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Q8U092

- TRPF_PYRFU

UniProt

Q8U092 - TRPF_PYRFU

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:PF1707
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154412Add
BLAST

Proteomic databases

PRIDEiQ8U092.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1707.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54Combined sources
Helixi11 – 188Combined sources
Beta strandi22 – 276Combined sources
Beta strandi29 – 324Combined sources
Helixi38 – 4710Combined sources
Beta strandi52 – 565Combined sources
Helixi61 – 7111Combined sources
Beta strandi74 – 785Combined sources
Helixi84 – 9411Combined sources
Beta strandi97 – 1037Combined sources
Helixi111 – 12414Combined sources
Beta strandi128 – 1336Combined sources
Helixi145 – 1539Combined sources
Beta strandi156 – 1616Combined sources
Turni164 – 1663Combined sources
Helixi167 – 1748Combined sources
Beta strandi177 – 1826Combined sources
Helixi183 – 1853Combined sources
Helixi193 – 20513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AAJX-ray1.75A1-208[»]
ProteinModelPortaliQ8U092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
KOiK01817.
OMAiHDHRISQ.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVKICGIKS LEELEIVEKH ADATGVVVNS NSKRRIPLEK AREIIENSAI
60 70 80 90 100
PVFLVSTMVG FSEWAMAIER TGAQYIQVHS NALPQTIDTL KKEFGVFVMK
110 120 130 140 150
AFRVPTISKN PEEDANRLLS EISRYNADMV LLDTGAGSGK LHDLRVSSLV
160 170 180 190 200
ARKIPVIVAG GLNAENVEEV IKVVKPYGVD VSSGVEKYGI KDPKLVEEFV

RRAKNVVW
Length:208
Mass (Da):22,994
Last modified:June 1, 2002 - v1
Checksum:i2A00EE4E9FDB7495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81831.1.
RefSeqiNP_579436.1. NC_003413.1.
WP_011012853.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81831; AAL81831; PF1707.
GeneIDi1469584.
KEGGipfu:PF1707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81831.1 .
RefSeqi NP_579436.1. NC_003413.1.
WP_011012853.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AAJ X-ray 1.75 A 1-208 [» ]
ProteinModelPortali Q8U092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1707.

Proteomic databases

PRIDEi Q8U092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL81831 ; AAL81831 ; PF1707 .
GeneIDi 1469584.
KEGGi pfu:PF1707.

Phylogenomic databases

eggNOGi COG0135.
HOGENOMi HOG000161598.
KOi K01817.
OMAi HDHRISQ.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiTRPF_PYRFU
AccessioniPrimary (citable) accession number: Q8U092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3