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Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi136 – 141ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processOne-carbon metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Short name:
AdoMet synthaseUniRule annotation
Alternative name(s):
Methionine adenosyltransferaseUniRule annotation
Gene namesi
Name:matUniRule annotation
Ordered Locus Names:PF1866
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500371 – 401S-adenosylmethionine synthaseAdd BLAST401

Proteomic databases

PRIDEiQ8TZW1

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1866

Structurei

3D structure databases

ProteinModelPortaliQ8TZW1
SMRiQ8TZW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01678 Archaea
COG1812 LUCA
HOGENOMiHOG000229842
KOiK00789
OMAiRPMSMEA
OrthoDBiPOG093Z08AA

Family and domain databases

HAMAPiMF_00136 S_AdoMet_synth2, 1 hit
InterProiView protein in InterPro
IPR027790 AdoMet_synthase_2_family
IPR002795 S-AdoMet_synthetase_arc
PANTHERiPTHR36697 PTHR36697, 1 hit
PfamiView protein in Pfam
PF01941 AdoMet_Synthase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNIVVEEI VRTPVEMQQV ELVERKGIGH PDSIADGIAE AVSRALCREY
60 70 80 90 100
IRRYGVILHH NTDQVEVVGG RAYPRFGGGE VVKPIYILLS GRAVELVDQE
110 120 130 140 150
LFPVHEVAIK AAKNYLKNAI RHLDVENHVI IDSRIGQGSV DLVSVFNKAR
160 170 180 190 200
ENPIPLANDT SFGVGYAPLS ETERLVLETE KLLNSEKFKK EYPAVGEDIK
210 220 230 240 250
VMGLRRGNEI DLTIAAAIVD SEVATPKEYL EVKDKIKEAV EELAKEITSR
260 270 280 290 300
KVNIYVNTAD DPERGIYYIT VTGTSAEAGD DGSVGRGNRV NGLITPNRHM
310 320 330 340 350
SMEAAAGKNP VSHVGKIYNI LAMLIAEDIA KTLPVEEVYV RILSQIGKPI
360 370 380 390 400
DQPLVASIQV IPKPGHSVKE FEKDAYSIAD EWLANITKVQ KMILEDKISV

F
Length:401
Mass (Da):44,281
Last modified:June 1, 2002 - v1
Checksum:i4E764C50A5F25B8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81990.1
RefSeqiWP_011013005.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81990; AAL81990; PF1866
GeneIDi1469745
KEGGipfu:PF1866
PATRICifig|186497.12.peg.1936

Similar proteinsi

Entry informationi

Entry nameiMETK_PYRFU
AccessioniPrimary (citable) accession number: Q8TZW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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