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Q8U0G6 (PDAD_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvoyl-dependent arginine decarboxylase

Short name=PvlArgDC
EC=4.1.1.19
Gene names
Name:pdaD
Ordered Locus Names:PF1623
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01404

Cofactor

Pyruvoyl group By similarity. HAMAP-Rule MF_01404

Sequence similarities

Belongs to the PdaD family.

Ontologies

Keywords
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionarginine decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4343Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity
PRO_0000023330
Chain44 – 158115Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity
PRO_0000023331

Sites

Site43 – 442Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue441Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8U0G6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 6441F3D6306F200C

FASTA15817,108
        10         20         30         40         50         60 
MSWITPKKAI MLAAAAEGGT KLNAFDNALL KMGIGNVNLV KLSSVIPAHI EWLDELPKNI 

        70         80         90        100        110        120 
PIGMLLPTVY THIESDEPGS TISAALGIGL SEGNEGGLIY EYSGYCKKEE AEEMVKKMVE 

       130        140        150 
EGFRVRGWKL KEIKIVSAEI TVKDKPAAAV AAVVMFPY 

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL81747.1.
RefSeqNP_579352.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8U0G6.
SMRQ8U0G6. Positions 3-43.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1623.

Proteomic databases

PRIDEQ8U0G6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL81747; AAL81747; PF1623.
GeneID1469500.
KEGGpfu:PF1623.

Phylogenomic databases

eggNOGCOG1945.
HOGENOMHOG000012204.
KOK02626.
OMAISSIMPP.
ProtClustDBPRK01285.

Family and domain databases

Gene3D3.50.20.10. 1 hit.
HAMAPMF_01404. PvlArgDC.
InterProIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamPF01862. PvlArgDC. 1 hit.
[Graphical view]
PIRSFPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56271. SSF56271. 1 hit.
TIGRFAMsTIGR00286. TIGR00286. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDAD_PYRFU
AccessionPrimary (citable) accession number: Q8U0G6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families