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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 2 (trpB2), Tryptophan synthase beta chain 1 (trpB1)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BRENDAi5.3.1.24. 5243.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:PF1707
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001544121 – 208N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST208

Proteomic databases

PRIDEiQ8U092.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1707.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Helixi11 – 18Combined sources8
Beta strandi22 – 27Combined sources6
Beta strandi29 – 32Combined sources4
Helixi38 – 47Combined sources10
Beta strandi52 – 56Combined sources5
Helixi61 – 71Combined sources11
Beta strandi74 – 78Combined sources5
Helixi84 – 94Combined sources11
Beta strandi97 – 103Combined sources7
Helixi111 – 124Combined sources14
Beta strandi128 – 133Combined sources6
Helixi145 – 153Combined sources9
Beta strandi156 – 161Combined sources6
Turni164 – 166Combined sources3
Helixi167 – 174Combined sources8
Beta strandi177 – 182Combined sources6
Helixi183 – 185Combined sources3
Helixi193 – 205Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AAJX-ray1.75A1-208[»]
ProteinModelPortaliQ8U092.
SMRiQ8U092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01983. Archaea.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiHDHRISQ.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVKICGIKS LEELEIVEKH ADATGVVVNS NSKRRIPLEK AREIIENSAI
60 70 80 90 100
PVFLVSTMVG FSEWAMAIER TGAQYIQVHS NALPQTIDTL KKEFGVFVMK
110 120 130 140 150
AFRVPTISKN PEEDANRLLS EISRYNADMV LLDTGAGSGK LHDLRVSSLV
160 170 180 190 200
ARKIPVIVAG GLNAENVEEV IKVVKPYGVD VSSGVEKYGI KDPKLVEEFV

RRAKNVVW
Length:208
Mass (Da):22,994
Last modified:June 1, 2002 - v1
Checksum:i2A00EE4E9FDB7495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81831.1.
RefSeqiWP_011012853.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81831; AAL81831; PF1707.
GeneIDi1469584.
KEGGipfu:PF1707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81831.1.
RefSeqiWP_011012853.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AAJX-ray1.75A1-208[»]
ProteinModelPortaliQ8U092.
SMRiQ8U092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1707.

Proteomic databases

PRIDEiQ8U092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81831; AAL81831; PF1707.
GeneIDi1469584.
KEGGipfu:PF1707.

Phylogenomic databases

eggNOGiarCOG01983. Archaea.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiHDHRISQ.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
BRENDAi5.3.1.24. 5243.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPF_PYRFU
AccessioniPrimary (citable) accession number: Q8U092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.