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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:PF1730
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553941 – 210Probable thymidylate kinaseAdd BLAST210

Proteomic databases

PRIDEiQ8U071.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1730.

Structurei

3D structure databases

ProteinModelPortaliQ8U071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiSSLAYQW.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRGLFIVLE GIDGSGKTTQ ARLLARWFED NGFKVVLTKE PTDTEFGKII
60 70 80 90 100
RKLVLEGSII DGGRISLEAE ALLFAADRAE HVKKIIEPAL REGKVVISDR
110 120 130 140 150
YFYSSLAYQW ARGLNLEWLI EINKFAPHPD IAILLDIPPR EGIKRIKKRS
160 170 180 190 200
SQTEFDKLFK LQEKVRENYI KLAKMFDEIK IIDATKSVEE VHREIISSIK
210
EIWGKNYGSR
Length:210
Mass (Da):24,160
Last modified:June 1, 2002 - v1
Checksum:i8001D406A19BEB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81854.1.
RefSeqiWP_011012876.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81854; AAL81854; PF1730.
GeneIDi1469607.
KEGGipfu:PF1730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81854.1.
RefSeqiWP_011012876.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8U071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1730.

Proteomic databases

PRIDEiQ8U071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81854; AAL81854; PF1730.
GeneIDi1469607.
KEGGipfu:PF1730.

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiSSLAYQW.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_PYRFU
AccessioniPrimary (citable) accession number: Q8U071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.