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Protein

Chromosome partition protein Smc

Gene

smc

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for chromosome condensation and partitioning (By similarity). Binds single-stranded but not double-stranded DNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPUniRule annotation1 Publication8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein SmcUniRule annotation
Gene namesi
Name:smcUniRule annotation
Ordered Locus Names:PF1843
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092871 – 1177Chromosome partition protein SmcAdd BLAST1177

Interactioni

Subunit structurei

Homodimer.UniRule annotation2 Publications

Protein-protein interaction databases

DIPiDIP-54374N.
IntActiQ8TZY2. 2 interactors.
STRINGi186497.PF1843.

Structurei

Secondary structure

11177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 12Combined sources10
Helixi13 – 15Combined sources3
Beta strandi20 – 23Combined sources4
Beta strandi26 – 33Combined sources8
Helixi39 – 49Combined sources11
Helixi56 – 58Combined sources3
Helixi63 – 66Combined sources4
Beta strandi80 – 87Combined sources8
Beta strandi93 – 106Combined sources14
Beta strandi112 – 116Combined sources5
Beta strandi119 – 121Combined sources3
Helixi123 – 132Combined sources10
Helixi137 – 139Combined sources3
Helixi150 – 153Combined sources4
Helixi156 – 167Combined sources12
Helixi490 – 505Combined sources16
Helixi510 – 514Combined sources5
Beta strandi521 – 525Combined sources5
Helixi526 – 529Combined sources4
Beta strandi531 – 533Combined sources3
Helixi535 – 537Combined sources3
Helixi538 – 545Combined sources8
Helixi546 – 550Combined sources5
Beta strandi552 – 556Combined sources5
Helixi557 – 569Combined sources13
Beta strandi577 – 579Combined sources3
Turni580 – 582Combined sources3
Beta strandi592 – 595Combined sources4
Helixi596 – 599Combined sources4
Helixi604 – 606Combined sources3
Helixi607 – 614Combined sources8
Beta strandi617 – 621Combined sources5
Helixi624 – 629Combined sources6
Turni630 – 632Combined sources3
Beta strandi633 – 637Combined sources5
Turni638 – 640Combined sources3
Beta strandi649 – 651Combined sources3
Beta strandi659 – 661Combined sources3
Helixi663 – 713Combined sources51
Turni714 – 716Combined sources3
Helixi1008 – 1031Combined sources24
Beta strandi1036 – 1042Combined sources7
Beta strandi1044 – 1046Combined sources3
Helixi1047 – 1049Combined sources3
Beta strandi1052 – 1057Combined sources6
Beta strandi1060 – 1062Combined sources3
Helixi1066 – 1068Combined sources3
Helixi1071 – 1088Combined sources18
Beta strandi1092 – 1098Combined sources7
Turni1099 – 1102Combined sources4
Helixi1105 – 1118Combined sources14
Turni1119 – 1121Combined sources3
Beta strandi1122 – 1127Combined sources6
Helixi1131 – 1134Combined sources4
Beta strandi1138 – 1146Combined sources9
Beta strandi1149 – 1154Combined sources6
Helixi1157 – 1168Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEWX-ray2.00X1-182[»]
Y1006-1177[»]
1XEXX-ray2.50A1-182[»]
3KTAX-ray1.63A/C1-182[»]
B/D1006-1177[»]
3NWCX-ray1.70A/B488-667[»]
4I99X-ray2.30A/B1-1172[»]
4RSJX-ray3.50A/B/C/D445-720[»]
ProteinModelPortaliQ8TZY2.
SMRiQ8TZY2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TZY2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili167 – 506UniRule annotationAdd BLAST340
Coiled coili659 – 1012UniRule annotationAdd BLAST354

Domaini

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures. The N- and C-terminus interact to make up an ATP-binding cassette-type ATPase domain. The hinge domain mediates dimerization and binds DNA.UniRule annotation2 Publications

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiarCOG00371. Archaea.
COG1196. LUCA.
HOGENOMiHOG000228754.
KOiK03529.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
HAMAPiMF_01894. Smc_prok. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsiTIGR02169. SMC_prok_A. 1 hit.
TIGR02168. SMC_prok_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TZY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYIEKLELK GFKSYGNKKV VIPFSKGFTA IVGANGSGKS NIGDAILFVL
60 70 80 90 100
GGLSAKAMRA SRISDLIFAG SKNEPPAKYA EVAIYFNNED RGFPIDEDEV
110 120 130 140 150
VIRRRVYPDG RSSYWLNGRR ATRSEILDIL TAAMISPDGY NIVLQGDITK
160 170 180 190 200
FIKMSPLERR LLIDDISGIA EYDSKKEKAL EELKQAEENL ARVDLLIKEV
210 220 230 240 250
KKQLDKLEKE RNDALRYLDL KDKLEKAKVS LLLGEIKILE TQIKEGEKRR
260 270 280 290 300
AEIEEEIQKI EKEIEKIGKE IVEKVKVLRE IEERIEKESG EEAIQITKKI
310 320 330 340 350
GEVTSKIELT KRNIEVAKEE LEDAQRRLAK TKEELRKVLS EIEKSKGAIT
360 370 380 390 400
RWKKRRDALI NEIKKKEEER NVLVVKLGEI DKTFGAAREE FDSVVKELEE
410 420 430 440 450
TTRKMYEIEG NIRRLQEEKE KLHSRILFLR AKLPGIKEKI NEFKAVVEDK
460 470 480 490 500
RAEISEIEGK LSTIQAKRIK VEKEIEAKSN ELEKVSKELE SSERELIAAE
510 520 530 540 550
AQREVRGNRA AEELKRSGIG GIYGTLAELI KVKDEAYALA IEVALGNRAD
560 570 580 590 600
NVVVEDELVA EKAIKYLKEH KLGRLTFLPL NKIKPKHVDS SVGLPAVDVI
610 620 630 640 650
EYDQKIENAV KFALGDTVIV NSMEEARPHI GKVRMVTIEG ELYERSGAIT
660 670 680 690 700
GGHFRARGLA VDTTKLREKV ESLRRRKEAL EGELNSLKIE LRSLENASFE
710 720 730 740 750
LRIKLSDEKK ELELASKDLN RLLEEENAVK EEIEESERKI QEIEQKIENE
760 770 780 790 800
KSELAKLRGR IQRLERKKEK LKKALENPEA RELMEKIRII DGEISSLKEE
810 820 830 840 850
LSRIESRIES LESRLNEELL PRKASLEEEI EGLVNKINAL KNNISENEKA
860 870 880 890 900
LELLNKELEK LKSIEENIKG EIRTLREKRK KLEEDISKLR EKKEVLQRKL
910 920 930 940 950
QELEIEANTL KVRDAQLNAQ LEEKKYQLTH YDKNLIKSIK EIPLDLEKVK
960 970 980 990 1000
KEIEKMEEEI RSLEPVNMKA IEDFEIVERR YLELKSKREK LEAEKESIIE
1010 1020 1030 1040 1050
FINEIEKEKK NVFMRTFEAI SRNFSEIFAK LSPGGSARLI LENPEDPFSG
1060 1070 1080 1090 1100
GLEIEAKPAG KDVKRIEAMS GGEKALTALA FVFAIQKFKP APFYLFDEID
1110 1120 1130 1140 1150
AHLDDANVKR VADLIKESSK ESQFIVITLR DVMMANADKI IGVSMRDGVS
1160 1170
KVVSLSLEKA MKILEEIRKK QGWEHGN
Length:1,177
Mass (Da):135,014
Last modified:May 31, 2011 - v2
Checksum:iEC12C4C060E5A1CB
GO

Sequence cautioni

The sequence AAL81967 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ543649 Genomic DNA. Translation: CAD66602.1.
AE009950 Genomic DNA. Translation: AAL81967.1. Different initiation.
RefSeqiWP_014835559.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81967; AAL81967; PF1843.
GeneIDi1469722.
KEGGipfu:PF1843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ543649 Genomic DNA. Translation: CAD66602.1.
AE009950 Genomic DNA. Translation: AAL81967.1. Different initiation.
RefSeqiWP_014835559.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEWX-ray2.00X1-182[»]
Y1006-1177[»]
1XEXX-ray2.50A1-182[»]
3KTAX-ray1.63A/C1-182[»]
B/D1006-1177[»]
3NWCX-ray1.70A/B488-667[»]
4I99X-ray2.30A/B1-1172[»]
4RSJX-ray3.50A/B/C/D445-720[»]
ProteinModelPortaliQ8TZY2.
SMRiQ8TZY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-54374N.
IntActiQ8TZY2. 2 interactors.
STRINGi186497.PF1843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81967; AAL81967; PF1843.
GeneIDi1469722.
KEGGipfu:PF1843.

Phylogenomic databases

eggNOGiarCOG00371. Archaea.
COG1196. LUCA.
HOGENOMiHOG000228754.
KOiK03529.

Miscellaneous databases

EvolutionaryTraceiQ8TZY2.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
HAMAPiMF_01894. Smc_prok. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsiTIGR02169. SMC_prok_A. 1 hit.
TIGR02168. SMC_prok_B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC_PYRFU
AccessioniPrimary (citable) accession number: Q8TZY2
Secondary accession number(s): Q877I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.