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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPUniRule annotation
Nucleotide bindingi90 – 945GTPUniRule annotation
Nucleotide bindingi146 – 1494GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:PF1717
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Translation initiation factor 2 subunit gammaPRO_0000137460Add
BLAST

Proteomic databases

PRIDEiQ8U082.

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

DIPiDIP-54412N.
IntActiQ8U082. 1 interaction.
STRINGi186497.PF1717.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 186Combined sources
Turni20 – 234Combined sources
Helixi24 – 329Combined sources
Helixi33 – 353Combined sources
Beta strandi47 – 493Combined sources
Beta strandi52 – 6110Combined sources
Turni62 – 643Combined sources
Beta strandi67 – 726Combined sources
Beta strandi74 – 763Combined sources
Beta strandi79 – 9012Combined sources
Helixi94 – 10310Combined sources
Turni104 – 1063Combined sources
Beta strandi109 – 1168Combined sources
Helixi124 – 13512Combined sources
Beta strandi141 – 1466Combined sources
Helixi148 – 1503Combined sources
Helixi153 – 16715Combined sources
Turni171 – 1744Combined sources
Beta strandi177 – 1815Combined sources
Turni182 – 1854Combined sources
Helixi188 – 19710Combined sources
Beta strandi211 – 2188Combined sources
Beta strandi234 – 2429Combined sources
Beta strandi249 – 2546Combined sources
Beta strandi260 – 2645Combined sources
Beta strandi270 – 2789Combined sources
Beta strandi279 – 2824Combined sources
Beta strandi284 – 2863Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi292 – 2987Combined sources
Helixi300 – 3034Combined sources
Helixi304 – 3063Combined sources
Beta strandi312 – 3154Combined sources
Beta strandi322 – 3287Combined sources
Helixi340 – 3434Combined sources
Beta strandi353 – 3586Combined sources
Beta strandi361 – 37010Combined sources
Beta strandi375 – 38410Combined sources
Beta strandi390 – 3956Combined sources
Beta strandi402 – 4098Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortaliQ8U082.
SMRiQ8U082. Positions 6-411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U082.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 203195tr-type GAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiIAANEPC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKRKTRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK
60 70 80 90 100
IGFADAEIRR CSNCGRYSTS PICPYCGHET EFIRRVSFID SPGHEALMTT
110 120 130 140 150
MLAGASLMDG AILVIAANEP CPRPQTREHL MALQIIGQKN IIIAQNKIEL
160 170 180 190 200
VDKEKALENY RQIKEFIKGT VAENAPIIPI SALHGANIDV LVKAIEEFIP
210 220 230 240 250
TPKRDSNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV QGKLKVGDEI
260 270 280 290 300
EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGIGTKLDP
310 320 330 340 350
YLTKGDLMAG NVVGKPGKLP PVWTDLRLEV HLLERVVGTE QELNVEPIKR
360 370 380 390 400
KEVLLLNVGT ARTMGLVTAL GKDEIELKLQ IPVCAEPGER VAISRQIGSR
410
WRLIGYGIIK E
Length:411
Mass (Da):45,038
Last modified:June 1, 2002 - v1
Checksum:i377B25EC26B2D88C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81841.1.
RefSeqiWP_011012863.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81841; AAL81841; PF1717.
GeneIDi1469594.
KEGGipfu:PF1717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81841.1.
RefSeqiWP_011012863.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortaliQ8U082.
SMRiQ8U082. Positions 6-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-54412N.
IntActiQ8U082. 1 interaction.
STRINGi186497.PF1717.

Proteomic databases

PRIDEiQ8U082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81841; AAL81841; PF1717.
GeneIDi1469594.
KEGGipfu:PF1717.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
KOiK03242.
OMAiIAANEPC.

Miscellaneous databases

EvolutionaryTraceiQ8U082.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiIF2G_PYRFU
AccessioniPrimary (citable) accession number: Q8U082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.