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Q8U093

- TRPB1_PYRFU

UniProt

Q8U093 - TRPB1_PYRFU

Protein

Tryptophan synthase beta chain 1

Gene

trpB1

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase beta chain 1 (EC:4.2.1.20)
    Gene namesi
    Name:trpB1
    Ordered Locus Names:PF1706
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Tryptophan synthase beta chain 1PRO_0000099050Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ8U093.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.By similarity

    Protein-protein interaction databases

    STRINGi186497.PF1706.

    Structurei

    Secondary structure

    1
    388
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 153
    Helixi16 – 3015
    Helixi33 – 4513
    Beta strandi53 – 553
    Helixi57 – 637
    Beta strandi65 – 728
    Helixi73 – 753
    Helixi82 – 9514
    Beta strandi100 – 1089
    Helixi109 – 12012
    Beta strandi124 – 1307
    Helixi131 – 1344
    Helixi138 – 1469
    Beta strandi150 – 1545
    Helixi161 – 17515
    Turni176 – 1783
    Beta strandi179 – 1813
    Helixi192 – 21524
    Beta strandi220 – 2256
    Beta strandi227 – 2293
    Helixi230 – 2367
    Helixi237 – 2393
    Beta strandi245 – 25410
    Helixi257 – 2593
    Helixi265 – 2684
    Beta strandi270 – 2745
    Beta strandi277 – 2815
    Helixi297 – 2993
    Helixi306 – 3138
    Beta strandi316 – 3238
    Helixi324 – 33815
    Helixi344 – 35815
    Beta strandi365 – 3706
    Beta strandi372 – 3743
    Helixi375 – 3773
    Helixi378 – 3858

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V8ZX-ray2.21A/B/C/D1-388[»]
    1WDWX-ray3.00B/D/F/H/J/L1-385[»]
    ProteinModelPortaliQ8U093.
    SMRiQ8U093. Positions 1-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8U093.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpB family.Curated

    Phylogenomic databases

    eggNOGiCOG0133.
    HOGENOMiHOG000161710.
    KOiK01696.
    OMAiVHTLMNV.

    Family and domain databases

    HAMAPiMF_00133. Trp_synth_beta.
    InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00263. trpB. 1 hit.
    PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8U093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFGEFGGQY VPETLIEPLK ELEKAYKRFK DDEEFNRQLN YYLKTWAGRP    50
    TPLYYAKRLT EKIGGAKIYL KREDLVHGGA HKTNNAIGQA LLAKFMGKTR 100
    LIAETGAGQH GVATAMAGAL LGMKVDIYMG AEDVERQKMN VFRMKLLGAN 150
    VIPVNSGSRT LKDAINEALR DWVATFEYTH YLIGSVVGPH PYPTIVRDFQ 200
    SVIGREAKAQ ILEAEGQLPD VIVACVGGGS NAMGIFYPFV NDKKVKLVGV 250
    EAGGKGLESG KHSASLNAGQ VGVFHGMLSY FLQDEEGQIK PTHSIAPGLD 300
    YPGVGPEHAY LKKIQRAEYV TVTDEEALKA FHELSRTEGI IPALESAHAV 350
    AYAMKLAKEM SRDEIIIVNL SGRGDKDLDI VLKVSGNV 388
    Length:388
    Mass (Da):42,529
    Last modified:June 1, 2002 - v1
    Checksum:i62C811579520E04B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080770 Genomic DNA. Translation: BAC11855.1.
    AE009950 Genomic DNA. Translation: AAL81830.1.
    RefSeqiNP_579435.1. NC_003413.1.
    WP_011012852.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81830; AAL81830; PF1706.
    GeneIDi1469583.
    KEGGipfu:PF1706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080770 Genomic DNA. Translation: BAC11855.1 .
    AE009950 Genomic DNA. Translation: AAL81830.1 .
    RefSeqi NP_579435.1. NC_003413.1.
    WP_011012852.1. NC_003413.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V8Z X-ray 2.21 A/B/C/D 1-388 [» ]
    1WDW X-ray 3.00 B/D/F/H/J/L 1-385 [» ]
    ProteinModelPortali Q8U093.
    SMRi Q8U093. Positions 1-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF1706.

    Proteomic databases

    PRIDEi Q8U093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81830 ; AAL81830 ; PF1706 .
    GeneIDi 1469583.
    KEGGi pfu:PF1706.

    Phylogenomic databases

    eggNOGi COG0133.
    HOGENOMi HOG000161710.
    KOi K01696.
    OMAi VHTLMNV.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .

    Miscellaneous databases

    EvolutionaryTracei Q8U093.

    Family and domain databases

    HAMAPi MF_00133. Trp_synth_beta.
    InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00263. trpB. 1 hit.
    PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression in Escherichia coli of the AT-rich trpA and trpB genes from the hyperthermophilic archaeon Pyrococcus furiosus."
      Ishida M., Oshima T., Yutani K.
      FEMS Microbiol. Lett. 216:179-183(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
    2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiTRPB1_PYRFU
    AccessioniPrimary (citable) accession number: Q8U093
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3