Q8U088 (TRPC_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	PF1711

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_0000154299

Sequences

	Sequence		Length	Mass (Da)
	Q8U088 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 04D1ADCAF187ADA9	FASTA	228	25,308
	10 20 30 40 50 60 MVIFGLSRAI RKAKKNPIIA EIKVYSPKYG DLLRGRDPLR ILRAYEEAGA VGISYITDQK 70 80 90 100 110 120 YFKGSFDFLK VLCKETTLPV LRKDFITSKE EIEKTAEVGA SAVLLITRIL KDKLPEFVDY 130 140 150 160 170 180 AKEHGLDTLV EVHTEDELKL AIKTNSTMIG INNRDIGKLE MDDGDVSLTE ILAPKIPGKF 190 200 210 220 VKVSESGIAT LEDLKRALRV ADAALIGTAL MKAENPAELL KKFVEAEI

References

[1]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81835.1.
RefSeq	NP_579440.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8U088.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000006048; EBPYRP00000005909; EBPYRG00000006047.
GeneID	1469588.
GenomeReviews	Gene locus PF1711 in contig AE009950_GR.
KEGG	pfu:PF1711.
NMPDR	fig|186497.1.peg.1759.
Phylogenomic databases
GeneTree	EBGT00050000022896.
HOGENOM	HBG540956.
OMA	FFPEQVK.
PhylomeDB	Q8U088.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PYRFU

Accession

Primary (citable) accession number: Q8U088

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program