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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPUniRule annotation8
Nucleotide bindingi90 – 94GTPUniRule annotation5
Nucleotide bindingi146 – 149GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:PF1717
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374601 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Proteomic databases

PRIDEiQ8U082.

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

DIPiDIP-54412N.
IntActiQ8U082. 1 interactor.
STRINGi186497.PF1717.

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 18Combined sources6
Turni20 – 23Combined sources4
Helixi24 – 32Combined sources9
Helixi33 – 35Combined sources3
Beta strandi47 – 49Combined sources3
Beta strandi52 – 61Combined sources10
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi74 – 76Combined sources3
Beta strandi79 – 90Combined sources12
Helixi94 – 103Combined sources10
Turni104 – 106Combined sources3
Beta strandi109 – 116Combined sources8
Helixi124 – 135Combined sources12
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Helixi153 – 167Combined sources15
Turni171 – 174Combined sources4
Beta strandi177 – 181Combined sources5
Turni182 – 185Combined sources4
Helixi188 – 197Combined sources10
Beta strandi211 – 218Combined sources8
Beta strandi234 – 242Combined sources9
Beta strandi249 – 254Combined sources6
Beta strandi260 – 264Combined sources5
Beta strandi270 – 278Combined sources9
Beta strandi279 – 282Combined sources4
Beta strandi284 – 286Combined sources3
Beta strandi288 – 290Combined sources3
Beta strandi292 – 298Combined sources7
Helixi300 – 303Combined sources4
Helixi304 – 306Combined sources3
Beta strandi312 – 315Combined sources4
Beta strandi322 – 328Combined sources7
Helixi340 – 343Combined sources4
Beta strandi353 – 358Combined sources6
Beta strandi361 – 370Combined sources10
Beta strandi375 – 384Combined sources10
Beta strandi390 – 395Combined sources6
Beta strandi402 – 409Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortaliQ8U082.
SMRiQ8U082.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U082.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 203tr-type GAdd BLAST195

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKTRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CSNCGRYSTS PICPYCGHET EFIRRVSFID SPGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIKGT VAENAPIIPI SALHGANIDV LVKAIEEFIP
210 220 230 240 250
TPKRDSNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGIGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWTDLRLEV HLLERVVGTE QELNVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTAL GKDEIELKLQ IPVCAEPGER VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):45,038
Last modified:June 1, 2002 - v1
Checksum:i377B25EC26B2D88C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81841.1.
RefSeqiWP_011012863.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81841; AAL81841; PF1717.
GeneIDi1469594.
KEGGipfu:PF1717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81841.1.
RefSeqiWP_011012863.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortaliQ8U082.
SMRiQ8U082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-54412N.
IntActiQ8U082. 1 interactor.
STRINGi186497.PF1717.

Proteomic databases

PRIDEiQ8U082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81841; AAL81841; PF1717.
GeneIDi1469594.
KEGGipfu:PF1717.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiWTDRHSE.

Miscellaneous databases

EvolutionaryTraceiQ8U082.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_PYRFU
AccessioniPrimary (citable) accession number: Q8U082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.