Q8U0F3 (KIME_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mevalonate kinase
Short name=MK
EC=2.7.1.36

Gene names

Name:	mvk
Ordered Locus Names:	PF1637

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. HAMAP MF_00217
Cofactor	Magnesium By similarity. HAMAP MF_00217
Subunit structure	Homodimer By similarity. HAMAP MF_00217
Subcellular location	Cytoplasm Probable HAMAP MF_00217.
Sequence similarities	Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mevalonate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Mevalonate kinase HAMAP MF_00217		PRO_0000156668
Regions
	Nucleotide binding	110 – 120	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8U0F3 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B1ABB8A1994B5083	FASTA	334	35,606
	10 20 30 40 50 60 MKVIASAPAK VILFGEHSVV YGKPAIAAAI DLRTFVEAEL IREKKIRIEA HDIKVPGLTV 70 80 90 100 110 120 SFSENEIYFE TDYGKAAEVL SYVREAINLV LEEADKKNVG IKVSITSQIP VGAGLGSSAA 130 140 150 160 170 180 VAVATIGAVS KLLGLELSKE EIAKMGHKTE LLVQGASSGI DPTVSAIGGF IFYEKGKFEH 190 200 210 220 230 240 LPFMELPIVV GYTGSSGPTK ELVAMVRKRY EEMPELIVPI LEAMGKVVEK AKDVILSNVD 250 260 270 280 290 300 KEEKFERLGV LMNINHGLLD ALGVSTKKLS ELVYAARVAG ALGAKITGAG GGGCMYALAP 310 320 330 NKQREVATAI RIAGGTPMIT EISREGLKIE EVIK

References

[1]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81761.1.
RefSeq	NP_579366.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U0F3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000005318; EBPYRP00000005179; EBPYRG00000005317.
GeneID	1469514.
GenomeReviews	Gene locus PF1637 in contig AE009950_GR.
KEGG	pfu:PF1637.
NMPDR	fig|186497.1.peg.1685.
Phylogenomic databases
GeneTree	EBGT00050000023109.
HOGENOM	HBG646485.
OMA	EIGKGEC.
PhylomeDB	Q8U0F3.
ProtClustDB	PRK03926.
Family and domain databases
HAMAP	MF_00217. Mevalonate_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR006205. Mev_gal_kin. IPR006206. Mevalonate/galactokinase. IPR022937. Mevalonate_kinase_arc. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00869.
PANTHER	PTHR10457:SF4. Mev_gal_kin. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PRINTS	PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00549. Mevalon_kin. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KIME_PYRFU

Accession

Primary (citable) accession number: Q8U0F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program