Q8TZZ2 (MPTA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2

Gene names

Name:	mptA
Ordered Locus Names:	PF1832

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus furiosus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Pathway	Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	GTP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	GTP cyclohydrolase MptA HAMAP-Rule MF_01527		PRO_0000147750
Sites
	Site	157	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TZZ2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 47AA23BCEF2DE7BE	FASTA	267	30,509
	10 20 30 40 50 60 MTIETQEEPP EIKVYLPRVG ITNLKSVAKI EWKGRIYTFI PTFEVAIDLP EEKKGIHMSR 70 80 90 100 110 120 LVESITETMS EAVEEEVKKV HTSLEDLALC IIRRIEKKHS HKRAEVWIKS TLILERQTPA 130 140 150 160 170 180 SGKTSYEPYD VEVGVIKNSD GSIKKVLKVK VIGNTACPHA MANNQGKTHI QRAIAELEIE 190 200 210 220 230 240 THFNEDIALE DMIEVVESSF SSPTYTLLKT PDENAVVRRM YENPKFVEDV AREIVYKARN 250 260 RFKGKIHVKV ISHESIHKHD VIAEVWA

References

[1]

"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL81956.1.
RefSeq	NP_579561.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8TZZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	186497.PF1832.
Proteomic databases
PRIDE	Q8TZZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL81956; AAL81956; PF1832.
GeneID	1469711.
KEGG	pfu:PF1832.
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280680.
KO	K09007.
OMA	VEDCVRE.
ProtClustDB	PRK13675.
Enzyme and pathway databases
UniPathway	UPA00065.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_A. GTP_cyclohydrol_A.
InterPro	IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR022840. GTP_cyclohydrolase_MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPTA_PYRFU

Accession

Primary (citable) accession number: Q8TZZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program