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Protein

Shikimate kinase

Gene

aroK

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 9511ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:PF1694
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Shikimate kinasePRO_0000141578Add
BLAST

Proteomic databases

PRIDEiQ8U0A5.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1694.

Structurei

3D structure databases

ProteinModelPortaliQ8U0A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01025. Archaea.
COG1685. LUCA.
HOGENOMiHOG000105526.
KOiK00891.
OMAiDATASYY.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00370. Shik_kinase_arch.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR010189. SK_arc.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005758. Shikimt_kin_arch. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01920. Shik_kin_archae. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U0A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLGKGSSA ITVVNAFATG KGGAIGIDLW TEAKVKITDG EVKGKILVNG
60 70 80 90 100
LEFNDFRVVN AVLDVMRRYS GIEFGIEFEI NSEIPVGKGL KSSSAVANAL
110 120 130 140 150
VEAIARALRL NIPGIKVVKL GVEAAKKAGV TLTGAFDDAC ASYFGGLCLT
160 170 180 190 200
DNLRVELLKR IEIDELPVVI LVPNETVLTE ELKGVDFLKI APYVEEAFKL
210 220 230 240 250
AIKGEWKKAL VLNGLIYSTF LSYPPEPISK ALHLGAVVGL SGKGPSVFAI
260 270
TDEPERIEEV WREFGDVIIT STR
Length:273
Mass (Da):29,318
Last modified:June 1, 2002 - v1
Checksum:i7551661EB76E09A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81818.1.
RefSeqiWP_011012840.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81818; AAL81818; PF1694.
GeneIDi1469571.
KEGGipfu:PF1694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81818.1.
RefSeqiWP_011012840.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U0A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1694.

Proteomic databases

PRIDEiQ8U0A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81818; AAL81818; PF1694.
GeneIDi1469571.
KEGGipfu:PF1694.

Phylogenomic databases

eggNOGiarCOG01025. Archaea.
COG1685. LUCA.
HOGENOMiHOG000105526.
KOiK00891.
OMAiDATASYY.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00370. Shik_kinase_arch.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR010189. SK_arc.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005758. Shikimt_kin_arch. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01920. Shik_kin_archae. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiAROK_PYRFU
AccessioniPrimary (citable) accession number: Q8U0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.