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Q8U0A9 (Q8U0A9_PYRFU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=2.5.1.54 EMBL AAL81814.1
Gene names
Ordered Locus Names:PF1690 EMBL AAL81814.1
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP] EMBL AAL81814.1
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding311Cadmium
Metal binding311Manganese PDB 1ZCO PDB 4C1L
Metal binding2011Cadmium; via tele nitrogen
Metal binding2011Manganese; via tele nitrogen PDB 1ZCO PDB 4C1L
Metal binding2271Cadmium
Metal binding2271Manganese PDB 1ZCO PDB 4C1L
Metal binding2381Cadmium
Metal binding2381Manganese PDB 1ZCO PDB 4C1L
Binding site551Chloride 1 PDB 4C1L
Binding site1111Chloride 2 PDB 4C1L
Binding site1151Chloride 3 PDB 1ZCO
Binding site1361Chloride 2 PDB 4C1L
Binding site1361Chloride 4 PDB 4C1L
Binding site1661Chloride 4 PDB 4C1L
Binding site2011Chloride 4 PDB 4C1L

Sequences

Sequence LengthMass (Da)Tools
Q8U0A9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: ED84D28FD5DEADC2

FASTA26229,225
        10         20         30         40         50         60 
MKYSKEYKEK TVVKINDVKF GEGFTIIAGP CSIESRDQIM KVAEFLAEVG IKVLRGGAFK 

        70         80         90        100        110        120 
PRTSPYSFQG YGEKALRWMR EAADEYGLVT VTEVMDTRHV ELVAKYSDIL QIGARNSQNF 

       130        140        150        160        170        180 
ELLKEVGKVE NPVLLKRGMG NTIQELLYSA EYIMAQGNEN VILCERGIRT FETATRFTLD 

       190        200        210        220        230        240 
ISAVPVVKEL SHLPIIVDPS HPAGRRSLVI PLAKAAYAIG ADGIMVEVHP EPEKALSDSQ 

       250        260 
QQLTFDDFLQ LLKELEALGW KG 

« Hide

References

« Hide 'large scale' references
[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]"Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?"
Schofield L.R., Anderson B.F., Patchett M.L., Norris G.E., Jameson G.B., Parker E.J.
Biochemistry 44:11950-11962(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH CHLORIDE AND MANGANESE.
[3]"Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain."
Cross P.J., Allison T.M., Dobson R.C., Jameson G.B., Parker E.J.
Proc. Natl. Acad. Sci. U.S.A. 110:2111-2116(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 33-262.
[4]"Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity."
Nazmi A.R., Schofield L.R., Dobson R.C., Jameson G.B., Parker E.J.
J. Mol. Biol. 426:656-673(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH CADMIUM; CHLORIDE AND MANGANESE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL81814.1.
RefSeqNP_579419.1. NC_003413.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZCOX-ray2.25A/B1-262[»]
4C1KX-ray2.15A/B/C/D/E/F1-262[»]
4C1LX-ray1.80A/B1-262[»]
4GRSX-ray3.00A/B/C/D33-262[»]
ProteinModelPortalQ8U0A9.
SMRQ8U0A9. Positions 1-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1690.

Proteomic databases

PRIDEQ8U0A9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL81814; AAL81814; PF1690.
GeneID1469567.
KEGGpfu:PF1690.

Phylogenomic databases

eggNOGCOG2876.
HOGENOMHOG000023020.
KOK03856.
OMARNSQNFE.
ProtClustDBPRK13398.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006268. DAHP_syn_2.
[Graphical view]
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01361. DAHP_synth_Bsub. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8U0A9.

Entry information

Entry nameQ8U0A9_PYRFU
AccessionPrimary (citable) accession number: Q8U0A9
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)