2-dehydro-3-deoxyphosphoheptonate aldolase - Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Preferred order of sections

Names and origin

Protein names

Submitted name:
2-dehydro-3-deoxyphosphoheptonate aldolase EMBL AAL81814.1
EC=2.5.1.54 EMBL AAL81814.1

Gene names

Ordered Locus Names:

PF1690 EMBL AAL81814.1

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP] EMBL AAL81814.1

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus ›

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Manganese PDB 1ZCO Metal-binding PDB 1ZCO
Molecular function	Transferase EMBL AAL81814.1
Technical term	3D-structure PDB 1ZCO PDB 4GRS Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC aldehyde-lyase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

31

1

Manganese PDB 1ZCO

Metal binding

201

1

Manganese; via tele nitrogen PDB 1ZCO

Metal binding

227

1

Manganese PDB 1ZCO

Metal binding

238

1

Manganese PDB 1ZCO

Sequences

Sequence

Length

Mass (Da)

Tools

Q8U0A9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: ED84D28FD5DEADC2
Show »

FASTA

262

29,225

        10         20         30         40         50         60 
MKYSKEYKEK TVVKINDVKF GEGFTIIAGP CSIESRDQIM KVAEFLAEVG IKVLRGGAFK 

        70         80         90        100        110        120 
PRTSPYSFQG YGEKALRWMR EAADEYGLVT VTEVMDTRHV ELVAKYSDIL QIGARNSQNF 

       130        140        150        160        170        180 
ELLKEVGKVE NPVLLKRGMG NTIQELLYSA EYIMAQGNEN VILCERGIRT FETATRFTLD 

       190        200        210        220        230        240 
ISAVPVVKEL SHLPIIVDPS HPAGRRSLVI PLAKAAYAIG ADGIMVEVHP EPEKALSDSQ 

       250        260 
QQLTFDDFLQ LLKELEALGW KG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?" Schofield L.R., Anderson B.F., Patchett M.L., Norris G.E., Jameson G.B., Parker E.J. Biochemistry 44:11950-11962(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH MANGANESE.
[3]	"Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain." Cross P.J., Allison T.M., Dobson R.C., Jameson G.B., Parker E.J. Proc. Natl. Acad. Sci. U.S.A. 110:2111-2116(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 239-262.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE009950 Genomic DNA. Translation: AAL81814.1.

RefSeq

NP_579419.1. NC_003413.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZCO	X-ray	2.25	A/B	1-262	[»]
4GRS	X-ray	3.00	A/B/C/D	239-262	[»]

ProteinModelPortal

Q8U0A9.

SMR

Q8U0A9. Positions 1-262.

ModBase

Search...

Protein-protein interaction databases

STRING

186497.PF1690.

Proteomic databases

PRIDE

Q8U0A9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAL81814; AAL81814; PF1690.

GeneID

1469567.

KEGG

pfu:PF1690.

Phylogenomic databases

eggNOG

COG2876.

HOGENOM

HOG000023020.

KO

K03856.

OMA

IGANGIM.

ProtClustDB

PRK13398.

Family and domain databases

Gene3D

3.20.20.70. 1 hit.

InterPro

IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006268. DAHP_syn_2.
[Graphical view]

Pfam

PF00793. DAHP_synth_1. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01361. DAHP_synth_Bsub. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8U0A9.

Entry information

Entry name

Q8U0A9_PYRFU

Accession

Primary (citable) accession number: Q8U0A9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)