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Q8U0A9

- Q8U0A9_PYRFU

UniProt

Q8U0A9 - Q8U0A9_PYRFU

Protein
Submitted name:

2-dehydro-3-deoxyphosphoheptonate aldolase

Gene

PF1690

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi31 – 311ManganeseImported
    Metal bindingi201 – 2011Manganese; via tele nitrogenImported
    Metal bindingi227 – 2271ManganeseImported
    Metal bindingi238 – 2381ManganeseImported

    GO - Molecular functioni

    1. 3-deoxy-7-phosphoheptulonate synthase activity Source: UniProtKB-EC
    2. aldehyde-lyase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    TransferaseImported

    Keywords - Ligandi

    ManganeseImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-dehydro-3-deoxyphosphoheptonate aldolaseImported (EC:2.5.1.54Imported)
    Gene namesi
    Ordered Locus Names:PF1690Imported
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8U0A9.

    Interactioni

    Protein-protein interaction databases

    STRINGi186497.PF1690.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZCOX-ray2.25A/B1-262[»]
    4C1KX-ray2.15A/B/C/D/E/F1-262[»]
    4C1LX-ray1.80A/B1-262[»]
    4GRSX-ray3.00A/B/C/D33-262[»]
    ProteinModelPortaliQ8U0A9.
    SMRiQ8U0A9. Positions 1-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8U0A9.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2876.
    HOGENOMiHOG000023020.
    KOiK03856.
    OMAiCERGACM.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006218. DAHP1/KDSA.
    IPR006268. DAHP_syn_2.
    [Graphical view]
    PfamiPF00793. DAHP_synth_1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01361. DAHP_synth_Bsub. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8U0A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYSKEYKEK TVVKINDVKF GEGFTIIAGP CSIESRDQIM KVAEFLAEVG    50
    IKVLRGGAFK PRTSPYSFQG YGEKALRWMR EAADEYGLVT VTEVMDTRHV 100
    ELVAKYSDIL QIGARNSQNF ELLKEVGKVE NPVLLKRGMG NTIQELLYSA 150
    EYIMAQGNEN VILCERGIRT FETATRFTLD ISAVPVVKEL SHLPIIVDPS 200
    HPAGRRSLVI PLAKAAYAIG ADGIMVEVHP EPEKALSDSQ QQLTFDDFLQ 250
    LLKELEALGW KG 262
    Length:262
    Mass (Da):29,225
    Last modified:June 1, 2002 - v1
    Checksum:iED84D28FD5DEADC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81814.1.
    RefSeqiNP_579419.1. NC_003413.1.
    WP_011012836.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81814; AAL81814; PF1690.
    GeneIDi1469567.
    KEGGipfu:PF1690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009950 Genomic DNA. Translation: AAL81814.1 .
    RefSeqi NP_579419.1. NC_003413.1.
    WP_011012836.1. NC_003413.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZCO X-ray 2.25 A/B 1-262 [» ]
    4C1K X-ray 2.15 A/B/C/D/E/F 1-262 [» ]
    4C1L X-ray 1.80 A/B 1-262 [» ]
    4GRS X-ray 3.00 A/B/C/D 33-262 [» ]
    ProteinModelPortali Q8U0A9.
    SMRi Q8U0A9. Positions 1-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF1690.

    Proteomic databases

    PRIDEi Q8U0A9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81814 ; AAL81814 ; PF1690 .
    GeneIDi 1469567.
    KEGGi pfu:PF1690.

    Phylogenomic databases

    eggNOGi COG2876.
    HOGENOMi HOG000023020.
    KOi K03856.
    OMAi CERGACM.

    Miscellaneous databases

    EvolutionaryTracei Q8U0A9.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006218. DAHP1/KDSA.
    IPR006268. DAHP_syn_2.
    [Graphical view ]
    Pfami PF00793. DAHP_synth_1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01361. DAHP_synth_Bsub. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1Imported.
    2. "Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?"
      Schofield L.R., Anderson B.F., Patchett M.L., Norris G.E., Jameson G.B., Parker E.J.
      Biochemistry 44:11950-11962(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH MANGANESE.
    3. "Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain."
      Cross P.J., Allison T.M., Dobson R.C., Jameson G.B., Parker E.J.
      Proc. Natl. Acad. Sci. U.S.A. 110:2111-2116(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 33-262.
    4. "Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity."
      Nazmi A.R., Schofield L.R., Dobson R.C., Jameson G.B., Parker E.J.
      J. Mol. Biol. 426:656-673(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MANGANESE.

    Entry informationi

    Entry nameiQ8U0A9_PYRFU
    AccessioniPrimary (citable) accession number: Q8U0A9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3