Reviewed, UniProtKB/Swiss-Prot Q8U0F3 (KIME_PYRFU)

Names and origin

Protein names

Recommended name:
    Mevalonate kinase
      Short name=MK
    EC=2.7.1.36

Gene names

Name:	mvk
Ordered Locus Names:	PF1637

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. HAMAP MF_00217
Cofactor	Magnesium By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP mevalonate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Mevalonate kinase HAMAP MF_00217		PRO_0000156668
Regions
	Nucleotide binding	110 – 120	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8U0F3-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B1ABB8A1994B5083	FASTA	334	35,606
	10 20 30 40 50 60 MKVIASAPAK VILFGEHSVV YGKPAIAAAI DLRTFVEAEL IREKKIRIEA HDIKVPGLTV 70 80 90 100 110 120 SFSENEIYFE TDYGKAAEVL SYVREAINLV LEEADKKNVG IKVSITSQIP VGAGLGSSAA 130 140 150 160 170 180 VAVATIGAVS KLLGLELSKE EIAKMGHKTE LLVQGASSGI DPTVSAIGGF IFYEKGKFEH 190 200 210 220 230 240 LPFMELPIVV GYTGSSGPTK ELVAMVRKRY EEMPELIVPI LEAMGKVVEK AKDVILSNVD 250 260 270 280 290 300 KEEKFERLGV LMNINHGLLD ALGVSTKKLS ELVYAARVAG ALGAKITGAG GGGCMYALAP 310 320 330 NKQREVATAI RIAGGTPMIT EISREGLKIE EVIK

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010263 Genomic DNA. Translation: AAL81761.1.
RefSeq	NP_579366.1.
3D structure databases
HSSP	HSSP built from PDB template 1KVK based on UniProtKB P17256.
ModBase	Search...
Genome annotation databases
GeneID	1469514.
GenomeReviews	Gene locus PF1637 in contig AE009950_GR.
KEGG	pfu:PF1637.
NMPDR	fig|186497.1.peg.1685.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8U0F3.
OMA	Q8U0F3. FSSAFFT.
Enzyme and pathway databases
BRENDA	2.7.1.36. 321.
Family and domain databases
HAMAP	MF_00217. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006205. Mev_gal_kin. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
PANTHER	PTHR10457:SF4. Mev_gal_kin. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PRINTS	PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00549. mevalon_kin. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KIME_PYRFU

Accession

Primary (citable) accession number: Q8U0F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)