVLIG QPVPVGTGMV KLTMKLPLRP QKEKEEV
Length:397
Mass (Da):44,404
Last modified:June 1, 2002 - v1
Checksum:i19D46E356CA0E49F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81686.1.
RefSeqiWP_011012708.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81686; AAL81686; PF1562.
GeneIDi1469438.
KEGGipfu:PF1562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81686.1.
RefSeqiWP_011012708.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QQCX-ray3.30A334-371[»]
ProteinModelPortaliQ8U0M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8U0M5. 1 interactor.
MINTiMINT-8173461.
STRINGi186497.PF1562.

Proteomic databases

PRIDEiQ8U0M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81686; AAL81686; PF1562.
GeneIDi1469438.
KEGGipfu:PF1562.

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Miscellaneous databases

EvolutionaryTraceiQ8U0M5.

Family and domain databases

CDDicd06528. RNAP_A''. 1 hit.
HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPOA2_PYRFU
AccessioniPrimary (citable) accession number: Q8U0M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.