Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi136 – 141ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Short name:
AdoMet synthaseUniRule annotation
Alternative name(s):
Methionine adenosyltransferaseUniRule annotation
Gene namesi
Name:matUniRule annotation
Ordered Locus Names:PF1866
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500371 – 401S-adenosylmethionine synthaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1866.

Structurei

3D structure databases

ProteinModelPortaliQ8TZW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01678. Archaea.
COG1812. LUCA.
HOGENOMiHOG000229842.
KOiK00789.
OMAiHNTDQVE.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2. 1 hit.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TZW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNIVVEEI VRTPVEMQQV ELVERKGIGH PDSIADGIAE AVSRALCREY
60 70 80 90 100
IRRYGVILHH NTDQVEVVGG RAYPRFGGGE VVKPIYILLS GRAVELVDQE
110 120 130 140 150
LFPVHEVAIK AAKNYLKNAI RHLDVENHVI IDSRIGQGSV DLVSVFNKAR
160 170 180 190 200
ENPIPLANDT SFGVGYAPLS ETERLVLETE KLLNSEKFKK EYPAVGEDIK
210 220 230 240 250
VMGLRRGNEI DLTIAAAIVD SEVATPKEYL EVKDKIKEAV EELAKEITSR
260 270 280 290 300
KVNIYVNTAD DPERGIYYIT VTGTSAEAGD DGSVGRGNRV NGLITPNRHM
310 320 330 340 350
SMEAAAGKNP VSHVGKIYNI LAMLIAEDIA KTLPVEEVYV RILSQIGKPI
360 370 380 390 400
DQPLVASIQV IPKPGHSVKE FEKDAYSIAD EWLANITKVQ KMILEDKISV

F
Length:401
Mass (Da):44,281
Last modified:June 1, 2002 - v1
Checksum:i4E764C50A5F25B8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81990.1.
RefSeqiWP_011013005.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81990; AAL81990; PF1866.
GeneIDi1469745.
KEGGipfu:PF1866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81990.1.
RefSeqiWP_011013005.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8TZW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81990; AAL81990; PF1866.
GeneIDi1469745.
KEGGipfu:PF1866.

Phylogenomic databases

eggNOGiarCOG01678. Archaea.
COG1812. LUCA.
HOGENOMiHOG000229842.
KOiK00789.
OMAiHNTDQVE.

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2. 1 hit.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETK_PYRFU
AccessioniPrimary (citable) accession number: Q8TZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.