Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan synthase beta chain 2

Gene

trpB2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 2 (EC:4.2.1.20)
Gene namesi
Name:trpB2
Ordered Locus Names:PF1592
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000990511 – 446Tryptophan synthase beta chain 2Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi186497.PF1592

Structurei

3D structure databases

ProteinModelPortaliQ8U0J5
SMRiQ8U0J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiarCOG01432 Archaea
COG1350 LUCA
HOGENOMiHOG000161709
KOiK06001
OMAiPPIHAGG
OrthoDBiPOG093Z033G

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006316 Trp_synth_b-like
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR43565 PTHR43565, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
PIRSF500824 TrpB_prok, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01415 trpB_rel, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U0J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVLPDGRI PRRWYNILPD LPEPLAPPLD PETNEPVDPK KLERIFAKEL
60 70 80 90 100
VKQEMSTKRY IKIPEEVRKM YSKIGRPTPL FRATNLEKYL NTPARIYFKF
110 120 130 140 150
EGATVTGSHK INTALAQAYY AKKEGIERLV TETGAGQWGT ALSLAGALMG
160 170 180 190 200
IKVRVYMARA SYEQKPYRKV LMRIYGAEVF PSPSENTEIG KRFLSENPNH
210 220 230 240 250
PGSLGIAISE AIEDVLKDEK ARYSLGSVLN HVLMHQTVIG LEAKQQMEEF
260 270 280 290 300
EEPDVIIGCV GGGSNFAGLA YPFVKEVLDG DNEYEFIAVE PKAAPSMTRG
310 320 330 340 350
VYTYDFGDSG ELTPKLKMHT LGHRYHVPPI HAGGLRYHGV APTLSVLVNN
360 370 380 390 400
GIVKPIAYHQ TEVFEAAALF AKLEGIVPAP ESAHAIKATI DKAIEAKREG
410 420 430 440
KEIVILFNLS GHGLLDLHGY EEYLEGRLQD YEPKDLPISN PLNPKP
Length:446
Mass (Da):49,616
Last modified:June 1, 2002 - v1
Checksum:i11564BFD6C41A64F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81716.1
RefSeqiWP_011012738.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81716; AAL81716; PF1592
GeneIDi1469468
KEGGipfu:PF1592
PATRICifig|186497.12.peg.1658

Similar proteinsi

Entry informationi

Entry nameiTRPB2_PYRFU
AccessioniPrimary (citable) accession number: Q8U0J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health