Reviewed, UniProtKB/Swiss-Prot Q8U007 (RNP1_PYRFU)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 1
      Short name=RNase P component 1
    EC=3.1.26.5

Gene names

Name:	rnp1
Ordered Locus Names:	PF1816

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00754
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Cellular component	ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro ribonuclease P complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Ribonuclease P protein component 1 HAMAP MF_00754		PRO_0000128436

Sequences

	Sequence		Length	Mass (Da)
	Q8U007-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3CBBA84DD7AE7E4C	FASTA	127	14,953
	10 20 30 40 50 60 MWRNSEEREN RTSGRSQGSY QEIIGRTWIF RGAHRGRVNK KNIVWHELIG LKVRVVNSTH 70 80 90 100 110 120 PGYVGIEGYV IDETRNMLVI AGENKVWKVP KDVCIFEFET WDGTKIKISG EKLVGRPEMR LKKRWRK

References

[1]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE009950 Genomic DNA. Translation: AAL81940.1.

RefSeq

NP_579545.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KI7	NMR	-	A	1-127	[»]

SMR

Q8U007. Positions 36-127.

ModBase

Search...

Genome annotation databases

GeneID

1469695.

GenomeReviews

Gene locus PF1816 in contig AE009950_GR.

KEGG

pfu:PF1816.

NMPDR

fig|186497.1.peg.1865.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

Q8U007.

OMA

VINETRN.

Enzyme and pathway databases

BRENDA

3.1.26.5. 321.

Family and domain databases

HAMAP

MF_00754.
[Tree]

InterPro

IPR002730. RNase_P/MRP_p29-sub_euk/arc.
[Graphical view]

Gene3D

G3DSA:2.30.30.210. RNase_P_Rpp29. 1 hit.

Pfam

PF01868. UPF0086. 1 hit.
[Graphical view]

ProDom

PD009163. UPF0086. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00538. POP4. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RNP1_PYRFU

Accession

Primary (citable) accession number: Q8U007

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)