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Protein

50S ribosomal protein L2

Gene

rpl2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2UniRule annotation
Alternative name(s):
Large ribosomal subunit protein uL2
Gene namesi
Name:rpl2UniRule annotation
Ordered Locus Names:PF1822
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001297231 – 23950S ribosomal protein L2Add BLAST239

Proteomic databases

PRIDEiQ8U001

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit (PubMed:23222135). Forms a bridge to the 30S subunit in the 70S ribosome.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi186497.PF1822

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V4Nelectron microscopy9.00B1-239[»]
4V6Uelectron microscopy6.60BB1-239[»]
ProteinModelPortaliQ8U001
SMRiQ8U001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04067 Archaea
COG0090 LUCA
HOGENOMiHOG000232983
KOiK02886
OMAiHGYIKGV
OrthoDBiPOG093Z08WO

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_A Ribosomal_L2_A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR023672 Ribosomal_L2_arc
IPR022669 Ribosomal_L2_C
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit

Sequencei

Sequence statusi: Complete.

Q8U001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSLIQQRR GKGSPTFKSP SHRFRGAVKY IPLNYTQEKT LRGVVEEIMH
60 70 80 90 100
DPGRTAPVAR VKFENGIEKL IIAPEGLLVG QEIYIGPDAP IAVGNTLPLA
110 120 130 140 150
KIPEGTYVYN IEGIPGDGGK YVRAGGTYAL VVSREPDKVI VQLPSGELKA
160 170 180 190 200
FNPMCRATIG VVAGGGRLEK PLVKAGKAYY KYKARNKFWP TPRGVKMNAV
210 220 230
NHPFGGKEHH PGKPTTTSRR APPGRKVGHI AARRTGRRK
Length:239
Mass (Da):26,037
Last modified:June 1, 2002 - v1
Checksum:iD260820A754EAFB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81946.1
RefSeqiWP_011012963.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81946; AAL81946; PF1822
GeneIDi1469701
KEGGipfu:PF1822
PATRICifig|186497.12.peg.1893

Similar proteinsi

Entry informationi

Entry nameiRL2_PYRFU
AccessioniPrimary (citable) accession number: Q8U001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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