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Protein

Signal recognition particle receptor FtsY

Gene

ftsY

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 1378GTPUniRule annotation
Nucleotide bindingi212 – 2165GTPUniRule annotation
Nucleotide bindingi270 – 2734GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.4. 5243.

Protein family/group databases

TCDBi3.A.5.7.2. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor FtsYUniRule annotation
Short name:
SRP receptorUniRule annotation
Gene namesi
Name:ftsYUniRule annotation
Ordered Locus Names:PF1766Imported
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8U051.

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1766.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DM9X-ray2.20B1-322[»]
3DMDX-ray2.21A/B/C1-322[»]
3E70X-ray1.97C1-322[»]
ProteinModelPortaliQ8U051.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8U051.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini291 – 30414SRP54InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili6 – 3530Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GTP-binding SRP family. FtsY subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01227. Archaea.
COG0552. LUCA.
HOGENOMiHOG000036277.
KOiK03110.
OMAiKPTVIVF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00920. FtsY.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00064. ftsY. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8U051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGKLREKLK SFVKRVEEEV EKEEEEVEKK GLLDRILTVE IKEKDVDKAL
60 70 80 90 100
DELEIDLLEA DVALEVVDAL REKIKQKLVG KKVRIGTDKG KIIEEAVKEA
110 120 130 140 150
VSEILETSRR IDLIEEIRKA EKPYVIMFVG FNGSGKTTTI AKLANWLKNH
160 170 180 190 200
GFSVVIAASD TFRAGAIEQL EEHAKRIGVK VIKHSYGADP AAVAYDAIQH
210 220 230 240 250
AKARGIDVVL IDTAGRSETN RNLMDEMKKI ARVTKPNLVI FVGDALAGNA
260 270 280 290 300
IVEQARQFNE AVKIDGIILT KLDADARGGA ALSISYVIDA PILFVGVGQG
310 320
YDDLRPFEKE WFLERIFGEE NA
Length:322
Mass (Da):35,813
Last modified:June 1, 2002 - v1
Checksum:i7D6039DD9A688E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81890.1.
RefSeqiWP_011012907.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81890; AAL81890; PF1766.
GeneIDi1469645.
KEGGipfu:PF1766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81890.1.
RefSeqiWP_011012907.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DM9X-ray2.20B1-322[»]
3DMDX-ray2.21A/B/C1-322[»]
3E70X-ray1.97C1-322[»]
ProteinModelPortaliQ8U051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1766.

Protein family/group databases

TCDBi3.A.5.7.2. the general secretory pathway (sec) family.

Proteomic databases

PRIDEiQ8U051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81890; AAL81890; PF1766.
GeneIDi1469645.
KEGGipfu:PF1766.

Phylogenomic databases

eggNOGiarCOG01227. Archaea.
COG0552. LUCA.
HOGENOMiHOG000036277.
KOiK03110.
OMAiKPTVIVF.

Enzyme and pathway databases

BRENDAi3.6.5.4. 5243.

Miscellaneous databases

EvolutionaryTraceiQ8U051.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00920. FtsY.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00064. ftsY. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1Imported.
  2. "Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane."
    Egea P.F., Tsuruta H., de Leon G.P., Napetschnig J., Walter P., Stroud R.M.
    PLoS ONE 3:e3619-e3619(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS).

Entry informationi

Entry nameiQ8U051_PYRFU
AccessioniPrimary (citable) accession number: Q8U051
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: December 9, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.