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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPUniRule annotation8
Nucleotide bindingi90 – 94GTPUniRule annotation5
Nucleotide bindingi146 – 149GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:PF1717
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374601 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Proteomic databases

PRIDEiQ8U082

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
eif2bQ8U3I52EBI-2504997,EBI-2505077

Protein-protein interaction databases

DIPiDIP-54412N
IntActiQ8U082, 2 interactors
STRINGi186497.PF1717

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 18Combined sources6
Turni20 – 23Combined sources4
Helixi24 – 32Combined sources9
Helixi33 – 35Combined sources3
Beta strandi47 – 49Combined sources3
Beta strandi52 – 61Combined sources10
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi74 – 76Combined sources3
Beta strandi79 – 90Combined sources12
Helixi94 – 103Combined sources10
Turni104 – 106Combined sources3
Beta strandi109 – 116Combined sources8
Helixi124 – 135Combined sources12
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Helixi153 – 167Combined sources15
Turni171 – 174Combined sources4
Beta strandi177 – 181Combined sources5
Turni182 – 185Combined sources4
Helixi188 – 197Combined sources10
Beta strandi211 – 218Combined sources8
Beta strandi234 – 242Combined sources9
Beta strandi249 – 254Combined sources6
Beta strandi260 – 264Combined sources5
Beta strandi270 – 278Combined sources9
Beta strandi279 – 282Combined sources4
Beta strandi284 – 286Combined sources3
Beta strandi288 – 290Combined sources3
Beta strandi292 – 298Combined sources7
Helixi300 – 303Combined sources4
Helixi304 – 306Combined sources3
Beta strandi312 – 315Combined sources4
Beta strandi322 – 328Combined sources7
Helixi340 – 343Combined sources4
Beta strandi353 – 358Combined sources6
Beta strandi361 – 370Combined sources10
Beta strandi375 – 384Combined sources10
Beta strandi390 – 395Combined sources6
Beta strandi402 – 409Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortaliQ8U082
SMRiQ8U082
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U082

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 203tr-type GAdd BLAST195

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01563 Archaea
COG5257 LUCA
HOGENOMiHOG000229292
KOiK03242
OMAiCPQPQTK
OrthoDBiPOG093Z03P8

Family and domain databases

CDDicd15490 eIF2_gamma_III, 1 hit
HAMAPiMF_00119 eIF_2_gamma, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR022424 TIF2_gsu
IPR015256 TIF2_gsu_C
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173 eIF2_C, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03680 eif2g_arch, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKTRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CSNCGRYSTS PICPYCGHET EFIRRVSFID SPGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIKGT VAENAPIIPI SALHGANIDV LVKAIEEFIP
210 220 230 240 250
TPKRDSNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGIGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWTDLRLEV HLLERVVGTE QELNVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTAL GKDEIELKLQ IPVCAEPGER VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):45,038
Last modified:June 1, 2002 - v1
Checksum:i377B25EC26B2D88C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81841.1
RefSeqiWP_011012863.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81841; AAL81841; PF1717
GeneIDi1469594
KEGGipfu:PF1717
PATRICifig|186497.12.peg.1785

Similar proteinsi

Entry informationi

Entry nameiIF2G_PYRFU
AccessioniPrimary (citable) accession number: Q8U082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health