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Protein

Shikimate kinase

Gene

aroK

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 95ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:PF1694
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001415781 – 273Shikimate kinaseAdd BLAST273

Proteomic databases

PRIDEiQ8U0A5

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1694

Structurei

3D structure databases

ProteinModelPortaliQ8U0A5
SMRiQ8U0A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01025 Archaea
COG1685 LUCA
HOGENOMiHOG000105526
KOiK00891
OMAiDATASYY
OrthoDBiPOG093Z0EB9

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_00370 Shik_kinase_arch, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR010189 SK_arc
PANTHERiPTHR20861:SF3 PTHR20861:SF3, 1 hit
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF005758 Shikimt_kin_arch, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR01920 Shik_kin_archae, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U0A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLGKGSSA ITVVNAFATG KGGAIGIDLW TEAKVKITDG EVKGKILVNG
60 70 80 90 100
LEFNDFRVVN AVLDVMRRYS GIEFGIEFEI NSEIPVGKGL KSSSAVANAL
110 120 130 140 150
VEAIARALRL NIPGIKVVKL GVEAAKKAGV TLTGAFDDAC ASYFGGLCLT
160 170 180 190 200
DNLRVELLKR IEIDELPVVI LVPNETVLTE ELKGVDFLKI APYVEEAFKL
210 220 230 240 250
AIKGEWKKAL VLNGLIYSTF LSYPPEPISK ALHLGAVVGL SGKGPSVFAI
260 270
TDEPERIEEV WREFGDVIIT STR
Length:273
Mass (Da):29,318
Last modified:June 1, 2002 - v1
Checksum:i7551661EB76E09A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81818.1
RefSeqiWP_011012840.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81818; AAL81818; PF1694
GeneIDi1469571
KEGGipfu:PF1694
PATRICifig|186497.12.peg.1762

Similar proteinsi

Entry informationi

Entry nameiAROK_PYRFU
AccessioniPrimary (citable) accession number: Q8U0A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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