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Protein

50S ribosomal protein L5

Gene

rpl5

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5UniRule annotation
Gene namesi
Name:rpl5UniRule annotation
Ordered Locus Names:PF1811
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001250651 – 18650S ribosomal protein L5Add BLAST186

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1811.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4Nelectron microscopy9.00E1-186[»]
4V6Uelectron microscopy6.60BE1-186[»]
ProteinModelPortaliQ8U012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04092. Archaea.
COG0094. LUCA.
HOGENOMiHOG000231312.
KOiK02931.
OMAiEHTEFPS.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_A. Ribosomal_L5_A. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR022804. Ribosomal_L5_arc.
IPR031309. Ribosomal_L5_C.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8U012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEIPNKEQ ILADWEAHPM RRPRIEKVTI NIGVGESGER LTKAEIMLQQ
60 70 80 90 100
LTGQKPIRRK AKKTNRDFGI RRGEPIAVKV TLRGPKAYEL LKRLLAAVDN
110 120 130 140 150
RLKASSFDEH GNVCFGIEEH INIPGVEYDP EIGIFGMDVC VTLERPGFRV
160 170 180
ARRKRKRAKI PTRHKLTKEE GMVYMMEEFG VEIVEG
Length:186
Mass (Da):21,231
Last modified:June 1, 2002 - v1
Checksum:i611DBD95C98F5E20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81935.1.
RefSeqiWP_011012952.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81935; AAL81935; PF1811.
GeneIDi1469690.
KEGGipfu:PF1811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81935.1.
RefSeqiWP_011012952.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4Nelectron microscopy9.00E1-186[»]
4V6Uelectron microscopy6.60BE1-186[»]
ProteinModelPortaliQ8U012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81935; AAL81935; PF1811.
GeneIDi1469690.
KEGGipfu:PF1811.

Phylogenomic databases

eggNOGiarCOG04092. Archaea.
COG0094. LUCA.
HOGENOMiHOG000231312.
KOiK02931.
OMAiEHTEFPS.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_A. Ribosomal_L5_A. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR022804. Ribosomal_L5_arc.
IPR031309. Ribosomal_L5_C.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_PYRFU
AccessioniPrimary (citable) accession number: Q8U012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.