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Q8U082 (IF2G_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene names
Name:eif2g
Ordered Locus Names:PF1717
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus ›

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00119

Subunit structure

Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EIF2G subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Translation initiation factor 2 subunit gamma HAMAP-Rule MF_00119
PRO_0000137460

Regions

Nucleotide binding18 – 258GTP By similarity
Nucleotide binding90 – 945GTP By similarity
Nucleotide binding146 – 1494GTP By similarity

Secondary structure

1 .......................................................................... 411
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8U082 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 377B25EC26B2D88C

FASTA41145,038
        10         20         30         40         50         60 
MGEKRKTRQA EVNIGMVGHV DHGKTTLTKA LTGVWTDTHS EELRRGITIK IGFADAEIRR 

        70         80         90        100        110        120 
CSNCGRYSTS PICPYCGHET EFIRRVSFID SPGHEALMTT MLAGASLMDG AILVIAANEP 

       130        140        150        160        170        180 
CPRPQTREHL MALQIIGQKN IIIAQNKIEL VDKEKALENY RQIKEFIKGT VAENAPIIPI 

       190        200        210        220        230        240 
SALHGANIDV LVKAIEEFIP TPKRDSNKPP KMLVLRSFDV NKPGTPPEKL VGGVLGGSIV 

       250        260        270        280        290        300 
QGKLKVGDEI EIRPGVPYEE HGRIKYEPIT TEIVSLQAGG QFVEEAYPGG LVGIGTKLDP 

       310        320        330        340        350        360 
YLTKGDLMAG NVVGKPGKLP PVWTDLRLEV HLLERVVGTE QELNVEPIKR KEVLLLNVGT 

       370        380        390        400        410 
ARTMGLVTAL GKDEIELKLQ IPVCAEPGER VAISRQIGSR WRLIGYGIIK E

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References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009950 Genomic DNA. Translation: AAL81841.1.
RefSeqNP_579446.1. NC_003413.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D74X-ray2.80A1-411[»]
2DCUX-ray3.40A1-411[»]
ProteinModelPortalQ8U082.
SMRQ8U082. Positions 6-411.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8U082. 1 interaction.
STRING186497.PF1717.

Proteomic databases

PRIDEQ8U082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL81841; AAL81841; PF1717.
GeneID1469594.
KEGGpfu:PF1717.

Phylogenomic databases

eggNOGCOG5257.
HOGENOMHOG000229292.
KOK03242.
OMAIAANEPC.
ProtClustDBPRK04000.

Family and domain databases

HAMAPMF_00119. eIF-2-gamma.
InterProIPR000795. EF_GTP-bd_dom.
IPR005225. Small_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PfamPF09173. eIF2_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50465. Elong_init_C. 1 hit.
SSF50447. Translat_factor. 1 hit.
TIGRFAMsTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8U082.

Entry information

Entry nameIF2G_PYRFU
AccessionPrimary (citable) accession number: Q8U082
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Translation initiation factors

List of translation initiation factor entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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