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Q8U093

- TRPB1_PYRFU

UniProt

Q8U093 - TRPB1_PYRFU

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Protein

Tryptophan synthase beta chain 1

Gene

trpB1

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 1 (EC:4.2.1.20)
Gene namesi
Name:trpB1
Ordered Locus Names:PF1706
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Tryptophan synthase beta chain 1PRO_0000099050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ8U093.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi186497.PF1706.

Structurei

Secondary structure

1
388
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 153
Helixi16 – 3015
Helixi33 – 4513
Beta strandi53 – 553
Helixi57 – 637
Beta strandi65 – 728
Helixi73 – 753
Helixi82 – 9514
Beta strandi100 – 1089
Helixi109 – 12012
Beta strandi124 – 1307
Helixi131 – 1344
Helixi138 – 1469
Beta strandi150 – 1545
Helixi161 – 17515
Turni176 – 1783
Beta strandi179 – 1813
Helixi192 – 21524
Beta strandi220 – 2256
Beta strandi227 – 2293
Helixi230 – 2367
Helixi237 – 2393
Beta strandi245 – 25410
Helixi257 – 2593
Helixi265 – 2684
Beta strandi270 – 2745
Beta strandi277 – 2815
Helixi297 – 2993
Helixi306 – 3138
Beta strandi316 – 3238
Helixi324 – 33815
Helixi344 – 35815
Beta strandi365 – 3706
Beta strandi372 – 3743
Helixi375 – 3773
Helixi378 – 3858

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V8ZX-ray2.21A/B/C/D1-388[»]
1WDWX-ray3.00B/D/F/H/J/L1-385[»]
ProteinModelPortaliQ8U093.
SMRiQ8U093. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U093.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiCOG0133.
HOGENOMiHOG000161710.
KOiK01696.
OMAiVHTLMNV.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U093-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFGEFGGQY VPETLIEPLK ELEKAYKRFK DDEEFNRQLN YYLKTWAGRP
60 70 80 90 100
TPLYYAKRLT EKIGGAKIYL KREDLVHGGA HKTNNAIGQA LLAKFMGKTR
110 120 130 140 150
LIAETGAGQH GVATAMAGAL LGMKVDIYMG AEDVERQKMN VFRMKLLGAN
160 170 180 190 200
VIPVNSGSRT LKDAINEALR DWVATFEYTH YLIGSVVGPH PYPTIVRDFQ
210 220 230 240 250
SVIGREAKAQ ILEAEGQLPD VIVACVGGGS NAMGIFYPFV NDKKVKLVGV
260 270 280 290 300
EAGGKGLESG KHSASLNAGQ VGVFHGMLSY FLQDEEGQIK PTHSIAPGLD
310 320 330 340 350
YPGVGPEHAY LKKIQRAEYV TVTDEEALKA FHELSRTEGI IPALESAHAV
360 370 380
AYAMKLAKEM SRDEIIIVNL SGRGDKDLDI VLKVSGNV
Length:388
Mass (Da):42,529
Last modified:June 1, 2002 - v1
Checksum:i62C811579520E04B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080770 Genomic DNA. Translation: BAC11855.1.
AE009950 Genomic DNA. Translation: AAL81830.1.
RefSeqiNP_579435.1. NC_003413.1.
WP_011012852.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81830; AAL81830; PF1706.
GeneIDi1469583.
KEGGipfu:PF1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080770 Genomic DNA. Translation: BAC11855.1 .
AE009950 Genomic DNA. Translation: AAL81830.1 .
RefSeqi NP_579435.1. NC_003413.1.
WP_011012852.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1V8Z X-ray 2.21 A/B/C/D 1-388 [» ]
1WDW X-ray 3.00 B/D/F/H/J/L 1-385 [» ]
ProteinModelPortali Q8U093.
SMRi Q8U093. Positions 1-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1706.

Proteomic databases

PRIDEi Q8U093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL81830 ; AAL81830 ; PF1706 .
GeneIDi 1469583.
KEGGi pfu:PF1706.

Phylogenomic databases

eggNOGi COG0133.
HOGENOMi HOG000161710.
KOi K01696.
OMAi VHTLMNV.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .

Miscellaneous databases

EvolutionaryTracei Q8U093.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overexpression in Escherichia coli of the AT-rich trpA and trpB genes from the hyperthermophilic archaeon Pyrococcus furiosus."
    Ishida M., Oshima T., Yutani K.
    FEMS Microbiol. Lett. 216:179-183(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-10.
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiTRPB1_PYRFU
AccessioniPrimary (citable) accession number: Q8U093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3