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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:PF1571
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241831 – 260Proteasome subunit alphaAdd BLAST260

Proteomic databases

PRIDEiQ8U0L6.

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1571.

Structurei

3D structure databases

ProteinModelPortaliQ8U0L6.
SMRiQ8U0L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00971. Archaea.
COG0638. LUCA.
HOGENOMiHOG000091085.
KOiK03432.
OMAiQMGYDRA.
OrthoDBiPOG093Z086S.

Family and domain databases

CDDicd03756. proteasome_alpha_archeal. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_A. Proteasome_A_A. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR019982. Proteasome_asu_arc.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03633. arc_protsome_A. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVPPQAGY DRAITVFSPD GRLFQVNYAR EAVKRGATAV GVKCGEGVVL
60 70 80 90 100
AVEKRITSRL IEPDSYEKIF QIDDHIAAAS SGIIADARVL VNRARLEAQI
110 120 130 140 150
YRLTYGEPAP VSVIVKKICD LKQMHTQYGG VRPFGAALLM AGINDRPELY
160 170 180 190 200
ETDPSGAYFA WKAVAIGSGR NTAMAIFEEK YRDDMNLEDA IKLALMALAK
210 220 230 240 250
TMENPSADNI EVAVITVKDK KFRKLTRDEI EKYLSEVLKE VEEEEVKEKE
260
EDYSELDSNY
Length:260
Mass (Da):29,009
Last modified:June 1, 2002 - v1
Checksum:i2CA52E105288FFA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81695.1.
RefSeqiWP_011012717.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81695; AAL81695; PF1571.
GeneIDi1469447.
KEGGipfu:PF1571.
PATRICifig|186497.12.peg.1637.

Similar proteinsi

Entry informationi

Entry nameiPSA_PYRFU
AccessioniPrimary (citable) accession number: Q8U0L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families